Enhancing Immune System Functioning in AIDS Patients

1990 ◽  
Author(s):  
Keyword(s):  
Immune System ◽  
Aids Patients ◽  
System Functioning ◽  
Immune System Functioning

scholarly journals SOME ASPECTS OF IMMUNE SYSTEM FUNCTIONING IN HEALTHY DONORS SUBJECTED TO XENOGENOUS EXPOSURE

2014 ◽  
Vol 8 (1) ◽  
pp. 91 ◽  
Author(s):  
O. O. Obukhova ◽  
A. N. Trunov ◽  
O. M. Gorbenko ◽  
A. P. Shvajuk ◽  
A. V. Obukhov ◽  
...  
Keyword(s):  
Immune System ◽  
Healthy Donors ◽  
System Functioning ◽  
Immune System Functioning

scholarly journals Radionuclide activity and the immune system functioning in residents of radiation contaminated areas

2015 ◽  
Vol 6 (2) ◽  
pp. 93-96 ◽  
Author(s):  
V. L. Sokolenko ◽  
S. V. Sokolenko
Keyword(s):  
Immune System ◽  
T Lymphocytes ◽  
Blood Serum ◽  
Emotional Stress ◽  
Cortisol Level ◽  
Relative Number ◽  
System Functioning ◽  
Positive Correlations ◽  
Immune System Functioning ◽  
Radionuclide Activity

The objective of this research is to assess the relation of radioactive contamination degree to immune system functioning, in the absence or presence of additional potential immunosuppressants. To achieve the objective, during the period of 1995–2015 we examined 250 people, students of Cherkasy State University, who lived in the areas of enhanced radiation monitoring before. Also we evaluated the additional impact of the emotional stress caused by examinations on examined students. Indicators of cellular immunity were determined by immunophenotyping and dyeing using Romanowsky-Giemsa method. The level of immunoglobulins in blood serum was determined by radial immunodiffusion (Mancini method). The level of cortisol in blood serum was determined by immunoenzyme method. We have found that in absence of the emotional stress among residents of the areas contaminated with radionuclides, cortisol level remained at the upper limit of homeostatic norm. There is an average positive correlation between the activity of radionuclides in the territories of residence and the level of cortisol. There are marked average positive correlations between the activity of radionuclides and the level of neutrophils, and low positive correlations with the levels of IgG and IgM in blood serum. Average negative correlations between the activity of radionuclides and the following parameters are also observed: absolute and relative number of functionally mature T-lymphocytes with phenotype CD3+, absolute and relative number of their helper subpopulation CD4+, absolute and relative number of natural killer cells with phenotype CD16+; and strong negative correlations with immunoregulatory index CD4+/CD8+. Cortisol level shows the similar correlation with the same parameters, but correlation coefficient is lower. Under conditions of additional stress, caused by emotional load during the examinations, cortisol level significantly increases. This enhanced previously discovered correlations and revealed new ones: average negative correlations between radionuclide activity / cortisol level and expression of pan-T cell marker CD5, medium positive correlations with absolute and relative number of suppressor T-lymphocytes with phenotype CD8+, correlation with the level of serum IgG changes from positive to negative. Additional short-term stress factor combined with chronic influence of low doses of radiation increases the dependence of immunosuppression, caused by radiation contamination of the areas where examined students live, and causes failures in the work of compensatory mechanisms, particularly at the level of serum immunoglobulin products. 

