Hippocampal volume and early life stress in adults with major depressive disorder

2011 ◽  
Author(s):  
S. J. Kim ◽  
J. E. Park ◽  
H. J. Lee ◽  
Y. J. Lee ◽  
S. J. Cho
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Hippocampal Volume ◽  
Major Depressive

Stress and the Brain

2018 ◽  
pp. 434-462
Author(s):  
Deanna M. Barch ◽  
David Pagliaccio
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Life Stress ◽  
Early Life ◽  
Diffusion Imaging ◽  
Early Life Stress ◽  
Resting State Functional Connectivity ◽  
Major Depressive ◽  
Brain Structure And Function ◽  
And Function

This chapter reviews associations between early life stress and brain structure and function as assessed by structural and functional magnetic resonance imaging. Particularly, this chapter focuses on structural associations in children and adults and the regional overlap with neural alterations observed in major depressive disorder, though we also more briefly cover diffusion imaging, task-based imaging, and resting-state functional connectivity. Major depressive disorder is highlighted given that early life stress is a critical risk factor for depression and the neural alterations observed with stress and depression may serve as key mediating factors of this association. A brief methodological overview is provided for each neuroimaging domain as well as a discussion of limitations and future directions for this field.

scholarly journals Impact of Early-Life Stress and Resilience on Patients with Major Depressive Disorder

2012 ◽  
Vol 53 (6) ◽  
pp. 1093 ◽  
Author(s):  
Jeong-Ho Seok ◽  
Kyoung-Uk Lee ◽  
Won Kim ◽  
Seung-Hwan Lee ◽  
Eun-Ho Kang ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Major Depressive

scholarly journals Alterations of the HPA Axis Observed in Patients with Major Depressive Disorder and Their Relation to Early Life Stress: A Systematic Review

2020 ◽  
Vol 79 (6) ◽  
pp. 417-427 ◽  
Author(s):  
Angela Ceruso ◽  
Mayte Martínez-Cengotitabengoa ◽  
Araminta Peters-Corbett ◽  
Maria Jose Diaz-Gutierrez ◽  
Monica Martínez-Cengotitabengoa
Keyword(s):  
Systematic Review ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Hpa Axis ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Major Depressive ◽  
Mediating Role ◽  
Manual Search

<b><i>Background:</i></b> Alterations of the hypothalamic-pituitary-adrenal (HPA) axis are common in patients diagnosed with major depressive disorder (MDD). Nevertheless, these alterations are not found in every patient. There is evidence to indicate a possible mediating role of early life stress (ELS) in the relation between dysfunction of the HPA axis and MDD. We conducted a systematic review to understand if the alterations of the HPA axis commonly found in patients with MDD are due to early life stress or are caused by the disorder itself. <b><i>Methods:</i></b> The review was conducted by following the PRISMA guidelines. Original articles were found in PubMed and via a manual search. Only studies whose design allowed comparison of the HPA functioning in the 4 groups no-MDD/no-ELS, MDD/no-ELS, no-MDD/ELS, and MDD/ELS were included. <b><i>Results:</i></b> Hyperactivity or hypoactivity of the HPA axis was found in 8 articles. A greater number of abnormalities and a higher rate of posttraumatic stress disorder comorbidity were found in the MDD/ELS group. Dysfunction of the HPA axis was also found in the no-MDD/ELS groups. <b><i>Conclusion:</i></b> HPA dysfunction found in MDD seems to be more related to the presence of ELS rather than to the MDD itself. Future studies are needed to clarify the exact mechanisms involved.

scholarly journals Association of Early-Life Stress With Cytomegalovirus Infection in Adults With Major Depressive Disorder

2019 ◽  
Vol 76 (5) ◽  
pp. 545 ◽  
Author(s):  
Bart N. Ford ◽  
Robert H. Yolken ◽  
Robin L. Aupperle ◽  
T. Kent Teague ◽  
Michael R. Irwin ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Life Stress ◽  
Early Life ◽  
Cytomegalovirus Infection ◽  
Early Life Stress ◽  
Major Depressive
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