Plasma l-tryptophan levels, subjective sleepiness, and daytime sleep.

1980 ◽  
Author(s):  
Cheryl L. Spinweber
Keyword(s):  
Daytime Sleep ◽  
Subjective Sleepiness

Daytime sleep after glucose intake in patients with narcolepsy

2007 ◽  
Vol 40 (05) ◽  
Author(s):  
R Wehrle ◽  
P Beitinger ◽  
M Dalal ◽  
A Schuld ◽  
TC Wetter ◽  
...  
Keyword(s):  
Daytime Sleep ◽  
Glucose Intake

341 Acute effects of seltorexant, a selective orexin-2 antagonist (JNJ- 42847922), on driving after bedtime administration

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A136-A136
Author(s):  
S Brooks ◽  
R G J A Zuiker ◽  
G E Jacobs ◽  
I Kezic ◽  
A Savitz ◽  
...  
Keyword(s):  
Postural Stability ◽  
Driving Simulator ◽  
Motor Vehicle ◽  
Subjective Effects ◽  
Driving Ability ◽  
Post Dose ◽  
Double Blind ◽  
Increased Risk ◽  
Subjective Sleepiness ◽  
The Difference

Abstract Introduction Seltorexant (JNJ-42847922), a potent and selective antagonist of the human orexin-2 receptor, is being developed for the treatment of major depressive disorder. Seltorexant also has sleep-promoting properties. Investigating the effects of sleep-promoting medications on driving is important because some of these agents (e.g. GABAA receptor agonists) may be associated with increased risk of motor vehicle accidents. We evaluated the effect of seltorexant on driving after forced awakening at night, using a validated driving simulator. Methods This double-blind, placebo and active-controlled, randomized, 3-way cross-over study was conducted in 18 male and 18 female healthy subjects. All subjects received seltorexant 40 mg, zolpidem 10 mg, or placebo 15 minutes before bedtime. Eighteen subjects were awakened at 2- and 6-hours post-dose, and the other 18 at 4- and 8-hours post-dose. At those timepoints, pharmacokinetics, objective (standard deviation of the lateral position [SDLP]) and subjective effects (using Perceived Driving Quality and Effort Scales) on driving ability, postural stability and subjective sleepiness were assessed. Results For seltorexant, the SDLP difference from placebo (95% confidence interval) at 2-, 4-, 6- and 8-hours post-dose was 3.9 cm (1.26, 6.60), 0.9 cm (-1.08, 2.92), 1.1 cm (-0.42, 2.63), and 0.6 cm (-2.75, 1.55), respectively vs. 9.6 cm (6.97, 12.38), 6.6 cm (3.53, 9.60), 4.7 cm (1.46, 7.85), and 1.3cm (-1.16, 3.80), respectively for zolpidem. The difference from placebo was significant at 2-hours after taking seltorexant, while the difference from placebo was significant at 2, 4 and 6-hours after zolpidem. Subjective driving quality was decreased for both drugs at all time points and driving effort was increased up to 4-hours post-dose for both medications. Subjective sleepiness showed a significant increase compared to placebo 2- and 4-hours after administration of either drug. Postural stability was decreased up to 2-hours after administration of seltorexant, and up to 4-hours after administration of zolpidem. Conclusion Compared to zolpidem, objective effects on driving performance were more transient after seltorexant administration and largely normalized by 4–6 hours post-dose. Support (if any) This work was sponsored by Janssen R&D.

scholarly journals Thermal Comfort and Sleep Quality of Indonesian Students Living in Japan during Summer and Winter

Buildings ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 326
Author(s):  
Wiwik Budiawan ◽  
Kazuyo Tsuzuki
Keyword(s):  
Sleep Quality ◽  
Thermal Comfort ◽  
Thermal Sensation ◽  
Thermal Conditions ◽  
Physical Conditions ◽  
Subjective Sleepiness ◽  
Adaptive Action ◽  
Quality Sleep ◽  
Sleep Parameters

