scholarly journals Effects of long-term AA attendance and spirituality on the course of depressive symptoms in individuals with alcohol use disorder.

2015 ◽  
Vol 29 (2) ