Treating depressive behaviors with cellular therapy in female rats with brain injury

2010 ◽  
Author(s):  
O.R. Fedotova ◽  
T.V. Avaliani ◽  
I.B. Sokolova
Keyword(s):  
Brain Injury ◽  
Cellular Therapy ◽  
Female Rats

scholarly journals Contrast enhanced magnetic resonance imaging highlights neurovasculature changes following experimental traumatic brain injury in the rat

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
David K. Wright ◽  
Jamie N. Mayo ◽  
Mujun Sun ◽  
Terence J. O’Brien ◽  
Sandy R. Shultz
Keyword(s):  
Magnetic Resonance Imaging ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Magnetic Resonance ◽  
Female Rats ◽  
Resonance Imaging ◽  
Male And Female Rats ◽  
Cerebrovascular Function ◽  
Contrast Enhanced ◽  
Males And Females

AbstractNeurovascular injury has been proposed as a universal pathological hallmark of traumatic brain injury (TBI) with molecular markers of angiogenesis and endothelial function associated with injury severity and morbidity. Sex differences in the neurovasculature response post-TBI may contribute to the differences seen in how males and females respond to injury. Steady-state contrast enhanced magnetic resonance imaging (SSCE-MRI) can be used to non-invasively assess the neurovasculature and may be a useful tool in understanding and predicting outcomes post-TBI. Here we used SSCE-MRI to investigate the neurovasculature of male and female rats at 48 h after an experimental TBI, and how these changes related to neuromotor function at 1-week post-TBI. In addition to TBI induced changes, we found that female rats had greater vessel density, greater cerebral blood volumes and performed better on a neuromotor task than their male counterparts. These results suggest that acute post-TBI cerebrovascular function is worse in males, and that this may contribute to the greater functional deficits observed post-injury. Furthermore, these results highlight the potential of SSCE-MRI to provide insights into the cerebral microvasculature post-TBI. Future studies, incorporating both males and females, are warranted to investigate the evolution of these changes and the underlying mechanisms.

scholarly journals The Effect of Candesartan Alone and Its Combination With Estrogen on Post-traumatic Brain Injury Outcomes in Female Rats

2019 ◽  
Vol 13 ◽  
Author(s):  
Mojdeh Hajmohammadi ◽  
Mohammad Khaksari ◽  
Zahra Soltani ◽  
Nader Shahrokhi ◽  
Hamid Najafipour ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Female Rats ◽  
Post Traumatic ◽  
Injury Outcomes

Effect of sex steroid hormones on brain edema, intracranial pressure, and neurologic outcomes after traumatic brain injury

2010 ◽  
Vol 88 (4) ◽  
pp. 414-421 ◽  
Author(s):  
Nader Shahrokhi ◽  
Mohammad Khaksari ◽  
Zahra Soltani ◽  
Mehdi Mahmoodi ◽  
Nouzar Nakhaee
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Intracranial Pressure ◽  
Steroid Hormones ◽  
Brain Edema ◽  
Sex Steroid Hormones ◽  
Female Rats ◽  
Sex Steroid ◽  
Vehicle Group ◽  
Ovx Rats

Recent studies have reported that estrogen and progesterone have a neuroprotective effect after traumatic brain injury (TBI); however, the mechanism(s) for this effect have not yet been elucidated. The aim of the present study was to investigate the role of sex steroid hormones on changes in brain edema, intracranial pressure (ICP), and cerebral perfusion pressure (CPP) after TBI in ovariectomized (OVX) rats. In this study, 50 female rats were divided into 5 groups: control (intact), sham, and 3 TBI groups consisting of vehicle, estrogen (1 mg/kg), and progesterone (8 mg/kg). TBI was induced by the Marmarou method, and the hormones were injected i.p. 30 min after TBI. ICP was measured in the spinal cord, and CPP was calculated by subtracting the mean arterial pressure (MAP) from ICP. The results revealed that brain water content after TBI was lower (p < 0.001) in the estrogen and progesterone groups than in the vehicle group. After trauma, ICP was significantly higher in TBI rats (p < 0.001). The ICP in the estrogen and progesterone groups decreased at 4 and 24 h after TBI compared with vehicle (p < 0.001 and p < 0.05, respectively). The CPP in the estrogen and progesterone groups increased after 24 h compared with vehicle (p < 0.001). Also after TBI, the neurological score (veterinary coma scale) was significantly higher than vehicle at 1 h (p < 0.01) and 24 h (p < 0.001) in the group treated with estrogen. In conclusion, pharmacological doses of estrogen and progesterone improved ICP, CPP, and neurological scores after TBI in OVX rats, which implies that these hormones play a neuroprotective role in TBI.

High fructose diet-induced obesity worsens post-ischemic brain injury in the hippocampus of female rats

2020 ◽  
pp. 1-15 ◽  
Author(s):  
P. A. Pérez-Corredor ◽  
J. A. Gutiérrez-Vargas ◽  
L. Ciro-Ramírez ◽  
Norman Balcazar ◽  
G. P. Cardona-Gómez
Keyword(s):  
Brain Injury ◽  
Female Rats ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
High Fructose Diet ◽  
Diet Induced Obesity ◽  
High Fructose
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