scholarly journals Inactivation of the interpositus nucleus during unpaired extinction does not prevent extinction of conditioned eyeblink responses or conditioning-specific reflex modification.

2019 ◽  
Vol 133 (4) ◽  
pp. 398-413
Author(s):  
Lauren B. Burhans ◽  
Bernard G. Schreurs
Keyword(s):  
Conditioned Eyeblink ◽  
Interpositus Nucleus ◽  
Reflex Modification

scholarly journals Hippocampal Interneurons are Required for Trace Eyeblink Conditioning in Mice

2021 ◽  
Author(s):  
Wei-Wei Zhang ◽  
Rong-Rong Li ◽  
Jie Zhang ◽  
Jie Yan ◽  
Qian-Hui Zhang ◽  
...  
Keyword(s):  
Eyeblink Conditioning ◽  
Pyramidal Cells ◽  
Conditioned Eyeblink ◽  
Cellular Mechanisms ◽  
Sustained Activity ◽  
Early Acquisition ◽  
Freely Moving ◽  
Trace Eyeblink Conditioning

AbstractWhile the hippocampus has been implicated in supporting the association among time-separated events, the underlying cellular mechanisms have not been fully clarified. Here, we combined in vivo multi-channel recording and optogenetics to investigate the activity of hippocampal interneurons in freely-moving mice performing a trace eyeblink conditioning (tEBC) task. We found that the hippocampal interneurons exhibited conditioned stimulus (CS)-evoked sustained activity, which predicted the performance of conditioned eyeblink responses (CRs) in the early acquisition of the tEBC. Consistent with this, greater proportions of hippocampal pyramidal cells showed CS-evoked decreased activity in the early acquisition of the tEBC. Moreover, optogenetic suppression of the sustained activity in hippocampal interneurons severely impaired acquisition of the tEBC. In contrast, suppression of the sustained activity of hippocampal interneurons had no effect on the performance of well-learned CRs. Our findings highlight the role of hippocampal interneurons in the tEBC, and point to a potential cellular mechanism subserving associative learning.

scholarly journals Dissociation of the blocking of conditioned eyeblink and conditioned fear following a shift in US locus

1996 ◽  
Vol 24 (4) ◽  
pp. 459-470 ◽  
Author(s):  
Stephanie L. Betts ◽  
Susan E. Brandon ◽  
Allan R. Wagner
Keyword(s):  
Conditioned Fear ◽  
Conditioned Eyeblink

Extracellular amino acid levels in the interpositus nucleus during classical eyeblink conditioning in alert cats.

2007 ◽  
Vol 121 (5) ◽  
pp. 1106-1112 ◽  
Author(s):  
Lydia Jiménez-Díaz ◽  
Agnès Gruart ◽  
Francisco Javier Miñano ◽  
José María Delgado-García
Keyword(s):  
Amino Acid ◽  
Eyeblink Conditioning ◽  
Interpositus Nucleus ◽  
Amino Acid Levels ◽  
Alert Cats ◽  
Extracellular Amino Acid
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