Cardiovascular Toxicity of Cocaine

1988 ◽  
Author(s):  
R. Douglas Wilkerson ◽  
Keyword(s):  
Cardiovascular Toxicity

scholarly journals Exploring the Potential Role of the Gut Microbiome in Chemotherapy-Induced Neurocognitive Disorders and Cardiovascular Toxicity

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 782
Author(s):  
Sona Ciernikova ◽  
Michal Mego ◽  
Michal Chovanec
Keyword(s):  
Cardiovascular Diseases ◽  
Cancer Survivors ◽  
Cancer Patients ◽  
Gut Microbiome ◽  
Late Effects ◽  
Fecal Microbiota Transplantation ◽  
Experimental Models ◽  
Neurocognitive Disorders ◽  
Cardiovascular Toxicity

Chemotherapy, targeting not only malignant but also healthy cells, causes many undesirable side effects in cancer patients. Due to this fact, long-term cancer survivors often suffer from late effects, including cognitive impairment and cardiovascular toxicity. Chemotherapy damages the intestinal mucosa and heavily disrupts the gut ecosystem, leading to gastrointestinal toxicity. Animal models and clinical studies have revealed the associations between intestinal dysbiosis and depression, anxiety, pain, impaired cognitive functions, and cardiovascular diseases. Recently, a possible link between chemotherapy-induced gut microbiota disruption and late effects in cancer survivors has been proposed. In this review, we summarize the current understanding of preclinical and clinical findings regarding the emerging role of the microbiome and the microbiota–gut–brain axis in chemotherapy-related late effects affecting the central nervous system (CNS) and heart functions. Importantly, we provide an overview of clinical trials evaluating the relationship between the gut microbiome and cancer survivorship. Moreover, the beneficial effects of probiotics in experimental models and non-cancer patients with neurocognitive disorders and cardiovascular diseases as well as several studies on microbiota modulations via probiotics or fecal microbiota transplantation in cancer patients are discussed.

scholarly journals Diagnosis, Prevention, Treatment and Surveillance of Anthracycline-Induced Cardiovascular Toxicity in Pediatric Cancer Survivors

Hearts ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 45-60
Author(s):  
Valerie Curren ◽  
Niti Dham ◽  
Christopher Spurney
Keyword(s):  
Pediatric Cancer ◽  
Systolic Function ◽  
Treatment Strategies ◽  
Significant Risk ◽  
Imaging Biomarkers ◽  
Cancer Therapies ◽  
Cardiovascular Toxicity ◽  
Treatment Protocols ◽  
Mechanisms Of Toxicity ◽  
Pediatric Cancer Survivors

Advances in pediatric cancer therapies have dramatically improved the likelihood of survival. As survivors are aging, however, we are now understanding that treatment carries a significant risk of cardiovascular toxicity, which can develop immediately, or even many years after completing therapy. Anthracycline derivates are some of the most commonly used agents in pediatric oncology treatment protocols, which have a dose-dependent correlation with the development of cardiac toxicity. As we learn more about the mechanisms of toxicity, we are developing prevention strategies, including improvements in surveillance, to improve early diagnosis of heart disease. Current survivorship surveillance protocols often include screening echocardiograms to evaluate systolic function by measuring the ejection fraction or fractional shortening. However, these measurements alone are not enough to capture early myocardial changes. The use of additional imaging biomarkers, serum biomarkers, electrocardiograms, as well as cholesterol and blood pressure screening, are key to the early detection of cardiomyopathy and cardiovascular disease. Medical treatment strategies are the same as those used for heart failure from other causes, but earlier recognition and implementation can lead to improved long term outcomes.

Cardiovascular Toxicity Associated With Cancer Treatment

2008 ◽  
Vol 12 (4) ◽  
pp. 627-638 ◽  
Author(s):  
Pamela Hallquist Viale ◽  
Deanna Sanchez Yamamoto
Keyword(s):  
Cancer Treatment ◽  
Cardiovascular Toxicity

Nano zerovalent iron particles induce pulmonary and cardiovascular toxicity in an in vitro human co-culture model

2016 ◽  
Vol 10 (7) ◽  
pp. 881-890 ◽  
Author(s):  
Zhelin Sun ◽  
Lingyan Yang ◽  
Ku-Fan Chen ◽  
Guan-Wen Chen ◽  
Yen-Ping Peng ◽  
...  
Keyword(s):  
Zerovalent Iron ◽  
Cardiovascular Toxicity ◽  
Iron Particles ◽  
Culture Model ◽  
Nano Zerovalent Iron

scholarly journals Acute life-threatening cardiovascular toxicity with umbilical cord blood infusion: The role of dextran

2010 ◽  
Vol 85 (9) ◽  
pp. 722-724 ◽  
Author(s):  
Robert W. Ma ◽  
John M. Kwan ◽  
David D. Ma ◽  
Keith C. Fay
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Cardiovascular Toxicity ◽  
Life Threatening
Sign in / Sign up

Export Citation Format

Share Document