scholarly journals Applying experimental therapeutics to examine cognitive and chronological vulnerabilities as mediators of acute outcomes in cognitive-behavioral therapy and light therapy for winter depression.

2020 ◽  
Vol 88 (8) ◽  
pp. 786-797 ◽  
Author(s):  
Kelly J. Rohan ◽  
Keith B. Burt ◽  
Julia Camuso ◽  
Jessica Perez ◽  
Jonah Meyerhoff
Keyword(s):  
Cognitive Behavioral Therapy ◽  
Behavioral Therapy ◽  
Light Therapy ◽  
Cognitive Behavioral ◽  
Experimental Therapeutics ◽  
Winter Depression

scholarly journals Light Enhanced Cognitive Behavioral Therapy (CBT+) for Insomnia and Fatigue During Chemotherapy for Breast Cancer: A Randomized Controlled Trial

2021 ◽  
Author(s):  
Helena R Bean ◽  
Justine Diggens ◽  
Maria Ftanou ◽  
Marliese Alexander ◽  
Lesley Stafford ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cognitive Behavioral Therapy ◽  
Behavioral Therapy ◽  
Bright Light ◽  
Light Therapy ◽  
Cognitive Behavioral ◽  
Bright Light Therapy ◽  
Patient Reported ◽  
Insomnia Symptoms

Study Objectives Sleep problems are common during chemotherapy for breast cancer (BC). We evaluated whether combined brief cognitive behavioral and bright light therapy (CBT+) is superior to treatment as usual with relaxation audio (TAU+) for insomnia symptoms and sleep efficiency (primary outcomes). Methods We randomized women receiving intravenous chemotherapy, stratified by tumor stage and insomnia severity index (ISI), to 6-weeks CBT+ or TAU+. CBT+ included one in-person session, one telephone call, seven emails, and 20 minutes bright light each morning. TAU+ comprised usual treatment and two emails with relaxation audio tracks. Patient-reported outcomes were assessed at baseline, midpoint (week 3), post (week 6) and 3-month follow-up. Results Women (N = 101) were randomly assigned to CBT+ or TAU+. Insomnia symptoms declined significantly more from baseline to post with CBT+ versus TAU+ (-5.06 vs -1.93, P = .009; effect size [ES] = .69). At 3-month follow-up, both groups had improved insomnia symptoms but did not differ (ES = .18, P = .56). CBT+ had higher patient-reported sleep efficiency than TAU+ after the start of intervention (P = .05) and more improvement in fatigue (ES = .59, P = .013) and daytime sleep-related impairment (ES = .61, P = .009) from baseline to post. Conclusions CBT+ had a clinically significant impact on insomnia and fatigue with moderate effect sizes. Results support offering cognitive behavioral therapy for insomnia and bright light therapy during chemotherapy for breast cancer to help manage sleep and fatigue. Clinical trial information: Registered with the Australian New Zealand Clinical Trials Registry (http://anzctr.org.au/), Registration Number: ACTRN12618001255279

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