Free Testosterone Predicts Memory, Cognition in Older Men

2002 ◽  
Author(s):  
Keyword(s):  
Free Testosterone ◽  
Older Men

scholarly journals In men older than 70 years, total testosterone remains stable while free testosterone declines with age. The Health in Men Study

2007 ◽  
Vol 156 (5) ◽  
pp. 585-594 ◽  
Author(s):  
Bu B Yeap ◽  
Osvaldo P Almeida ◽  
Zoë Hyde ◽  
Paul E Norman ◽  
S A Paul Chubb ◽  
...  
Keyword(s):  
Free Testosterone ◽  
Older Men ◽  
Early Morning ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Limited Data ◽  
Cross Sectional ◽  
Testosterone Concentration ◽  
Age Related ◽  
Clinical Consequences

Objective: An age-related decline in serum total and free testosterone concentration may contribute to ill health in men, but limited data are available for men > 70 years of age. We sought to determine the distribution and associations of reduced testosterone concentrations in older men. Design: The Health in Men Study is a community-representative prospective cohort investigation of 4263 men aged ≥ 70 years. Cross-sectional hormone data from 3645 men were analysed. Methods: Early morning sera were assayed for total testosterone, sex hormone binding globulin (SHBG) and LH. Free testosterone was calculated using the Vermeulen method. Results: Mean (± s.d.) serum total testosterone was 15.4 ± 5.6 nmol/l (444 ± 162 ng/dl), SHBG 42.4 ± 16.7 nmol/l and free testosterone 278 ± 96 pmol/l (8.01 ± 2.78 ng/dl). Total testosterone correlated with SHBG (Spearman’s r = 0.6, P < 0.0001). LH and SHBG increased with age (r = 0.2, P < 0.0001 for both). Instead of declining, total testosterone increased marginally (r = 0.04, P = 0.007) whilst free testosterone declined with age (r = −0.1, P < 0.0001). Free testosterone was inversely correlated with LH (r = −0.1, P < 0.0001). In multivariate analyses, increasing age, body mass index (BMI) and LH were associated with lower free testosterone. Conclusions: In men aged 70–89 years, modulation of androgen action may occur via an age-related increase in SHBG and reduction in free testosterone without a decline in total testosterone concentration. Increasing age, BMI and LH are independently associated with lower free testosterone. Further investigation would be required to assess the clinical consequences of low serum free testosterone, particularly in older men in whom total testosterone may be preserved.

Low Free Testosterone Level Predicts Frailty in Older Men. The Health in Men Study.

2010 ◽  
pp. OR17-3-OR17-3
Author(s):  
Z Hyde ◽  
L Flicker ◽  
OP Almeida ◽  
GJ Hankey ◽  
K McCaul ◽  
...  
Keyword(s):  
Testosterone Level ◽  
Free Testosterone ◽  
Older Men ◽  
Free Testosterone Level

Effects of heavy-resistance training on hormonal response patterns in younger vs. older men

1999 ◽  
Vol 87 (3) ◽  
pp. 982-992 ◽  
Author(s):  
William J. Kraemer ◽  
Keijo Häkkinen ◽  
Robert U. Newton ◽  
Bradley C. Nindl ◽  
Jeff S. Volek ◽  
...  
Keyword(s):  
Resistance Training ◽  
Training Program ◽  
Free Testosterone ◽  
Older Men ◽  
Total Testosterone ◽  
Igf I ◽  
Before And After ◽  
Igf Binding ◽  
Heavy Resistance Training ◽  
Igf Binding Protein

To examine the adaptations of the endocrine system to heavy-resistance training in younger vs. older men, two groups of men (30 and 62 yr old) participated in a 10-wk periodized strength-power training program. Blood was obtained before, immediately after, and 5, 15, and 30 min after exercise at rest before and after training and at rest at −3, 0, 6, and 10 wk for analysis of total testosterone, free testosterone, cortisol, growth hormone, lactate, and ACTH analysis. Resting values for insulin-like growth factor (IGF)-I and IGF-binding protein-3 were determined before and after training. A heavy-resistance exercise test was used to evaluate the exercise-induced responses (4 sets of 10-repetition maximum squats with 90 s of rest between sets). Squat strength and thigh muscle cross-sectional area increased for both groups. The younger group demonstrated higher total and free testosterone and IGF-I than the older men, training-induced increases in free testosterone at rest and with exercise, and increases in resting IGF-binding protein-3. With training the older group demonstrated a significant increase in total testosterone in response to exercise stress along with significant decreases in resting cortisol. These data indicate that older men do respond with an enhanced hormonal profile in the early phase of a resistance training program, but the response is different from that of younger men.

