scholarly journals A prenatal programming perspective on the intergenerational transmission of maternal adverse childhood experiences to offspring health problems.

2021 ◽  
Vol 76 (2) ◽  
pp. 337-349
Author(s):  
Danielle S. Roubinov ◽  
Linda J. Luecken ◽  
Sarah G. Curci ◽  
Jennifer A. Somers ◽  
Laura K. Winstone
2021 ◽  
pp. 155982762110012
Author(s):  
Garry Egger ◽  
Andrew Binns ◽  
Bob Morgan ◽  
John Stevens

We have previously proposed a list of determinants (causes) of modern lifestyle-related chronic disorders, which provides a structure for the emerging discipline of lifestyle medicine. This consists of lifestyle factors with a common immune biomarker ( metaflammation) that interact in a systems fashion linked with chronic disease outcomes. We considered this to be a work in progress and later added 3 psychosocial determinants into the causal mix: meaninglessness, alienation, and loss of culture and identity (MAL). Here, we propose adverse childhood experiences (ACEs) as deeper, or even more distal, disease drivers that may act directly or indirectly through MAL to influence later chronic disease. The links with metaflammation and the need for recognition of these embedded scars in the management of lifestyle-related health problems is discussed.


PEDIATRICS ◽  
2018 ◽  
Vol 142 (2) ◽  
pp. e20180023 ◽  
Author(s):  
Adam Schickedanz ◽  
Neal Halfon ◽  
Narayan Sastry ◽  
Paul J. Chung

2003 ◽  
Vol 37 (3) ◽  
pp. 268-277 ◽  
Author(s):  
Shanta R Dube ◽  
Vincent J Felitti ◽  
Maxia Dong ◽  
Wayne H Giles ◽  
Robert F Anda

2021 ◽  
pp. 154120402110036
Author(s):  
Jessica M. Craig ◽  
Catia Malvaso ◽  
David P. Farrington

Research indicates that individuals with Adverse Childhood Experiences (ACEs) are more likely to offend, and that some ACEs, such as offending and child maltreatment, are transmitted from one generation to the next. However, the extent to which ACEs are transferred across generations and its subsequent impact on offending has not been examined. Using data from the Cambridge Study in Delinquent Development, this study examined the intergenerational transmission of ACEs and the extent to which this was associated with offending in the second generation. Although parental ACEs increased the likelihood of the subsequent generation’s ACEs, other risk factors attenuated this effect. Additionally, ACEs’ impact on the second generation’s convictions was also weakened after controlling for other risk factors. This provides evidence of intergenerational transmission of ACEs and additionally the effects of ACEs on the risk of offending. However, these associations are not straightforward and other risk factors likely play an important role in elucidating these relationships.


2021 ◽  
Author(s):  
Ruth Brown ◽  
Manuel Eisner ◽  
Susan Walker ◽  
Mark Tomlinson ◽  
Pasco Fearon ◽  
...  

Mothers from middle-income countries (MIC) are estimated to have higher rates of adverse childhood experiences (ACEs) and depression during pregnancy compared to mothers from high income countries. Prenatal depression can adversely impact on a mother's feelings towards her foetus and has thus been hypothesised to be partially responsible for intergenerational transmission of risk associated with maternal ACEs. However, the extent to which prenatal depressive symptoms mediate the association between maternal ACEs and foetal attachment is unknown. The current study investigated this question in a multi-country sample of mothers in their third trimester of pregnancy. Expectant mothers (n = 1,185) from eight MICs completed measures of foetal attachment, ACEs and prenatal depression. Full-sample path mediation analyses, adjusting for relevant covariates, suggested an overall full mediating effect of prenatal depression, as the relationship between ACEs and foetal attachment became non-significant when adding maternal depression as a mediator. However, at the individual-country level, both positive and negative effects of ACEs on foetal attachment were observed after the inclusion of depressive symptoms as a mediator, suggesting that cultural and geographical factors may influence a mother’s empathic development after ACE exposure. The findings reinforce the importance of screening for prenatal depression during antenatal care in MICs. Addressing prenatal depression within maternal health care may support foetal attachment and contribute to reducing the intergenerational transmission of disadvantage.


Sign in / Sign up

Export Citation Format

Share Document