scholarly journals Role of retrosplenial cortex in processing stress-related context memories.

2018 ◽  
Vol 132 (5) ◽  
pp. 388-395 ◽  
Author(s):  
Kevin A. Corcoran ◽  
Naoki Yamawaki ◽  
Katherine Leaderbrand ◽  
Jelena Radulovic
Keyword(s):  
Retrosplenial Cortex ◽  
Processing Stress

Putting fear in context: Elucidating the role of the retrosplenial cortex in context discrimination in rats

2018 ◽  
Vol 148 ◽  
pp. 50-59 ◽  
Author(s):  
Siobhan Robinson ◽  
Julia S. Adelman ◽  
Allison S. Mogul ◽  
Peter C.J. Ihle ◽  
Gianna M. Davino
Keyword(s):  
Retrosplenial Cortex ◽  
Context Discrimination

scholarly journals Retrosplenial cortex is necessary for spatial and non-spatial latent learning in mice

2021 ◽  
Author(s):  
Ana Carolina Bottura de Barros ◽  
Liad J Baruchin ◽  
Marios C Panayi ◽  
Nils Nyberg ◽  
Veronika Samborska ◽  
...  
Keyword(s):  
Decision Making ◽  
Brain Area ◽  
Brain Structures ◽  
Internal Models ◽  
Retrosplenial Cortex ◽  
Latent Learning ◽  
Subjective Value ◽  
Spatial Decision Making ◽  
The Creation

Latent learning occurs when associations are formed between stimuli in the absence of explicit reinforcement. Traditionally, latent learning in rodents has been associated with the creation internal models of space. However, increasing evidence points to roles of internal models also in non-spatial decision making. Whether the same brain structures and processes support the creation of spatially-anchored or non-spatial internal models via latent learning, is an open question. To address this question, we developed a novel operant box task that allows to test spatial and non-spatial versions of a flavour-based sensory preconditioning paradigm. We probed the role of the retrosplenial cortex, a brain area associated with spatial cognition and subjective value representation, in this task using precise, closed-loop optogenetic silencing during different task phases. We show that the retrosplenial cortex is necessary for both spatial and non-spatial latent learning in mice. We further demonstrate that the requirement of retrosplenial cortex is limited to the preconditioning phase of the task. Our results provide insight into the specific role of the retrosplenial cortex in latent learning, demonstrate that latent learning plays a general part in the creation of internal models, independent of spatial anchors, and provide a novel avenue for studying model-based decision making.

scholarly journals Objective (Real-world) Motion Responses in Scene Responsive Regions

2017 ◽  
Author(s):  
Didem Korkmaz Hacialihafiz ◽  
Andreas Bartels
Keyword(s):  
Real World ◽  
Reference Frames ◽  
Retrosplenial Cortex ◽  
Natural Scenes ◽  
Special Role ◽  
Perceptual Stability ◽  
Retinal Motion ◽  
Motion Responses ◽  
Human Participants

AbstractWe perceive scenes as stable even when eye movements induce retinal motion, for example during pursuit of a moving object. Mechanisms mediating perceptual stability have primarily been examined in motion regions of the dorsal visual pathway. Here we examined whether motion responses in human scene regions are encoded in eye- or world centered reference frames. We recorded brain responses in human participants using fMRI while they performed a well-controlled visual pursuit paradigm previously used to examine dorsal motion regions. In addition, we examined effects of content by using either natural scenes or their Fourier scrambles. We found that parahippocampal place area (PPA) responded to motion only in world- but not in eye-centered coordinates, regardless of scene content. The occipital place area (OPA) responded to both, objective and retinal motion equally, and retrosplenial cortex (RSC) had no motion responses but responded to pursuit. Only PPA’s objective motion responses were higher during scenes than scrambled images, although there was a similar trend in OPA. These results indicate a special role of PPA in representing its content in real-world coordinates. Our results question a strict subdivision of dorsal “what” and ventral “where” streams, and suggest a role of PPA in contributing to perceptual stability.

scholarly journals Cues, context, and long-term memory: the role of the retrosplenial cortex in spatial cognition

2014 ◽  
Vol 8 ◽  
Author(s):  
Adam M. P. Miller ◽  
Lindsey C. Vedder ◽  
L. Matthew Law ◽  
David M. Smith
Keyword(s):  
Spatial Cognition ◽  
Retrosplenial Cortex ◽  
Long Term Memory ◽  
Term Memory

scholarly journals On the role of retrosplenial cortex in long-lasting memory storage

Hippocampus ◽  
2013 ◽  
Vol 23 (4) ◽  
pp. 295-302 ◽  
Author(s):  
Cynthia Katche ◽  
Guido Dorman ◽  
Carolina Gonzalez ◽  
Cecilia P. Kramar ◽  
Leandro Slipczuk ◽  
...  
Keyword(s):  
Retrosplenial Cortex ◽  
Memory Storage

Role of the human retrosplenial cortex/parieto-occipital sulcus in perspective priming

