Evaluation of stress and psychological complications due to consumption of antiepileptic drug in epileptic children

2008 ◽  
Author(s):  
M. Nobahar ◽  
A. A. Vafaei ◽  
A. Samaei
Keyword(s):  
Antiepileptic Drug ◽  
Epileptic Children

Discontinuation of Antiepileptic Drug Treatment After Two Seizure-free Years in Children With Cerebral Palsy

PEDIATRICS ◽  
1996 ◽  
Vol 97 (2) ◽  
pp. 192-197
Author(s):  
Mauricio R. Delgado ◽  
Anthony R. Riela ◽  
Janith Mills ◽  
Alan Pitt ◽  
Richard Browne
Keyword(s):  
Cerebral Palsy ◽  
Mental Retardation ◽  
Antiepileptic Drug ◽  
Spastic Diplegia ◽  
Multiple Factors ◽  
Spastic Hemiparesis ◽  
Children With Cerebral Palsy ◽  
Epileptic Children ◽  
Seizure Relapse ◽  
Antiepileptic Drug Treatment

Objective. The risk of seizure relapse after antiepileptic drug (AED) discontinuation in children has been reported to vary between 6% and 40%. It has been suggested that neurologic deficit and mental retardation are poor prognostic factors for seizure relapse after AED discontinuation. Because epileptic children with cerebral palsy (CP) have neurologic deficits, and many have mental retardation, it is important to know their risk for seizure relapse. Methods. AED treatment was discontinued in 65 children with CP and histories of epilepsy after 2 seizure-free years. All of the patients were followed until they had seizure relapses or for at least 2 years without seizures after AEDs were stopped. Multiple factors were analyzed for possible association with seizure relapse. Results. Twenty-seven patients (41.5%) had seizure relapses. Patients with spastic hemiparesis had the highest relapse rate (61.5%), and those with spastic diplegia had the lowest rate (14.3%). No other factor correlated significantly with the risk of seizure relapse. Conclusions. Discontinuation of AEDs in children with CP can, and should, be practiced when possible after patients have been seizure-free for at least 2 years. AED discontinuation in patients with spastic hemiparesis is significantly more likely to lead to seizure relapse than in patients with other CP types, but no other factor is yet known to increase the chance of relapse.

scholarly journals Bone mineral density in children with long-term antiepileptic therapy

2013 ◽  
Vol 141 (5-6) ◽  
pp. 329-332 ◽  
Author(s):  
Milena Dimic ◽  
Aleksandar Dimic ◽  
Zoran Milosevic ◽  
Jelena Vojinovic
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Drug Therapy ◽  
Antiepileptic Drug ◽  
Bone Mineral ◽  
Control Group ◽  
Mineral Density ◽  
Antiepileptic Therapy ◽  
Epileptic Children ◽  
Antiepileptic Drug Therapy

Introduction. Vitamin D active metabolites deficit that is altered by negative calcium and phosphorus balance is a potential complication during long?term antiepileptic drug therapy. Objective. The aim of this study was to examine lumbar bone mineral density (BMD) in epileptic children receiving antiepileptic drug therapy longer than one year. methods. The examined sample consisted of 34 epileptic children, 18 male and 16 female, aged 6?12 (9.77?2.01) years, treated with carbamazepine, valproate, phenobarbital, lamotrigine or their combination without vitamin D supplementation. The lumbar spine BMD (L1?L4) was estimated by a Lunar densitometer and obtained results were compared with results of 35 matched population of healthy children from the control group. results. Lumbar BMD Z?score was significantly lower in female patients treated with antiepileptic therapy compared with those in the control group (?1.048?1.35 vs. ?0.399?0.518; p=0.03). Bone mineral density Z?score decrease of both gender groups receiving antiepileptic polytherapy was significantly lower compared to the control group (?1.153?0.938 vs. ?0.043?0.815; p=0.007). Therapy duration had no influence on the lumbar BMD level decrease either in boys (rxy=0.33; p=0.174) or in girls (rxy=0.02; p=0.935) treated with antiepileptic therapy. Conclusion. Our results have indicated that antiepileptic drug therapy usage longer than one year can have adverse affects on the lumbar spine BMD (L1?L4) in epileptic children, and that prophylactic vitamin D supplementation is also necessary in these patients.

P.1.b.004 Antiepileptic drug therapy and EEG in epileptic children

2014 ◽  
Vol 24 ◽  
pp. S173-S174
Author(s):  
I. Khachidze ◽  
V.M. Maloletnev ◽  
M.G. Gugushvili
Keyword(s):  
Drug Therapy ◽  
Antiepileptic Drug ◽  
Epileptic Children ◽  
Antiepileptic Drug Therapy

scholarly journals The potential implication of SCN1A and CYP3A5 genetic variants on antiepileptic drug resistance among Egyptian epileptic children

Seizure ◽  
2016 ◽  
Vol 41 ◽  
pp. 75-80 ◽  
Author(s):  
Wafaa Moustafa M. Abo El Fotoh ◽  
Sameh abd Allah Abd el naby ◽  
Mona Salah El-din Habib ◽  
Abeer Ahmed ALrefai ◽  
Zeinab A. Kasemy
Keyword(s):  
Drug Resistance ◽  
Antiepileptic Drug ◽  
Genetic Variants ◽  
Potential Implication ◽  
Epileptic Children

Factors associated with relapse after antiepileptic drug withdrawal in a selected population with partial epilepsy

1999 ◽  
Vol 41 (9) ◽  
pp. 643-645 ◽  
Author(s):  
Alberto Verrotti ◽  
Simonetta Morresi ◽  
Rocco Cutarella ◽  
Guido Morgese ◽  
Francesco Chiarelli
Keyword(s):  
Antiepileptic Drug ◽  
Drug Withdrawal ◽  
Partial Epilepsy ◽  
Factors Associated ◽  
Antiepileptic Drug Withdrawal
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