Study Suggests Lack of Knowledge About Heart Disease Puts Older Women at Risk: Women Underestimate Heart Disease Risk/Overestimate Breast Cancer Risk

1999 ◽  
Author(s):  
Keyword(s):  
Breast Cancer ◽  
At Risk ◽  
Heart Disease ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Older Women ◽  
Disease Risk ◽  
Heart Disease Risk ◽  
Lack Of Knowledge

scholarly journals Analysis of Italian BRCA1/2 Pathogenic Variants Identifies a Private Spectrum in the Population from the Bergamo Province in Northern Italy

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 532
Author(s):  
Gisella Figlioli ◽  
Arcangela De Nicolo ◽  
Irene Catucci ◽  
Siranoush Manoukian ◽  
Bernard Peissel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Disease Risk ◽  
Northern Italy ◽  
Genetic Isolate ◽  
National Population ◽  
Pathogenic Variants ◽  
High Breast Cancer Risk

Germline pathogenic variants (PVs) in the BRCA1 or BRCA2 genes cause high breast cancer risk. Recurrent or founder PVs have been described worldwide including some in the Bergamo province in Northern Italy. The aim of this study was to compare the BRCA1/2 PV spectra of the Bergamo and of the general Italian populations. We retrospectively identified at five Italian centers 1019 BRCA1/2 PVs carrier individuals affected with breast cancer and representative of the heterogeneous national population. Each individual was assigned to the Bergamo or non-Bergamo cohort based on self-reported birthplace. Our data indicate that the Bergamo BRCA1/2 PV spectrum shows less heterogeneity with fewer different variants and an average higher frequency compared to that of the rest of Italy. Consistently, four PVs explained about 60% of all carriers. The majority of the Bergamo PVs originated locally with only two PVs clearly imported. The Bergamo BRCA1/2 PV spectrum appears to be private. Hence, the Bergamo population would be ideal to study the disease risk associated with local PVs in breast cancer and other disease-causing genes. Finally, our data suggest that the Bergamo population is a genetic isolate and further analyses are warranted to prove this notion.

scholarly journals Methylation-Based Biological Age and Breast Cancer Risk

2019 ◽  
Vol 111 (10) ◽  
pp. 1051-1058 ◽  
Author(s):  
Jacob K Kresovich ◽  
Zongli Xu ◽  
Katie M O’Brien ◽  
Clarice R Weinberg ◽  
Dale P Sandler ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cox Regression ◽  
Disease Risk ◽  
Statistical Tests ◽  
Biological Age ◽  
Cancer Case ◽  
Increased Risk

Abstract Background Age is one of the strongest predictors of cancer, chronic disease, and mortality, but biological responses to aging differ among people. Epigenetic DNA modifications have been used to estimate “biological age,” which may be a useful predictor of disease risk. We tested this hypothesis for breast cancer. Methods Using a case-cohort approach, we measured baseline blood DNA methylation of 2764 women enrolled in the Sister Study, 1566 of whom subsequently developed breast cancer after an average of 6 years. Using three previously established methylation-based “clocks” (Hannum, Horvath, and Levine), we defined biological age acceleration for each woman by comparing her estimated biological age with her chronological age. Hazard ratios and 95% confidence intervals for breast cancer risk were estimated using Cox regression models. All statistical tests were two-sided. Results Each of the three clocks showed that biological age acceleration was statistically significantly associated with increased risk of developing breast cancer (5-year age acceleration, Hannum’s clock: hazard ratio [HR] = 1.10, 95% confidence interval [CI] = 1.00 to 1.21, P = .04; Horvath’s clock: HR = 1.08, 95% CI = 1.00 to 1.17, P = .04; Levine’s clock: HR = 1.15, 95% CI = 1.07 to 1.23, P < .001). For Levine’s clock, each 5-year acceleration in biological age corresponded with a 15% increase in breast cancer risk. Although biological age may accelerate with menopausal transition, age acceleration in premenopausal women independently predicted breast cancer. Case-only analysis suggested that, among women who develop breast cancer, increased age acceleration is associated with invasive cancer (odds ratio for invasive = 1.09, 95% CI = 0.98 to 1.22, P = .10). Conclusions DNA methylation-based measures of biological age may be important predictors of breast cancer risk.

Breast Cancer Risk Factors in Younger and Older Women

2009 ◽  
Vol 16 (1) ◽  
pp. 96-99 ◽  
Author(s):  
Jennifer Chun ◽  
Ben Pocock ◽  
Kathie-Ann Joseph ◽  
Mahmoud El-Tamer ◽  
Laura Klein ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Older Women ◽  
Cancer Risk Factors ◽  
Breast Cancer Risk Factors

It Won't Happen to Me: Lower Perception of Heart Disease Risk among Women with Family Histories of Breast Cancer

2000 ◽  
Vol 31 (6) ◽  
pp. 714-721 ◽  
Author(s):  
Joel Erblich ◽  
Dana H. Bovbjerg ◽  
Christina Norman ◽  
Heiddis B. Valdimarsdottir ◽  
Guy H. Montgomery
Keyword(s):  
Breast Cancer ◽  
Heart Disease ◽  
Disease Risk ◽  
Family Histories ◽  
Heart Disease Risk
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