Court briefs undergo complex preparation

1987 ◽  
Author(s):  
John Bales
Keyword(s):  
Complex Preparation

Growth Retardation of Poorly Transfectable Tumor by Multiple Injections of Plasmids Encoding PE40 Based Targeted Toxin Complexed with Polyethylenimine

2020 ◽  
Vol 20 (4) ◽  
pp. 289-296
Author(s):  
Yuriy Khodarovich ◽  
Darya Rakhmaninova ◽  
German Kagarlitskiy ◽  
Anastasia Baryshnikova ◽  
Sergey Deyev
Keyword(s):  
Growth Retardation ◽  
Bystander Effect ◽  
Dna Encoding ◽  
Complex Preparation ◽  
Human Telomerase ◽  
Linear Polyethylenimine ◽  
Cag Promoter ◽  
Targeted Toxin

Background:: One of the approaches to cancer gene therapy relies on tumor transfection with DNA encoding toxins under the control of tumor-specific promoters. Methods:: Here, we used DNA plasmids encoding very potent anti-ERBB2 targeted toxin, driven by the human telomerase promoter or by the ubiquitous CAG promoter (pTERT-ETA and pCAG-ETA) and linear polyethylenimine to target cancer cells. Results:: We showed that the selectivity of cancer cell killing by the pTERT-ETA plasmid is highly dependent upon the method of preparation of DNA-polyethylenimine complexes. After adjustment of complex preparation protocol, cell lines with high activity of telomerase promoter can be selectively killed by transfection with the pTERT-ETA plasmid. We also showed that cells transfected with pTERT-ETA and pCAG-ETA plasmids do not exert any detectable bystander effect in vitro. Conclusion:: Despite this, three intratumoral injections of a plasmid-polyethylenimine complex resulted in substantial growth retardation of a poorly transfectable D2F2/E2 tumor in mice. There were no significant differences in anti-tumor properties between DNA constructs with telomerase or CAG promoters in vivo.

Mechanochemical synthesis of an Eu(III) complex. Preparation and Luminescence Properties of PMMA:[C42H38N5O19Eu] Hybrid Films

Polyhedron ◽  
2015 ◽  
Vol 85 ◽  
pp. 10-14 ◽  
Author(s):  
Sara Rodríguez ◽  
Perla Elizondo ◽  
Sylvain Bernès ◽  
Nancy Pérez ◽  
Ricardo Bustos ◽  
...  
Keyword(s):  
Mechanochemical Synthesis ◽  
Luminescence Properties ◽  
Hybrid Films ◽  
Complex Preparation

Bio-skin inspired 3D porous cellulose/AlPO4 nano-laminated film with structure-enhanced selective emission for all-day non-power cooling

2021 ◽  
Author(s):  
Shuangjiang Feng ◽  
Yuming Zhou ◽  
Xi Chen ◽  
Shengnan Shi ◽  
Chenghuan Liu ◽  
...  
Keyword(s):  
Radiative Cooling ◽  
Preparation Technology ◽  
Cellulose Films ◽  
Highly Efficient ◽  
Atmospheric Window ◽  
Complex Preparation

Porous cellulose films have been reported as sustainable and highly-efficient non-power radiative cooling (PRC) materials but still challenged by their insufficient atmospheric window (AM) emissivity and complex preparation technology. Herein,...

scholarly journals THE EFFECTIVENES OF COMPLEX DRUG “BIFIDUM BAG” FOR STATUS CORRECTION OF LARGE INTESTINE MICROBOICENOSIS AND ANTIOXIDANT PROPERTIES OF COLONOCYTES IN EXPERIMENTAL DYSBIOSIS

2019 ◽  
Vol 23 (2) ◽  
pp. 203-210
Author(s):  
O. A. Medvedeva ◽  
V. A. Korolev ◽  
N. A. Verevkina ◽  
V. A. Riadnova
Keyword(s):  
Superoxide Dismutase ◽  
Large Intestine ◽  
Antioxidant Properties ◽  
Malonic Dialdehyde ◽  
The State ◽  
Control Group ◽  
Experimental Animals ◽  
Bacteriological Method ◽  
Complex Preparation ◽  
Complex Drug

The effectiveness of complex drug “Bifidum BAG” for status correction of large intestine microbiocenosis and antioxidant properties of colonocytes in experimental dysbiosis has been studied. Acomplex drug was administered to experimental animals, which includes Bifidobacterium and Dihydroquercetin. Quantitative and qualitative study of large intestine was done in mices by bacteriological method. The state of lipid peroxidation system was evaluatedaccoding to the content of acylhydroperoxide and malonic dialdehyde. The state of antioxidant protective system was reached by means of catalase and superoxide dismutase activity. Experimental dysbiosis was shown as significant changes in mucosal microflora, changes colonocytes antioxidant properties. The use of the complex preparation “Bifidum BAG”, led to the normalization of the colon microbiota (11 of 16 microorganisms were recovered). After correction gentamicin-associated dysbiosis with a complex probiotic, a positive effect of the drug on the colonocytes antioxidant defense was noted. So the activity of catalase increased 1.1 times, compared with the determined index in the group “dysbiosis”. The activity of superoxide dismutase increased 2 times in comparison with the group “dysbiosis”, exceeding the value of the control group. The concentration of LPO products in colonocytes of experimental animals decreased significantly. The content of malonicdialdehyde and acylhydroperoxide decreased 1.6 times and 5.6 times in comparison with the determined index of the group “dysbiosis”, respectively.

