Baboon (Papio anubis) chimeric face processing by human (Homo sapiens) judges: Influence of stimuli complexity on the perception of oro-facial asymmetries.

2019 ◽  
Vol 133 (1) ◽  
pp. 36-45
Author(s):  
Catherine Wallez ◽  
Jacques Vauclair ◽  
Marie Bourjade
2021 ◽  
Vol 42 (2) ◽  
pp. 186-191
Author(s):  
S. Sivagami ◽  
◽  
R. Rathna ◽  
S. Nagavignesh ◽  
N.V. Ghone ◽  
...  

Aim: To investigate the binding of human CD40 ligand (CD40L) mimetic molecule, 3-(dimethylamino)-1-phenyl-1-propanone hydrochloride (3-DPH), with CD40 receptor (CD40R) molecules of Homo sapiens, Cavia porcellus, Cricetulus griseus, Macaca mulatta, Mus musculus, Oryctolagus cuniculus, Papio anubis and Rattus norvegicus species using bioinformatics tool. Methodology: Three-dimensional structures of CD40Rs and CD40Ls for various mammalian species were generated using the published crystal structure of human CD40 receptor-ligand complex by homology modelling using SWISS-MODEL tool. Furthermore, human CD40L mimetic molecule, 3-DPH was docked against the generated CD40R of various mammalian species using AUTODOCK 4.2. Results: Docking studies revealed that documented HIS78 and GLN79 residues of human CD40R were the key interaction residues, which interacted with human CD40L and 3-DPH. The CD40Rs of H. sapiens, C. porcellus, C. griseus, M. mulatta, M. musculus, O. cuniculus, P. anubis, and R. norvegicus bind with 3-DPH with a binding energy -4.67, -5.22, -5.19, -4.62, -4.85, -4.63, -4.51, and -4.86 kcal/mol, respectively. Interpretation: Molecular docking studies provide crucial insight into the binding affinity and interaction of 3-DPH at the active site of CD40R of the respective mammalian species. O. cuniculus and M. musculus species were found to be appropriate animal models for further evaluation of the therapeutic effect of human CD40L mimetic molecule Key words: 3-DPH, Animal model, CD40R, CD40L, Homo sapeins, Molecular docking


Author(s):  
W. Krebs ◽  
I. Krebs

Various inclusion bodies occur in vertebrate retinal photoreceptor cells. Most of them are membrane bound and associated with phagocytosis or they are age related residual bodies. We found an additional inclusion body in foveal cone cells of the baboon (Papio anubis) retina.The eyes of a 15 year old baboon were fixed by immersion in cacodylate buffered glutaraldehyde (2%)/formaldehyde (2%) as described in detail elsewhere . Pieces of retina from various locations, including the fovea, were embedded in epoxy resin such that radial or tangential sections could be cut.Spindle shaped inclusion bodies were found in the cytoplasm of only foveal cones. They were abundant in the inner segments, close to the external limiting membrane (Fig. 1). But they also occurred in the outer fibers, the perikarya, and the inner fibers (Henle’s fibers) of the cone cells. The bodies were between 0.5 and 2 μm long. Their central diameter was 0.2 to 0. 3 μm. They always were oriented parallel to the long axis of the cone cells. In longitudinal sections (Figs. 2,3) they seemed to have a fibrous skeleton that, in cross sections, turned out to consist of plate-like (Fig.4) and tubular profiles (Fig. 5).


2010 ◽  
Vol 69 (3) ◽  
pp. 161-167 ◽  
Author(s):  
Jisien Yang ◽  
Adrian Schwaninger

Configural processing has been considered the major contributor to the face inversion effect (FIE) in face recognition. However, most researchers have only obtained the FIE with one specific ratio of configural alteration. It remains unclear whether the ratio of configural alteration itself can mediate the occurrence of the FIE. We aimed to clarify this issue by manipulating the configural information parametrically using six different ratios, ranging from 4% to 24%. Participants were asked to judge whether a pair of faces were entirely identical or different. The paired faces that were to be compared were presented either simultaneously (Experiment 1) or sequentially (Experiment 2). Both experiments revealed that the FIE was observed only when the ratio of configural alteration was in the intermediate range. These results indicate that even though the FIE has been frequently adopted as an index to examine the underlying mechanism of face processing, the emergence of the FIE is not robust with any configural alteration but dependent on the ratio of configural alteration.


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