scholarly journals I’m tired and feel like drinking: Viewing alcohol cues after exerting self-control increases approach motivation among individuals lower in alcohol sensitivity.

2019 ◽  
Vol 33 (7) ◽  
pp. 626-636
Author(s):  
Zachary W. Petzel ◽  
Jeffrey G. Noel ◽  
Bettina J. Casad
2014 ◽  
Vol 5 ◽  
Author(s):  
Adrienne Crowell ◽  
Nicholas J. Kelley ◽  
Brandon J. Schmeichel

2011 ◽  
Vol 42 (3) ◽  
pp. 776-792 ◽  
Author(s):  
HANNEKE A. TEUNISSEN ◽  
RENSKE SPIJKERMAN ◽  
TIM M. SCHOENMAKERS ◽  
KATHLEEN D. VOHS ◽  
RUTGER C. M. E. ENGELS

Biomolecules ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1183
Author(s):  
Yi-Chyan Chen ◽  
Li-Fang Yang ◽  
Ching-Long Lai ◽  
Shih-Jiun Yin

Alcoholism is a complex behavior trait influenced by multiple genes as well as by sociocultural factors. Alcohol metabolism is one of the biological determinants that can significantly influence drinking behaviors. Alcohol sensitivity is thought to be a behavioral trait marker for susceptibility to develop alcoholism. The subjective perceptions would be an indicator for the alcohol preference. To investigate alcohol sensitivity for the variants ADH1B*2 and ALDH2*2, sixty healthy young males with different combinatory ADH1B and ALDH2 genotypes, ADH1B*2/*2–ALDH2*1/*1 (n = 23), ADH1B*2/*2–ALDH2*1/*2 (n = 27), and ADH1B*1/*1–ALDH2*1/*1 (n = 10), participated in the study. The subjective perceptions were assessed by a structured scale, and blood ethanol and acetaldehyde were determined by GC and HPLC after an alcohol challenge in two dose sessions (0.3 g/kg or 0.5 g/kg ethanol). The principal findings are (1) dose-dependent increase of blood ethanol concentration, unaffected by ADH1B or ALDH2; (2) significant build-up of blood acetaldehyde, strikingly influenced by the ALDH2*2 gene allele and correlated with the dose of ingested alcohol; (3) the increased heart rate and subjective sensations caused by acetaldehyde accumulation in the ALDH2*2 heterozygotes; (4) no significant effect of ADH1B polymorphism in alcohol metabolism or producing the psychological responses. The study findings provide the evidence of acetaldehyde potentiating the alcohol sensitivity and feedback to self-control the drinking amount. The results indicate that ALDH2*2 plays a major role for acetaldehyde-related physiological negative responses and prove the genetic protection against development of alcoholism in East Asians.


2020 ◽  
Author(s):  
◽  
Jorge S. Martins

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Background and Significance. Decades of research have consistently suggested that persistent problematic drinking is an etiologically heterogeneous condition. This heterogeneity has been proposed as an explanation for why current general prevention and intervention efforts are still largely ineffective. Therefore, understanding this existing heterogeneity seems crucial for developing more effective prevention and intervention efforts aimed at reducing harmful and hazardous drinking. Specific Aims. The current study aimed to (Aim 1) determine the unique and specific effects of seven functional domains (Incentive Salience/Craving, Alcohol Sensitivity, Negative Emotionality, Alcohol Withdrawal, Executive Functions, Risk Propensity, and Self-Control/Disinhibition) on alcohol use and related experiences, including harmful and hazardous drinking; (Aim 2) determine the classification utility of varying combinations of functional domains in discriminating individuals at risk for harmful and hazardous drinking; (Aim 3) identify common profiles of the hypothesized functional domains that may either protect or place individuals at higher risk and explore their group-specific etiological relevance for harmful and hazardous drinking; (Aim 4) identify the most "central" or influential domains for the emergence, development, and maintenance of persistent harmful and hazardous drinking. Methods. The current study included data from 552 emerging and young adults, who completed an assessment battery consisting of self-report and behavioral task measures that provided demographic and personal history information, alcohol use and related experiences, and estimates of core neurocognitive abilities pertaining to the hypothesized functional domains. Results. Results indicated that the functional domains were differentially associated with measures of alcohol use and related experiences and failed to consistently show robust associations with all alcohol-related measures, when tested simultaneously. Nevertheless, Incentive Salience/Craving, Alcohol Sensitivity, Alcohol Withdrawal, and Self-Control/Disinhibition showed expected unique associations with most drinking measures, whereas Negative Emotionality showed a handful of unexpected negative associations. Results also indicated that the combination of Incentive Salience/Craving, Alcohol Withdrawal, and Alcohol Sensitivity produced the single most parsimonious and optimal combination with the best classification utility in discriminating individuals at risk for harmful and hazardous drinking. Furthermore, even though Alcohol Withdrawal and Alcohol Sensitivity produced an acceptable classification precision, Incentive Salience/Craving demonstrated by far the strongest predictive utility and diagnostic value. Results from mixture modeling identified three homogeneous and well-separated classes characterized by distinct underlying risk profiles of neurocognitive abilities pertaining to the functional domains, as well as unique patterns of alcohol use and related experiences: Low Risk/Light Drinkers-Abstainers (n = 116, 21 [percent]); Moderate Risk/Social Drinkers (n = 231, 42 [percent]); and High Risk/Problem Drinkers (n = 205, 37 [percent]). Finally, Self-Control/Disinhibition was consistently identified as the most interconnected and highly central domain, whereas Alcohol Sensitivity was weakly interconnected in all class-specific network configurations. No significant differences were found in either local or global connectivity of the class-specific network architectures. Conclusion. Taken all together, the current results contribute to enhance our understanding of the relative importance of etiologically relevant alcohol-specific and transdiagnostic domains for persistent problematic drinking. Theoretical insights for understanding of the etiological heterogeneity of harmful and hazardous drinking, as well as practical implications for personalized prevention of persistent problematic drinking are discussed.


2010 ◽  
Vol 99 (1) ◽  
pp. 162-173 ◽  
Author(s):  
Brandon J. Schmeichel ◽  
Cindy Harmon-Jones ◽  
Eddie Harmon-Jones

2007 ◽  
Vol 21 (4) ◽  
pp. 555-563 ◽  
Author(s):  
Bruce D. Bartholow ◽  
Erika A. Henry ◽  
Sarah A. Lust

2016 ◽  
Vol 30 (6) ◽  
pp. 846-853
Author(s):  
Tracy Cheung ◽  
Marleen Gillebaart ◽  
Floor Kroese ◽  
Denise de Ridder

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