scholarly journals Early life stress impairs contextual threat expression in female, but not male, mice.

2018 ◽  
Vol 132 (4) ◽  
pp. 247-257 ◽  
Author(s):  
Gabriela Manzano-Nieves ◽  
Mizan Gaillard ◽  
Meghan Gallo ◽  
Kevin G. Bath
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Male Mice

scholarly journals Effects of early-life stress on peripheral and central mitochondria in male mice across ages

2021 ◽  
pp. 105346
Author(s):  
S.R. Ruigrok ◽  
K. Yim ◽  
T.L. Emmerzaal ◽  
B. Geenen ◽  
N. Stöberl ◽  
...  
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Male Mice

scholarly journals Voluntary wheel running improves outcomes in an early life stress-induced model of urologic chronic pelvic pain syndrome in male mice

Pain ◽  
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Isabella M. Fuentes ◽  
Brittni M. Jones ◽  
Aaron D. Brake ◽  
Angela N. Pierce ◽  
Olivia C. Eller ◽  
...  
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Chronic Pelvic Pain ◽  
Wheel Running ◽  
Chronic Pelvic Pain Syndrome ◽  
Early Life Stress ◽  
Pain Syndrome ◽  
Pelvic Pain Syndrome ◽  
Male Mice ◽  
Voluntary Wheel

scholarly journals Impact of mothers’ experience and early‐life stress on aggression and cognition in adult male mice

2019 ◽  
Vol 62 (1) ◽  
pp. 36-49 ◽  
Author(s):  
Vasiliy V. Reshetnikov ◽  
Yulia A. Ryabushkina ◽  
Natalia P. Bondar
Keyword(s):  
Adult Male ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Male Mice

scholarly journals Early-Life Stress Reduces DNA Methylation of the Pomc Gene in Male Mice

Endocrinology ◽  
2014 ◽  
Vol 155 (5) ◽  
pp. 1751-1762 ◽  
Author(s):  
Yonghe Wu ◽  
Alexandre V. Patchev ◽  
Guillaume Daniel ◽  
Osborne F.X. Almeida ◽  
Dietmar Spengler
Keyword(s):  
Dna Methylation ◽  
Life Stress ◽  
Early Life ◽  
Binding Protein ◽  
Early Life Stress ◽  
Neuroendocrine Cells ◽  
Mrna Levels ◽  
Male Mice ◽  
Pomc Mrna ◽  
Pomc Gene

Early-life stress (ELS) increases the vulnerability thresholds for stress-related diseases such as major depression and anxiety by inducing alterations in the structure and function of neural circuits and endocrine pathways. We previously demonstrated the contribution of epigenetic mechanisms to the long-term programming of the hypothalamo-pituitary-adrenal axis activity following ELS exposure in male mice. Here, ELS comprising daily separation of pups from their dams on postnatal days 1–10 was observed to up-regulate the expression of the pituitary proopiomelanocortin (Pomc) gene; POMC serves as a prohormone for ACTH, a key mediator of the adrenocortical response to stress. Detailed analysis revealed that the increase in Pomc mRNA levels results from a reduction in DNA methylation at a critical regulatory region of the Pomc gene; interestingly, this change occurs with some delay after ELS and persists for up to 1 year. Using a Pomc-expressing pituitary cell line (AtT20), we confirmed a role for DNA methylation in restraining Pomc expression under resting conditions: specifically, we show that CpG site-specific methylation of the Pomc promoter represses Pomc mRNA transcription. Further, we show high-affinity binding of methyl-CpG binding protein-2 to the distal promoter of Pomc, suggesting that methyl-CpG binding protein-2 acts in association with the chromatin modifiers histone deacetylase 2 and DNA methyltransferase 1 to repress Pomc gene expression. Collectively, these experiments contribute to our understanding of the mechanisms through which environmental cues are translated into stable changes (“cellular memory”) in neuroendocrine cells.

scholarly journals The Effect of Early Life Stress on Emotional Behaviors in GPR37KO Mice

