Featured Clinical Trial: Combination Therapy for Head and Neck Cancer

2004 ◽  
Author(s):  
Keyword(s):  
Clinical Trial ◽  
Head And Neck Cancer ◽  
Combination Therapy ◽  
Head And Neck ◽  
Neck Cancer

scholarly journals Arrabidaea chicafor oral mucositis in patients with head and neck cancer: a protocol of a randomised clinical trial

BMJ Open ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. e019505
Author(s):  
Núbia de Cassia Almeida Queiroz ◽  
Michelle Pedroza Jorge ◽  
Ilza Maria de Oliveira Sousa ◽  
Carmen Silvia Passos Lima ◽  
Maria Christina de Miranda Matias ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Oral Mucositis ◽  
Study Groups ◽  
Randomised Clinical Trial ◽  
Ventral Surface ◽  
Low Level Laser Therapy ◽  
Arrabidaea Chica

IntroductionOral mucositis is an iatrogenic condition of erythematous inflammatory changes which tends to occur on buccal and labial surfaces, the ventral surface of the tongue, the floor of the mouth and the soft palate of patients receiving chemotherapy. This protocol of ongoing randomised parallel group clinical trial aims to access the therapeutic effect of an herbal gel containing 2.5%Arrabidaea chicaVerlot standardised extract on oral mucositis in patients with head and neck cancer compared with low-level laser therapy.Methods and analysisPatients with head and neck cancer held at Clinics Hospital of University of Campinas, Sao Paulo, who develop early signs/symptoms of oral mucositis are eligible. Baseline characteristics of participants include oral mucositis grade and quality of life assessments. Enrolment started in November 2017 with allocation of patients to one of the study groups by means of randomisation. Patients will be treated either withArrabidaea chicaor laser until wound healing. Monitoring includes daily assessment of mucositis grade and diameter measurement by photographs and millimetre periodontal probe. Treatments will be concluded once mucositis is healed. A blinded assessor will evaluate mucositis cure after referred by the study team. At this point, the gel tube will be weighed to indirectly assess patient’s compliance. At close-out, data will be analysed by a blinded researcher following the procedures described in the statistical analyses.Ethics and disseminationThis clinical trial was approved by the ethics committee of research in humans at the Faculty of Medical Sciences of University of Campinas (report no. 1,613,563/2016). Results from this trial will be communicated in peer-reviewed publications and scientific presentations.Trial registration numberRBR-5×4397.

A randomized clinical trial on the efficacy of a patient-adapted autonomous exercise regime for patients with head and neck cancer

2020 ◽  
Vol 48 (3) ◽  
pp. 187-192
Author(s):  
Julius Steegmann ◽  
Alexander K. Bartella ◽  
Anita Kloss-Brandstätter ◽  
Mohammad Kamal ◽  
Frank Hölzle ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Randomized Clinical Trial ◽  
Neck Cancer ◽  
Exercise Regime

scholarly journals Minocycline for symptom reduction during radiation therapy for head and neck cancer: a randomized clinical trial

2019 ◽  
Vol 28 (1) ◽  
pp. 261-269 ◽  
Author(s):  
G. Brandon Gunn ◽  
Tito R. Mendoza ◽  
Adam S. Garden ◽  
Xin Shelley Wang ◽  
Qiuling Shi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Randomized Clinical Trial ◽  
Neck Cancer ◽  
Symptom Reduction
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