Supplemental Material for Specific and Common Mediators of Gastrointestinal Symptom Improvement in Patients Undergoing Education/Support vs. Cognitive Behavioral Therapy for Irritable Bowel Syndrome

2021 ◽  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Cognitive Behavioral Therapy ◽  
Gastrointestinal Symptom ◽  
Behavioral Therapy ◽  
Cognitive Behavioral ◽  
Symptom Improvement ◽  
Irritable Bowel ◽  
Education Support

scholarly journals Cognitive behavioral therapy for irritable bowel syndrome induces bidirectional alterations in the brain-gut-microbiome axis associated with gastrointestinal symptom improvement

Microbiome ◽  
2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Jonathan P. Jacobs ◽  
Arpana Gupta ◽  
Ravi R. Bhatt ◽  
Jacob Brawer ◽  
Kan Gao ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Functional Connectivity ◽  
Cognitive Behavioral Therapy ◽  
Gut Microbiome ◽  
Behavioral Therapy ◽  
Cognitive Behavioral ◽  
Symptom Improvement ◽  
Abdominal Symptoms ◽  
Irritable Bowel ◽  
The Brain

Abstract Background There is growing recognition that bidirectional signaling between the digestive tract and the brain contributes to irritable bowel syndrome (IBS). We recently showed in a large randomized controlled trial that cognitive behavioral therapy (CBT) reduces IBS symptom severity. This study investigated whether baseline brain and gut microbiome parameters predict CBT response and whether response is associated with changes in the brain-gut-microbiome (BGM) axis. Methods Eighty-four Rome III-diagnosed IBS patients receiving CBT were drawn from the Irritable Bowel Syndrome Outcome Study (IBSOS; ClinicalTrials.gov NCT00738920) for multimodal brain imaging and psychological assessments at baseline and after study completion. Fecal samples were collected at baseline and post-treatment from 34 CBT recipients for 16S rRNA gene sequencing, untargeted metabolomics, and measurement of short-chain fatty acids. Clinical measures, brain functional connectivity and microstructure, and microbiome features associated with CBT response were identified by multivariate linear and negative binomial models. Results At baseline, CBT responders had increased fecal serotonin levels, and increased Clostridiales and decreased Bacteroides compared to non-responders. A random forests classifier containing 11 microbial genera predicted CBT response with high accuracy (AUROC 0.96). Following treatment, CBT responders demonstrated reduced functional connectivity in regions of the sensorimotor, brainstem, salience, and default mode networks and changes in white matter in the basal ganglia and other structures. Brain changes correlated with microbiome shifts including Bacteroides expansion in responders. Conclusions Pre-treatment intestinal microbiota and serotonin levels were associated with CBT response, suggesting that peripheral signals from the microbiota can modulate central processes affected by CBT that generate abdominal symptoms in IBS. CBT response is characterized by co-correlated shifts in brain networks and gut microbiome that may reflect top-down effects of the brain on the microbiome during CBT.

scholarly journals Irritable bowel syndrome treatment: cognitive behavioral therapy versus medical treatment

2012 ◽  
Vol 1 ◽  
pp. 123-129 ◽  
Author(s):  
Majid Mahvi-Shirazi ◽  
Ali Fathi-Ashtiani ◽  
Sayed-Kazem Rasoolzade-Tabatabaei ◽  
Mohsen Amini
Keyword(s):  
Irritable Bowel Syndrome ◽  
Cognitive Behavioral Therapy ◽  
Medical Treatment ◽  
Behavioral Therapy ◽  
Cognitive Behavioral ◽  
Irritable Bowel

scholarly journals Tu1612 – Centralized Sensitivity Phenotype As a Predictor of Outcome to Cognitive Behavioral Therapy for Irritable Bowel Syndrome

2019 ◽  
Vol 156 (6) ◽  
pp. S-1061-S-1062
Author(s):  
Brian M. Quigley ◽  
Gregory D. Gudleski ◽  
Bruce D. Naliboff ◽  
Jennifer S. Labus ◽  
Emeran A. Mayer ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Cognitive Behavioral Therapy ◽  
Behavioral Therapy ◽  
Cognitive Behavioral ◽  
Irritable Bowel

scholarly journals Durability and Decay of Treatment Benefit of Cognitive Behavioral Therapy for Irritable Bowel Syndrome

2019 ◽  
Vol 114 (2) ◽  
pp. 330-338 ◽  
Author(s):  
Jeffrey M. Lackner ◽  
James Jaccard ◽  
Christopher D. Radziwon ◽  
Rebecca S. Firth ◽  
Gregory D. Gudleski ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Cognitive Behavioral Therapy ◽  
Behavioral Therapy ◽  
Cognitive Behavioral ◽  
Treatment Benefit ◽  
Irritable Bowel
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