Science: Neurobehavioral testing overlooked

1989 ◽  
Author(s):  
Tina Adler ◽  
Keyword(s):  
Neurobehavioral Testing

scholarly journals Neurobehavioral Testing in Prion Disease Studies

10.5772/67520 ◽  
2017 ◽  
Author(s):  
Davis M. Seelig ◽  
Michael A. Benneyworth ◽  
Damani N. Bryant
Keyword(s):  
Prion Disease ◽  
Neurobehavioral Testing

scholarly journals Administration of haloperidol and risperidone after neurobehavioral testing hinders the recovery of traumatic brain injury-induced deficits

Life Sciences ◽  
2008 ◽  
Vol 83 (17-18) ◽  
pp. 602-607 ◽  
Author(s):  
Ann N. Hoffman ◽  
Jeffrey P. Cheng ◽  
Ross D. Zafonte ◽  
Anthony E. Kline
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Neurobehavioral Testing

Selective approaches to basic neurobehavioral testing of children in environmental health studies

1996 ◽  
Vol 18 (4) ◽  
pp. 429-434 ◽  
Author(s):  
Robert W. Amler ◽  
Michael Gibertini ◽  
Jeffrey A. Lybarger ◽  
Alvin Hall ◽  
Kirsten Kakolewski ◽  
...  
Keyword(s):  
Environmental Health ◽  
Neurobehavioral Testing ◽  
Health Studies

scholarly journals Earlier preterm birth is associated with a worse neurocognitive outcome in a rabbit model

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0246008
Author(s):  
Johannes van der Merwe ◽  
Lennart van der Veeken ◽  
Analisa Inversetti ◽  
Angela Galgano ◽  
Jaan Toelen ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Rabbit Model ◽  
Late Preterm ◽  
Short Term ◽  
Policy Makers ◽  
Mortality And Morbidity ◽  
Short Term Mortality ◽  
Neurobehavioral Testing ◽  
Postconceptional Age ◽  
Cross Fostering

Background Preterm birth (PTB) and particularly late preterm PTB has become a research focus for obstetricians, perinatologists, neonatologists, pediatricians and policy makers alike. Translational models are useful tools to expedite and guide clinical but presently no model exists that contextualizes the late PTB scenario. Herein we aimed to develop a rabbit model that echo’s the clinical neurocognitive phenotypes of early and late PTB. Methods Time mated rabbit does underwent caesarean delivery at a postconceptional age (PCA) of either 28 (n = 6), 29 (n = 5), 30 (n = 4) or 31 (n = 4) days, term = 31 d. Newborn rabbits were mixed and randomly allocated to be raised by cross fostering and underwent short term neurobehavioral testing on corrected post-natal day 1. Open field (OFT), spontaneous alteration (TMT) and novel object recognition (NORT) tests were subsequently performed at 4 and 8 weeks of age. Results PTB was associated with a significant gradient of short-term mortality and morbidity inversely related to the PCA. On postnatal day 1 PTB was associated with a significant sensory deficit in all groups but a clear motor insult was only noted in the PCA 29d and PCA 28d groups. Furthermore, PCA 29d and PCA 28d rabbits had a persistent neurobehavioral deficit with less exploration and hyperanxious state in the OFT, less alternation in TMT and lower discriminatory index in the NORT. While PCA 30d rabbits had some anxiety behavior and lower spontaneous alteration at 4 weeks, however at 8 weeks only mild anxiety driven behavior was observed in some of these rabbits. Conclusions In this rabbit model, delivery at PCA 29d and PCA 28d mimics the clinical phenotype of early PTB while delivery at PCA 30d resembles that of late PTB. This could serve as a model to investigate perinatal insults during the early and late preterm period.

scholarly journals Neurobehavioral testing in subarachnoid hemorrhage: A review of methods and current findings in rodents

2016 ◽  
Vol 37 (11) ◽  
pp. 3461-3474 ◽  
Author(s):  
Nefize Turan ◽  
Brandon A Miller ◽  
Robert A Heider ◽  
Maheen Nadeem ◽  
Iqbal Sayeed ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Comprehensive Evaluation ◽  
Neurological Diseases ◽  
Preclinical Study ◽  
Cerebrovascular Diseases ◽  
Controlled Clinical Trials ◽  
Novel Therapy ◽  
Neurobehavioral Testing ◽  
Experimental Subarachnoid Hemorrhage ◽  
Double Blinded

The most important aspect of a preclinical study seeking to develop a novel therapy for neurological diseases is whether the therapy produces any clinically relevant functional recovery. For this purpose, neurobehavioral tests are commonly used to evaluate the neuroprotective efficacy of treatments in a wide array of cerebrovascular diseases and neurotrauma. Their use, however, has been limited in experimental subarachnoid hemorrhage studies. After several randomized, double-blinded, controlled clinical trials repeatedly failed to produce a benefit in functional outcome despite some improvement in angiographic vasospasm, more rigorous methods of neurobehavioral testing became critical to provide a more comprehensive evaluation of the functional efficacy of proposed treatments. While several subarachnoid hemorrhage studies have incorporated an array of neurobehavioral assays, a standardized methodology has not been agreed upon. Here, we review neurobehavioral tests for rodents and their potential application to subarachnoid hemorrhage studies. Developing a standardized neurobehavioral testing regimen in rodent studies of subarachnoid hemorrhage would allow for better comparison of results between laboratories and a better prediction of what interventions would produce functional benefits in humans.

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