Low free testosterone levels are associated with prevalence and incidence of depressive symptoms in older men

2010 ◽  
Vol 72 (2) ◽  
pp. 232-240 ◽  
Author(s):  
Devina Joshi ◽  
Natasja M. van Schoor ◽  
Willem de Ronde ◽  
Laura A. Schaap ◽  
Hannie C. Comijs ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Free Testosterone ◽  
Older Men ◽  
Testosterone Levels

scholarly journals Elevated LH predicts ischaemic heart disease events in older men: the Health in Men Study

2011 ◽  
Vol 164 (4) ◽  
pp. 569-577 ◽  
Author(s):  
Zoë Hyde ◽  
Paul E Norman ◽  
Leon Flicker ◽  
Graeme J Hankey ◽  
Kieran A McCaul ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Ischaemic Heart Disease ◽  
Free Testosterone ◽  
Older Men ◽  
Community Dwelling ◽  
Mass Action ◽  
Age Related

ContextHypogonadism in men is associated with insulin resistance, elevations in pro-inflammatory cytokines and fibrinogen, and an atherogenic lipid profile. However, it is uncertain whether the age-related decline in testosterone is associated with ischaemic heart disease (IHD) events.ObjectiveTo determine whether testosterone and its associated hormones, sex hormone-binding globulin (SHBG) and LH, predict IHD events in older men.DesignProspective cohort study.MethodsBetween 2001 and 2004, 3637 community-dwelling men aged 70–88 years underwent a clinical assessment of cardiovascular risk factors and biochemical assessment of testosterone, SHBG and LH. Free testosterone was calculated using mass action equations. Participants were followed until December 2008 using electronic record linkage to capture IHD events (hospital admission or death).ResultsMean follow-up was 5.1 years. During this period, 618 men (17.0%; 95% confidence interval (CI) 15.8, 18.3%) experienced an event, of which 160 were fatal. Men with higher baseline total or free testosterone levels experienced fewer IHD events (hazard ratio (HR)=0.89; 95% CI 0.82, 0.97 and HR=0.86; 95% CI 0.79, 0.94 for each one s.d. increase in total and free testosterone respectively). These associations were maintained after adjustment for age and waist:hip ratio but did not persist after adjustment for prevalent IHD or other cardiovascular risk factors. SHBG was not associated with IHD events. In contrast, higher LH levels were associated with reduced event-free survival in both univariate (HR=1.15; 95% CI 1.08, 1.22) and adjusted analyses (HR=1.08; 95% CI 1.01, 1.15).ConclusionsDysregulation of the hypothalamic–pituitary–gonadal axis may be a risk factor for IHD. Further studies of men with either elevated LH or low testosterone are warranted.

scholarly journals Low Free Testosterone Concentration as a Potentially Treatable Cause of Depressive Symptoms in Older Men

2008 ◽  
Vol 65 (3) ◽  
pp. 283 ◽  
Author(s):  
Osvaldo P. Almeida ◽  
Bu B. Yeap ◽  
Graeme J. Hankey ◽  
Konrad Jamrozik ◽  
Leon Flicker
Keyword(s):  
Depressive Symptoms ◽  
Free Testosterone ◽  
Older Men ◽  
Testosterone Concentration

scholarly journals Testosterone profile in older men with Alzheimer's disease

2008 ◽  
Vol 2 (4) ◽  
pp. 289-293
Author(s):  
Cristiana Roscito Arenella Dusi ◽  
Lílian Schafirovits Morillo ◽  
Regina Miksian Magaldi ◽  
Adriana Nunes Machado ◽  
Sami Liberman ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Free Testosterone ◽  
Older Men ◽  
Sex Hormone Binding Globulin ◽  
Control Group ◽  
Total Testosterone ◽  
Chi Square ◽  
Testosterone Levels ◽  
Significant Difference