Humor and immune-system functioning

1990 ◽  
Vol 3 (3) ◽  
Author(s):  
HERBERT M. LEFCOURT ◽  
KARINA DAVIDSON-KATZ ◽  
KAREN KUENEMAN
Keyword(s):  
Immune System ◽  
System Functioning ◽  
Immune System Functioning

scholarly journals Effect of Short-Term Desiccation, Recovery Time, and CAPA–PVK Neuropeptide on the Immune System of the Burying Beetle Nicrophorus vespilloides

2021 ◽  
Vol 12 ◽  
Author(s):  
Arkadiusz Urbański ◽  
Karolina Walkowiak-Nowicka ◽  
Grzegorz Nowicki ◽  
Szymon Chowański ◽  
Grzegorz Rosiński
Keyword(s):  
Immune System ◽  
Water Loss ◽  
Recovery Time ◽  
Control Level ◽  
Stress Factors ◽  
Burying Beetle ◽  
Short Term ◽  
Nicrophorus Vespilloides ◽  
System Functioning ◽  
Immune System Functioning

Environmental conditions, especially related to winter, are crucial for shaping activity of insect immune system. However, our previous research clearly indicates differences in the immune system functioning when the cold stress was induced in the laboratory conditions and when the beetles were collected from natural environment during winter. This is probably related to the multiplication of observed effects by simultaneous presence of different stress factors characteristic of winter, including desiccation. For these reasons, our next step was analysis of the effects of short-term desiccation and recovery time on the functioning of immune system of burying beetle Nicrophorus vespilloides. Also, the effect of Tenmo–PVK-2 (tenebrionid periviscerokinin), member of the CAPA–PVK neuropeptide family, was investigated to better understand observed changes. Short-term desiccation decreases the phagocytic activity of burying beetle haemocytes, which is correlated with a reduction in their adhesive ability. On the other hand, there was a significant increase in phenoloxidase (PO) activity and the level of proPO expression, which may suggest sealing the cuticula by melanin deposition and prevention of water loss. Additionally, the elevated level of defensin expression may be associated with the cross-talk between mechanisms, which participate in insect response to environmental stress, including pathogen infection. After 1 h of recovery time, the activity of tested cellular and humoral mechanisms was mostly back to the control level. However, inhibition of the activity of PO and down-regulation of proPO were noted. These results also indicate importance of melanin deposition during water loss. Moreover, it suggests that some changes in immune system functioning during stress conditions do not have an immune function. Interestingly, part of the effects characteristic of recovery time were also observed after the application of Tenmo–PVK-2, mainly related to haemocyte morphology. These results indicate that CAPA–PVK neuropeptides may also influence on activity of burying beetle immune system. It should be also highlighted that, because of the study of the effects of CAPA–PVK neuropeptides, homologs of vertebrate neuromedin U, the results may be interesting for search evolutionary similarities in the functioning of the neuroendocrine system of insects and vertebrates.

scholarly journals Peculiarities of immune system functioning of patients with endometrium cancer depending on the tumor differentiation grade

2004 ◽  
Vol 3 (4) ◽  
pp. 15-20
Author(s):  
A. I. Pashov ◽  
V. B. Tskhai ◽  
N. I. Kamzalakova ◽  
L. N. Platonova
Keyword(s):  
Immune System ◽  
Functional Abilities ◽  
Tumor Differentiation ◽  
Women Patients ◽  
Immune System Activation ◽  
System Functioning ◽  
System Activation ◽  
Stage Estimation ◽  
Immune System Functioning ◽  
Made In

The aim of investigation is to define the peculiarities of immune system functioning of patients with endometrium cancer depending on the tumor differentiation grade. 133 female patients of comparable age in menopause have been examined: healthy women, patients with histological verified high-, medium- (1-st group) and low-differentiated (2-nd group) endometrium adenocarcinoma of the I stage. Estimation of the immune state has been made in accordance with generally accepted recommendations. Immune system activation has been stated in the 1-st group, in the 2-nd group there has been marked a dissociation of the function of basic immune system chains and a decrease of their functional abilities.

Features of the immune system functioning during physiological pregnancy and their relationship with vaccination against influenza

2016 ◽  
Vol 18 (6) ◽  
pp. 59-62 ◽  
Author(s):  
M.P. Kostinov ◽  
◽  
E.A. Khromova ◽  
A.A. Savisko ◽  
A.M. Kostinova ◽  
...  
Keyword(s):  
Immune System ◽  
System Functioning ◽  
Immune System Functioning
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