Sensory mechanism modeling.

1979 ◽  
Author(s):  
Joshua Borah ◽  
Laurence R. Young ◽  
Renwick E. Curry
Keyword(s):  
Mechanism Modeling ◽  
Sensory Mechanism

Sensory Mechanism Modeling

1977 ◽  
Author(s):  
Joshua Borah ◽  
Laurence R. Young ◽  
Renwick E. Curry
Keyword(s):  
Mechanism Modeling ◽  
Sensory Mechanism

scholarly journals Substance P-Immunoreactive Neurons of the Bovine Forestomach Mucosa: Their Presumptive Role in a Sensory Mechanism.

1993 ◽  
Vol 56 (4) ◽  
pp. 399-410 ◽  
Author(s):  
Nobuo KITAMURA ◽  
Junzo YAMADA ◽  
Yoshio YAMAMOTO ◽  
Tadayuki YAMASHITA
Keyword(s):  
Substance P ◽  
Sensory Mechanism

Impact of θ-burst stimulation on memory mechanism: modeling study

2016 ◽  
Vol 37 (3) ◽  
pp. 395-402 ◽  
Author(s):  
Yating Zhu ◽  
Rubin Wang ◽  
Yihong Wang
Keyword(s):  
Burst Stimulation ◽  
Memory Mechanism ◽  
Mechanism Modeling ◽  
Modeling Study

Reconfiguration and Unified Kinematics Analysis of a Metamorphic Parallel Mechanism With Bifurcated Motion

2012 ◽  
Author(s):  
Dongming Gan ◽  
Jian S. Dai ◽  
Lakmal D. Seneviratne
Keyword(s):  
Parallel Mechanism ◽  
Geometric Condition ◽  
Translation Vector ◽  
Kinematics Analysis ◽  
Constraint Equations ◽  
Mechanism Modeling ◽  
The Difference ◽  
Two Phases ◽  
Set Up ◽  
Joint Center

This paper introduced a new metamorphic parallel mechanism consisting of four reconfigurable rTPS limbs. Based on the reconfigurability of the reconfigurable Hooke (rT) joint, the rTPS limb has two phases while in one phase the limb has no constraint to the platform, in the other it constrains the spherical joint center to lie on a plane. This results in the mechanism to have ability of reconfiguration between different topologies with variable mobility. Geometric constraint equations of the platform rotation matrix and translation vector are set up based on the point-plane constraint, which reveals the bifurcated motion property in the topology with mobility 2 and the geometric condition with mobility change in altering to other mechanism topologies. Following this, a unified kinematics limb modeling is proposed considering the difference between the two phases of the reconfigurable rTPS limb. This is further applied for the mechanism modeling and both the inverse and forward kinematics is analytically solved by combining phases of the four limbs covering all the mechanism topologies.

Age-related changes in afferent responses in sensory neurons to mechanical stimulation of osteoblasts in coculture system

2012 ◽  
Vol 302 (5) ◽  
pp. C757-C765 ◽  
Author(s):  
Keiji Asada ◽  
Koji Obata ◽  
Kazuhide Horiguchi ◽  
Miyako Takaki
Keyword(s):  
Receptor Antagonist ◽  
Bone Tissue ◽  
Sensory Neurons ◽  
Satellite Cells ◽  
Mechanical Stimulation ◽  
P2x Receptor ◽  
Bone Homeostasis ◽  
Drg Neurons ◽  
Coculture System ◽  
Sensory Mechanism

Bone homeostasis is regulated by mechanical stimulation (MS). The sensory mechanism of bone tissue for MS remains unknown in the maintenance of bone homeostasis. We aimed to investigate the sensory mechanism from osteoblasts to sensory neurons in a coculture system by MS of osteoblasts. Primary sensory neurons isolated from dorsal root ganglia (DRG) of neonatal, juvenile, and adult mice and osteoblasts isolated from calvaria of neonatal mice were cocultured for 24 h. The responses in DRG neurons elicited by MS of osteoblasts with a glass micropipette were detected by increases in intracellular Ca2+ concentration ([Ca2+]i) with fluo 3-AM. In all developmental stages mice, [Ca2+]i-increasing responses in osteoblasts were promptly elicited by MS. After a short delay, [Ca2+]i-increasing responses were observed in neurites of DRG neurons. The osteoblastic response to second MS was largely attenuated by a stretch-activated Ca2+ channel blocker, gadolinium. The increases of [Ca2+]i in DRG neurons were abolished by a P2 receptor antagonist; suramin, a P2X receptor antagonist, pyridoxal-phosphate-6-azophenyl-2′,4′-disulfonate; and an ATP-hydrolyzing enzyme, apyrase. Satellite cells were found around DRG neurons in cocultured cells of only neonatal and juvenile mice. After satellite cells were removed, excessive abnormal responses to MS of osteoblasts were observed in neonatal neurites with unchanged osteoblast responses. The present study indicated that MS of bone tissue elicited afferent P2X receptor-mediated purinergic transmission to sensory neurons in all stages mice. This transmission is modulated by satellite cells, which may have protective actions on sensory neurons.

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