Thermal comfort is crucial in satisfaction and maintaining quality sleep for occupants. In this study, we investigated the comfort temperature in the bedroom at night and sleep quality for Indonesian students during summer and winter. Eighteen male Indonesian students aged 29 ± 4 years participated in this study. The participants had stayed in Japan for about six months. We evaluated the sleep parameters using actigraphy performed during summer and winter. All participants completed the survey regarding thermal sensation, physical conditions, and subjective sleepiness before sleep. The temperature and relative humidity of participants’ bedrooms were also measured. We found that the duration on the bed during winter was significantly longer than that during summer. However, sleeping efficiency during winter was significantly worse than that during summer. The bedroom temperature of the participants was in the range of comfort temperature in Indonesia. With the average bedroom air temperature of 22.2 °C, most of the participants still preferred “warm” and felt “slightly comfortable” during winter. The average comfort temperature each season calculated using the Griffiths method was 28.1 °C during summer and 23.5 °C during winter. In conclusion, differences in adaptive action affect bedroom thermal conditions. Furthermore, habits encourage the sleep performance of Indonesian students.

scholarly journals Subjective and Objective Appraisal of Activity in Adults with Obstructive Sleep Apnea

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Eileen R. Chasens ◽  
Susan M. Sereika ◽  
Martin P. Houze ◽  
Patrick J. Strollo
Keyword(s):  
Physical Activity ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Epworth Sleepiness Scale ◽  
Functional Outcomes ◽  
Apnea Hypopnea Index ◽  
Sleep Study ◽  
Obstructive Sleep ◽  
Subjective Sleepiness ◽  
Aging Adults

Objective.This study examined the association between obstructive sleep apnea (OSA), daytime sleepiness, functional activity, and objective physical activity.Setting.Subjects (N=37) being evaluated for OSA were recruited from a sleep clinic.Participants. The sample was balanced by gender (53% male), middle-aged, primarily White, and overweight or obese with a mean BMI of 33.98 (SD=7.35;median BMI=32.30). Over 40% reported subjective sleepiness (Epworth Sleepiness Scale (ESS) ≥10) and had OSA (78% with apnea + hypopnea index (AHI) ≥5/hr).Measurements.Evaluation included questionnaires to evaluate subjective sleepiness (Epworth Sleepiness Scale (ESS)) and functional outcomes (Functional Outcomes of Sleep Questionnaire (FOSQ)), an activity monitor, and an overnight sleep study to determine OSA severity.Results.Increased subjective sleepiness was significantly associated with lower scores on the FOSQ but not with average number of steps walked per day. A multiple regression analysis showed that higher AHI values were significantly associated with lower average number of steps walked per day after controlling patient's age, sex, and ESS.Conclusion.Subjective sleepiness was associated with perceived difficulty in activity but not with objectively measured activity. However, OSA severity was associated with decreased objective physical activity in aging adults.

Electroencephalogram and cardiovascular responses to noise during daytime sleep in shiftworkers

1993 ◽  
Vol 66 (1) ◽  
pp. 76-84 ◽  
Author(s):  
Alain Nicolas ◽  
V�ronique Bach ◽  
Patricia Tassi ◽  
G�rard Dewasmes ◽  
Jean Ehrhart ◽  
...  
Keyword(s):  
Cardiovascular Responses ◽  
Daytime Sleep

Daytime sleep latency in medication‐matched parkinsonian patients with and without sudden onset of sleep

2005 ◽  
Vol 20 (12) ◽  
pp. 1620-1622 ◽  
Author(s):  
J. Carsten Möller ◽  
Mira Rethfeldt ◽  
Yvonne Körner ◽  
Karin Stiasny‐Kolster ◽  
Werner Cassel ◽  
...  
Keyword(s):  
Sleep Latency ◽  
Sudden Onset ◽  
Daytime Sleep

Influence of nocturnal and daytime sleep on initial orthostatic hypotension

2014 ◽  
Vol 115 (2) ◽  
pp. 269-276 ◽  
Author(s):  
N. C. S. Lewis ◽  
H. Jones ◽  
P. N. Ainslie ◽  
A. Thompson ◽  
K. Marrin ◽  
...  
Keyword(s):  
Orthostatic Hypotension ◽  
Daytime Sleep ◽  
Initial Orthostatic Hypotension

scholarly journals Yawning and subjective sleepiness in the elderly

2008 ◽  
Vol 17 (3) ◽  
pp. 303-308 ◽  
Author(s):  
IOLE ZILLI ◽  
FIORENZA GIGANTI ◽  
VALERIA UGA
Keyword(s):  
The Elderly ◽  
Subjective Sleepiness
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