Abstract Evidence suggests low testosterone levels in Alzheimer's disease. Objectives: To compare testosterone levels between older men with and without Alzheimer's disease. Methods: Fourteen men with Alzheimer's disease were compared with twenty eight men without dementia. Demographic variables and clinical profiles were analyzed. Within fifteen days before or after the described evaluation, measures of total testosterone and Sex Hormone Binding Globulin (SHBG) were performed. Free testosterone level was calculated based on total testosterone and SHBG. Quantitative variables were analyzed using Student's t test or Kruskal-Wallis test, while qualitative variables were analyzed using chi-square or Fisher test. Results: Mean age in the Control and Alzheimer's disease groups were 72.0 (SD±4.8) years and 79.3(SD±5.9) years, respectively (p=0.001). Mean schooling between these two groups were 8.78 and (±5.86) years, respectively (p=0.022). There were no statistically significant differences between the two groups for testosterone levels, although a trend was observed for the Alzheimer's disease group to present lower levels than the control group (p=0.066). There was no direct correlation between free testosterone and age, although a trend was evident (p=0.068). Conclusions: There was no significant difference in testosterone between men with AD and those without dementia.

Combination of low free testosterone and low vitamin D predicts mortality in older men referred for coronary angiography

2012 ◽  
Vol 77 (3) ◽  
pp. 475-483 ◽  
Author(s):  
Elisabeth Lerchbaum ◽  
Stefan Pilz ◽  
Bernhard O. Boehm ◽  
Tanja B. Grammer ◽  
Barbara Obermayer-Pietsch ◽  
...  
Keyword(s):  
Vitamin D ◽  
Coronary Angiography ◽  
Free Testosterone ◽  
Older Men

scholarly journals Relationship of chronic endurance exercise to the somatotropic and sex hormone status of older men

1998 ◽  
pp. 517-523 ◽  
Author(s):  
CS Cooper ◽  
DR Taaffe ◽  
D Guido ◽  
E Packer ◽  
L Holloway ◽  
...  
Keyword(s):  
Body Composition ◽  
Muscle Strength ◽  
Endurance Exercise ◽  
Free Testosterone ◽  
Older Men ◽  
Sex Hormone ◽  
Group Differences ◽  
Total Testosterone ◽  
Free Androgen Index ◽  
Igf I

To investigate putative abrogating effects of habitual endurance exercise on age-related changes in endocrine function and body composition, we compared insulin-like growth factor-I (IGF-I), sex hormonal status and body composition in 15 Masters runners and 15 minimally exercising men (MEM) aged 60-70 years. A higher maximal oxygen uptake (VO2 max.) in the runners (41.4+/-1.6 compared with 27.3+/-1.4 ml/kg/min, P=0.0001; mean+/-S.E.M.) reflected our group allocations. Analysis of body composition and bone mineral density (BMD) by dual energy X-ray absorptiometry showed no group differences in lean tissue mass or in regional or whole body BMD, but MEM were heavier, reflecting greater adiposity. Of nine muscle groups tested, only quadriceps strength differed significantly, being greater in runners (60.3+/-2.8 compared with 51.1+/-2.3 kg, P=0.02). Total IGF-I (129+/-10 compared with 124+/-11 ng/ml, P=0.72) and IGF-binding protein-3 (2854+/-94 compared with 2623+/-128ng/ml, P=0.16), were similarly depressed compared with young adult norms in both groups. There was no relationship between total or bioavailable IGF-I and any body composition, BMD or muscle strength variable. In the runners, concentrations of total testosterone (19.1+/-0.8 compared with 15.0+/-0.9 nmol/l, P=0.002) and sex hormone binding globulin (SHBG) (124.4+/-21.6 compared with 67.7+/-11.6 nmol/l, P=0.03) were significantly greater, but the free androgen index was significantly lower (20.7+/-2.7 compared with 31.4+/-4.1, P=0.04). Directly measured free testosterone, however, was similar between the runners and MEM (47.9+/-1.8 compared with 47.1+/-2.0 nmol/l P=0.80). Therefore the group differences in total testosterone and free androgen index were due to their different SHBG concentrations. Although estrone concentration was higher in MEM (85.1+/-5.2 compared with 108+/-6.7 pmol/l, P=0.03), estradiol concentration was similar between groups (73.0+/-6.3 compared with 81.8+/-8.0 pmol/l, P=0.18), indicating that estrogens were not responsible for the increased SHBG in runners. These results indicate that even high levels of regular endurance exercise do not prevent the decline in the somatotropic axis that occurs with aging. Furthermore, the somatic effects of exercise in older men (reduced adiposity and increased regional muscle strength) occurred independently of somatotropic or androgen status. Although habitual exercise does not influence free testosterone concentrations in older men, it appears to enhance the age-associated increase in SHBG synthesis.

Sign in / Sign up

Export Citation Format

Share Document