New analysis of the time reorganization of the ongoing EEG oscillations during the generation of the auditory P300 in schizophrenics

2004 ◽  
Author(s):  
V. Rodionov ◽  
J. Zislin
Keyword(s):  
1994 ◽  
Vol 110 (1) ◽  
pp. 53-59 ◽  
Author(s):  
H BIRDSALL ◽  
L OZLUOGLU ◽  
H LEW ◽  
J TRIAL ◽  
D BROWN ◽  
...  

2009 ◽  
Vol 35 (5) ◽  
pp. 523-530 ◽  
Author(s):  
L. B. Oknina ◽  
O. A. Kuznetsova ◽  
E. V. Enikolopova

2019 ◽  
Vol 130 (1) ◽  
pp. 46-54 ◽  
Author(s):  
Silvia Kyungjin Lho ◽  
Minah Kim ◽  
Tak Hyung Lee ◽  
Yoo Bin Kwak ◽  
Jun Soo Kwon

CNS Spectrums ◽  
2017 ◽  
Vol 23 (4) ◽  
pp. 264-270 ◽  
Author(s):  
Ching-Lin Chu ◽  
I Hui Lee ◽  
Mei Hung Chi ◽  
Kao Chin Chen ◽  
Po See Chen ◽  
...  

ObjectivePrevious studies have indicated that there is dopamine transporter (DAT) dysregulation and P300 abnormality in adults with attention-deficit hyperactivity disorder (ADHD); however, the correlations among the three have not been fully explored.MethodsA total of 11 adults (9 males and 2 females) with ADHD and 11 age-, sex-, and education-level-matched controls were recruited. We explored differences in DAT availability using single-photon emission computed tomography and P300 wave of event-related potentials between the two groups. The correlation between DAT availability and P300 performance was also examined.ResultsDAT availability in the basal ganglia, caudate nucleus, and putamen was significantly lower in the ADHD group. Adults with ADHD had lower auditory P300 amplitudes at the Pz and Cz sites, as well as longer Fz latency than controls. DAT availability was negatively correlated to P300 latency at Pz and Fz.ConclusionsAdults with ADHD had both abnormal DAT availability and P300 amplitude, suggesting that ADHD is linked to dysfunction of the central dopaminergic system and poor cognitive processes related to response selection and execution.


2018 ◽  
Vol 51 (4) ◽  
pp. 252-258
Author(s):  
Minah Kim ◽  
Tak Hyung Lee ◽  
Wu Jeong Hwang ◽  
Tae Young Lee ◽  
Jun Soo Kwon

Background. The reduced amplitude, prolonged latency, and increased intertrial variability of auditory P300 have been consistently reported in relation to the symptomatic severity of schizophrenia. This study investigated whether auditory P300 event-related potentials can be used as an objective indicator of symptomatic improvement by transcranial direct current stimulation (tDCS) in patients with schizophrenia. Methods. Ten patients with schizophrenia received 20 minutes of 2-mA tDCS twice a day for 5 consecutive weekdays. The anode was placed over the left dorsolateral prefrontal cortex, and the cathode was placed over the left temporo-parietal cortex. The Positive and Negative Syndrome Scale (PANSS) and the auditory P300 were measured for each participant at baseline and after the completion of the tDCS applications. Results. The participants showed significant improvement in the positive and negative symptoms as indexed by change in the PANSS scores by the tDCS. The P300 amplitude, latency, and intertrial variability did not statistically significantly differ after the tDCS application. However, a significant association was observed between the reduced P300 intertrial variability and improvement in the positive symptoms by tDCS. In addition, the changes in both the P300 latency and intertrial variability were significantly correlated with reduced negative symptoms after the tDCS application. Conclusions. Although this pilot study is limited by the small sample size and lack of a sham control, the results suggest that auditory P300 may be a putative marker reflecting the effect of tDCS on the positive and negative symptoms of schizophrenia.


2007 ◽  
Vol 38 (3) ◽  
pp. 168-171 ◽  
Author(s):  
Wuttichai V. Chayasirisobhon ◽  
Sirichai Chayasirisobhon ◽  
Sue Nwe Tin ◽  
Ngoc Leu ◽  
Keo Tehrani ◽  
...  

We studied scalp-recorded auditory event-related potentials (ERPs) of 30 untreated patients with new-onset temporal lobe epilepsy and 30 age-and sex-matched normal controls. This study was designed to eliminate the effects of intractability of seizures and chronic use of antiepileptic drugs on P300 auditory ERPs. There were no statistically significant differences in both latency and amplitude of P300 between the two groups. Similar methods were also used to analyze component latencies and amplitudes of ERPs of 9 patients who had hippocampal sclerosis with comparison to control subjects. There were no statistically significant differences between these two groups as well. Our study evidently does not support temporal lobe sources of P300 scalp-recorded auditory ERPs. We also conclude that the scalp-recorded auditory ERPs procedure is not a useful tool to evaluate temporal lobe epilepsy.


2013 ◽  
Author(s):  
Zacharias Vamvakousis ◽  
Rafael Ramirez

P300-based brain-computer interfaces (BCIs) are especially useful for people with illnesses, which prevent them from communicating in a normal way (e.g. brain or spinal cord injury). However, most of the existing P300-based BCI systems use visual stimulation which may not be suitable for patients with sight deterioration (e.g. patients suffering from amyotrophic lateral sclerosis). Moreover, P300-based BCI systems rely on expensive equipment, which greatly limits their use outside the clinical environment. Therefore, we propose a multi-class BCI system based solely on auditory stimuli, which makes use of low-cost EEG technology. We explored different combinations of timbre, pitch and spatial auditory stimuli (TimPiSp: timbre-pitch-spatial, TimSp: timbre-spatial, and Timb: timbre-only) and three inter-stimulus intervals (150ms, 175ms and 300ms), and evaluated our system by conducting an oddball task on 7 healthy subjects. This is the first study in which these 3 auditory cues are compared. After averaging several repetitions in the 175ms inter-stimulus interval, we obtained average selection accuracies of 97.14%, 91.43%, and 88.57% for modalities TimPiSp, TimSp, and Timb, respectively. Best subject’s accuracy was 100% in all modalities and inter-stimulus intervals. Average information transfer rate for the 150ms inter-stimulus interval in the TimPiSp modality was 14.85 bits/min. Best subject’s information transfer rate was 39.96 bits/min for 175ms Timbre condition. Based on the TimPiSp modality, an auditory P300 speller was implemented and evaluated by asking users to type a 12-characters-long phrase. Six out of 7 users completed the task. The average spelling speed was 0.56 chars/min and best subject’s performance was 0.84 chars/min. The obtained results show that the proposed auditory BCI is successful with healthy subjects and may constitute the basis for future implementations of more practical and affordable auditory P300-based BCI systems.


Sign in / Sign up

Export Citation Format

Share Document