NeuroImage ◽  
2016 ◽  
Vol 125 ◽  
pp. 108-119 ◽  
Author(s):  
Valentina Sulpizio ◽  
Giorgia Committeri ◽  
Simon Lambrey ◽  
Alain Berthoz ◽  
Gaspare Galati
Keyword(s):  
Retrosplenial Cortex

scholarly journals Satb2 is required for the regionalization of retrosplenial cortex

2019 ◽  
Vol 27 (5) ◽  
pp. 1604-1617
Author(s):  
Lei Zhang ◽  
Ning-Ning Song ◽  
Qiong Zhang ◽  
Wan-Ying Mei ◽  
Chun-Hui He ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Molecular Mechanism ◽  
Cortical Development ◽  
Retrosplenial Cortex ◽  
Wild Type ◽  
Efferent Projection ◽  
Mutant Cells

Abstract The retrosplenial cortex (Rsp) is a transitional cortex located between the neocortex and archicortex, but the molecular mechanism specifying Rsp from the archicortex remains elusive. We here report that the transcription factor Satb2 is required for specifying Rsp identity during its morphogenesis. In Satb2 CKO mice, the boundary between the Rsp and archicortex [i.e., subiculum (SubC)] disappears as early as E17.5, and Rsp efferent projection is aberrant. Rsp-specific genes are lost, whereas SubC-specific genes are ectopically expressed in Rsp of Satb2 CKO mice. Furthermore, cell-autonomous role of Satb2 in maintaining Rsp neuron identity is revealed by inactivation of Satb2 in Rsp neurons. Finally, Satb2 represses the transcription of Nr4a2. The misexpression of Nr4a2 together with Ctip2 induces expression of SubC-specific genes in wild-type Rsp, and simultaneous knockdown of these two genes in Rsp Satb2-mutant cells prevents their fate transition to SubC identity. Thus, Satb2 serves as a determinant gene in the Rsp regionalization by repressing Nr4a2 and Ctip2 during cortical development.

scholarly journals Precuneus stimulation alters the neural dynamics of autobiographical memory retrieval

2019 ◽  
Author(s):  
Melissa Hebscher ◽  
Christine Ibrahim ◽  
Asaf Gilboa
Keyword(s):  
Autobiographical Memory ◽  
Memory Retrieval ◽  
Temporal Dynamics ◽  
Retrosplenial Cortex ◽  
Neural Representation ◽  
Causal Role ◽  
Late Positive Component ◽  
Spatial Perspective ◽  
Early Memory

AbstractAutobiographical memory (AM) unfolds over time, but little is known about the dynamics of its retrieval. Space-based models of memory implicate the hippocampus, retrosplenial cortex, and precuneus in early memory computations. Here we used inhibitory continuous theta burst stimulation (cTBS) to determine the causal role of the precuneus in the temporal dynamics of AM retrieval. Compared to vertex, precuneus stimulation altered evoked neural activity during early memory construction, as early as 400 ms after cue presentation, as well as during later memory elaboration. We further identified a parietal late positive component during memory elaboration, the amplitude of which was associated with spatial perspective during recollection. Precuneus stimulation disrupted this association, suggesting that this region plays a crucial role in the neural representation of spatial perspective during AM. These findings help clarify the neural correlates of early memory retrieval and demonstrate a causal role for the precuneus in the temporal dynamics of AM retrieval.

scholarly journals Neonatal ethanol exposure triggers apoptosis in the murine retrosplenial cortex: Role of inhibition of NMDA receptor-driven action potential firing

2020 ◽  
Vol 162 ◽  
pp. 107837 ◽  
Author(s):  
Clark W. Bird ◽  
Megan J. Barber ◽  
Hilary R. Post ◽  
Belkis Jacquez ◽  
Glenna J. Chavez ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Action Potential ◽  
Ethanol Exposure ◽  
Retrosplenial Cortex ◽  
Action Potential Firing ◽  
Potential Firing

scholarly journals Cortical Contributions to Higher-Order Conditioning: A Review of Retrosplenial Cortex Function

2021 ◽  
Vol 15 ◽  
Author(s):  
Danielle I. Fournier ◽  
Han Yin Cheng ◽  
Siobhan Robinson ◽  
Travis P. Todd
Keyword(s):  
Brain Structures ◽  
Neutral Stimulus ◽  
Higher Order ◽  
Retrosplenial Cortex ◽  
Second Order ◽  
Future Research ◽  
Cortical Region ◽  
Sensory Preconditioning ◽  
Order Conditioning

In higher-order conditioning paradigms, such as sensory preconditioning or second-order conditioning, discrete (e.g., phasic) or contextual (e.g., static) stimuli can gain the ability to elicit learned responses despite never being directly paired with reinforcement. The purpose of this mini-review is to examine the neuroanatomical basis of high-order conditioning, by selectively reviewing research that has examined the role of the retrosplenial cortex (RSC) in sensory preconditioning and second-order conditioning. For both forms of higher-order conditioning, we first discuss the types of associations that may occur and then review findings from RSC lesion/inactivation experiments. These experiments demonstrate a role for the RSC in sensory preconditioning, suggesting that this cortical region might contribute to higher-order conditioning via the encoding of neutral stimulus-stimulus associations. In addition, we address knowledge gaps, avenues for future research, and consider the contribution of the RSC to higher-order conditioning in relation to related brain structures.

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