scholarly journals COMPREHENSIVE PROGRAM AGAINST EXOAND ENDOGENOUS STAGES OF COCCIDIA IN PIG

2020 ◽  
pp. 346-352
Author(s):  
Rinat Safiullin
Keyword(s):  
Sodium Hydroxide Solution ◽  
Physiological Solution ◽  
The Body ◽  
Recommended Dose ◽  
Definite Effect ◽  
Combined Use ◽  
Negative Effect ◽  
Complex Preparation ◽  
Biological Protection ◽  
Endogenous Stages

Coccidiosis (isosporiasis, eimeriosis) and balantidiasis are most common among endamebas, which affect pigs of different age but they have the greatest negative effect on young animals. The work was carried out in a sow house at a pig complex in the Moscow Region. The sow house was divided into four sectors with 40 sows each. Complex preparation Kenocox 4% and Emeriocide 5% at a recommended dose and exposure were used for disinfestation during the preparation of the sow house in sectors 1 and 2. The recommended dose of 4% hot sodium hydroxide solution (basic version) was used for disinvasion of sectors 3 and 4. Piglets were taken from the mother at the age of 23 days at this farm. Piglets from sectors 1 and 2 were prescribed Toltrazuril 5% at a dose of the active substance of 30 mg / kg of the body weight after farrowing on the 3rd to 5th days of age as a preventive course. Piglets from sectors 3 and 4 served as a control and were prescribed physiological solution at a single dose of 1 ml orally. The combined use of drugs against the exogenous and endogenous stages of Coccidia significantly improved the level of biological protection of the sow house, which had a definite effect on production and economic results.

scholarly journals TO THE QUESTION ABOUT THE PREDICTORS OF VICTIM BEHAVIOR OF YOUNGER SCHOOL CHILDREN

2021 ◽  
pp. 176-184
Author(s):  
Ольга Федоровна Афанасьева
Keyword(s):  
School Children ◽  
Deviant Behavior ◽  
The State ◽  
Low Level ◽  
Primary Schoolchildren ◽  
Readiness To Learn ◽  
Complex Preparation ◽  
The Relationship

Рассматриваются аспекты виктимного поведения младших школьников, связанные с готовностью ребенка к обучению в школе, процессом его адаптации и проявлениями состояния тревожности. Обозначены психологические основания комплексной подготовки к школе и последствия низкого уровня готовности. Описываются результаты исследования, направленного на определение взаимосвязи недостаточной готовности к школе и уровня тревожности, которые могут стать причиной проявления отклоняющегося поведения, в частности виктимности. The aspects of victim behavior of primary schoolchildren are considered, which are connected with the child's readiness to learn at school, the process of his adaptation and manifestations of the state of anxiety. The psychological foundations of complex preparation for school and the consequences of a low level of readiness are outlined. The article describes the results of a study aimed at determining the relationship between insufficient readiness for school and the level of anxiety, which can cause the manifestation of deviant behavior, in particular, victimization.

scholarly journals Biotechnological aspects of the use of complex preparation 1-ethoxysilatrane with crezacin in crop production

2019 ◽  
Vol 60 (11) ◽  
pp. 69-74
Author(s):  
Valery N. Zelenkov ◽  
◽  
Vladimir N. Petrichenko ◽  
Anatoly A. Lapin ◽  
Viktor P. Baryshok ◽  
...  
Keyword(s):  
Plant Growth ◽  
Plant Growth Regulators ◽  
Growth Regulators ◽  
Crop Production ◽  
High Efficiency ◽  
New Drugs ◽  
Tree Leaves ◽  
Apple Leaves ◽  
Foliar Treatment ◽  
Complex Preparation

Currently, the expansion of research to find new efficient and environmentally friendly plant growth regulators is an urgent task of agricultural biotechnology. One of the main requirements of the modern development of crop production using technologies for the use of new plant growth regulators is, along with the environmental friendliness of new drugs, both at the application stage for foliar feeding of plants and improving the quality of the final product. One of the new drugs that meet these requirements is a complex preparation of 1-ethoxysilatrane with crezacin. The work shows the high efficiency of the use of the new apple growth regulator in the processing of apple leaves. As a result of the studies, a synergism of the joint action of 1-ethoxysilatrane and crezacin as part of a complex preparation was revealed during foliar treatment of apple leaves of 3-4 phases and the beginning of flowering by spraying the drug in doses of 15 g/ha. The total increase in apple harvest during foliar treatment of tree leaves was 8.1% or 7.0 t/ha compared with the control. An increase in the quality indicators of gardening products was revealed when using the drug 1-ethoxysilatran with krezacin in terms of the content of dry substances, total sugar, vitamin C and pectin in the fruits. The content in the fruits of nitrates during foliar treatment with a new preparation of tree leaves is reduced by 17.9% compared with the control. The content in the fruits of apples of nitrates during foliar treatment with a new preparation of tree leaves decreases by 17.9%, the lead content by 44% compared with the control.

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