Tardive Dyskinesia in Elderly Patients

1992 ◽  
Author(s):  
R. Yassa ◽  
C. Natase ◽  
D. Dupont ◽  
M. Thibeau
Keyword(s):  
Elderly Patients ◽  
Tardive Dyskinesia

Clinical Experience with Aripiprazole Treatment in Ten Elderly Patients with Schizophrenia or Schizoaffective Disorder: Retrospective Case Studies

CNS Spectrums ◽  
2004 ◽  
Vol 9 (11) ◽  
pp. 862-867 ◽  
Author(s):  
Subramoniam Madhusoodanan ◽  
Ronald Brenner ◽  
Sanjay Gupta ◽  
Harsha Reddy ◽  
Olivera Bogunovic
Keyword(s):  
Elderly Patients ◽  
Tardive Dyskinesia ◽  
Clinical Global Impression ◽  
Schizoaffective Disorder ◽  
Negative Symptoms ◽  
Clinical Symptoms ◽  
Retrospective Case ◽  
Clinical Global Impression Scale ◽  
Scale Scores ◽  
Positive And Negative Symptoms

ABSTRACTBackground: Clinical trials of aripiprazole, a recentl Food and Drug Administration-approved atypical antipsychotic, included elderly patients, but more data are needed on the effects of aripiprazole in this population, especially those with comorbid medical illnesses.Objective: To assess the response and safety of aripiprazole treatment in elderly patients with phrenia or schizoaffective disorder.Method: Data was obtained by retrospective review of medical records. Aripiprazole was used to treat 10 elderly hospitalized patients between 62 and 85 years of age who manifested signs of psychosis related to schizophrenia or schizoaffective disorder. All patients had been treated previously with atypical and classic antipsychotics. Response was assessed by clinical observation of patients' behavior and Clinical Global Impression Scale assigned retrospectively.Results: Seven patients responded to treatment, two did not respond, and one had a partial response. The mean Clinical Global Impression Scale scores improved from 6 (severely ill) at baseline to 2.3 (much improved) at discharge. Treatment was discontinued in the two patients who did not respond. Of the seven patients who responded, four presented with positive symptoms and showed significant improvement while three presented with positive and negative symptoms and both symptoms improved significantly. Four patients had preexisting extrapyramidal symptoms (EPS) and these symptoms decreased in three patients. In addition, two patients were able to discontinue antiparkinson medications. One patient who had severe tardive dyskinesia showed significant improvement in the dyskinetic symptoms. Four patients showed postural hypotension (without clinical symptoms) which resolved over time without treatment. Six patients showed a mean weight loss of 5.2 lbs. No adverse consequences occurred when divalproex sodium, carbamazepine, clonazepam or citalopram were given concurrently.Conclusion: The reduction of both positive and negative symptoms of schizophrenia and the lack of significant EPS, tardive dyskinesia, sedation, weight gain, anticholinergic effects, and QTc prolongation gives preliminary indication that aripiprazole may be a safe and effective medication for elderly patients with schizophrenia or schizoaffective disorder.

Changes in Tardive Dyskinesia Symptoms in Elderly Patients Treated with Ganglioside GM1 or Placebo

1994 ◽  
Vol 7 (4) ◽  
pp. 234-237 ◽  
Author(s):  
Barbara R. Sommer ◽  
Bruce M. Cohen ◽  
Andrew Satlin ◽  
Jonathan O. Cole ◽  
Lina Jandorf ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Tardive Dyskinesia ◽  
Ganglioside Gm1

Low Incidence of Persistent Tardive Dyskinesia in Elderly Patients With Dementia Treated With Risperidone

2000 ◽  
Vol 157 (7) ◽  
pp. 1150-1155 ◽  
Author(s):  
Dilip V. Jeste ◽  
Akiko Okamoto ◽  
Judy Napolitano ◽  
John M. Kane ◽  
Rick A. Martinez
Keyword(s):  
Elderly Patients ◽  
Tardive Dyskinesia ◽  
Low Incidence

Neuroleptics under High Risk Conditions*

1983 ◽  
Vol 28 (5) ◽  
pp. 398-403 ◽  
Author(s):  
L. K. Oyewumi
Keyword(s):  
Clinical Practice ◽  
High Risk ◽  
Sexual Dysfunction ◽  
Elderly Patients ◽  
Tardive Dyskinesia ◽  
Psychiatric Patients ◽  
The Elderly ◽  
Child Bearing ◽  
Nursing Mothers ◽  
Suicidal Patients

A critical review of various high risk situations in which neuroleptics could be used and have been used in clinical practice is presented. These high risk situations include: women of child bearing age (pregnant women, lactating and/or nursing mothers), the two extremes of life (children and the elderly), patients with sexual dysfunction, patients with tardive dyskinesia, non-psychotic psychiatric patients, physically ill and suicidal patients. The extraordinary applications of these drugs, such as for rapid tranquilization and megadose regimens are examined. The author provides guidelines for the use of neuroleptics in these clinical situations.

Sign in / Sign up

Export Citation Format

Share Document