2021 ◽  
Vol 23 (1) ◽  
pp. 410
Author(s):  
Vandana Veenit ◽  
Xiaoqun Zhang ◽  
Antonio Ambrosini ◽  
Vasco Sousa ◽  
Per Svenningsson
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Emotional Processing ◽  
Early Life Stress ◽  
Plasma Corticosterone ◽  
Male Mice ◽  
Long Term Effects ◽  
Emotional Context ◽  
Nesting Material ◽  
G Protein Coupled

GPR37 is an orphan G-protein-coupled receptor, a substrate of parkin which is linked to Parkinson’s disease (PD) and affective disorders. In this study, we sought to address the effects of early life stress (ELS) by employing the paradigm of limited nesting material on emotional behaviors in adult GPR37 knockout (KO) mice. Our results showed that, while there was an adverse effect of ELS on various domains of emotional behaviors in wild type (WT) mice in a sex specific manner (anxiety in females, depression and context-dependent fear memory in males), GPR37KO mice subjected to ELS exhibited less deteriorated emotional behaviors. GPR37KO female mice under ELS conditions displayed reduced anxiety compared to WT mice. This was paralleled by lower plasma corticosterone in GPR37KO females and a lower increase in P-T286-CaMKII by ELS in the amygdala. GPR37KO male mice, under ELS conditions, showed better retention of hippocampal-dependent emotional processing in the passive avoidance behavioral task. GPR37KO male mice showed increased immobility in the forced swim task and increased P-T286-CaMKII in the ventral hippocampus under baseline conditions. Taken together, our data showed overall long-term effects of ELS—deleterious or beneficial depending on the genotype, sex of the mice and the emotional context.

scholarly journals Early life stress in male mice induces superoxide production and endothelial dysfunction in adulthood

2016 ◽  
Vol 310 (9) ◽  
pp. H1267-H1274 ◽  
Author(s):  
Dao H. Ho ◽  
Mariah L. Burch ◽  
Benjamin Musall ◽  
Jacqueline B. Musall ◽  
Kelly A. Hyndman ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cardiovascular Disease ◽  
Endothelial Dysfunction ◽  
Nadph Oxidase ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Superoxide Production ◽  
Male Mice ◽  
Oxide Synthase

Early life stress (ELS) is a risk for cardiovascular disease in adulthood although very little mechanistic insight is available. Because oxidative stress and endothelial dysfunction are major contributors to cardiovascular risk, we hypothesized that ELS induces endothelial dysfunction in adult male mice via increased superoxide production. Studies employed a mouse model of ELS, maternal separation with early weaning (MSEW), in which litters were separated from the dam for 4 h/day [ postnatal days (PD) 2–5] and 8 h/day (PD6-16), and weaned at PD17. Control litters remained undisturbed until weaning at PD21. When compared with control mice, thoracic aortic rings from adult male MSEW mice displayed significant endothelial dysfunction that was reversed by the superoxide scavenger, polyethylene glycol-superoxide dismutase (PEG-SOD). PEG-SOD-inhibitable superoxide production by aortae from MSEW mice was significantly greater than observed in control aortae, although unaffected by nitric oxide synthase inhibition, suggesting that uncoupled nitric oxide synthase was not responsible for the accelerated superoxide production. Aortic SOD expression, plasma SOD activity, and total antioxidant activity were similar in MSEW and control mice, indicating unaltered antioxidant capacity in MSEW mice. Increased expression of the NADPH oxidase subunits, NOX2 and NOX4, was evident in the aortae of MSEW mice. Moreover, endothelial dysfunction and superoxide production in MSEW mice was reversed with the NADPH oxidase inhibitor, apocynin, indicating increased NADPH oxidase-dependent superoxide production and endothelial dysfunction. The finding that MSEW induces superoxide production and endothelial dysfunction in adult mice may provide a mechanistic link between ELS and adult cardiovascular disease risk.

Early life stress disrupts peripubertal development of aggression in male mice

Neuroreport ◽  
2011 ◽  
Vol 22 (6) ◽  
pp. 259-263 ◽  
Author(s):  
Mumeko C. Tsuda ◽  
Naoko Yamaguchi ◽  
Sonoko Ogawa
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Male Mice
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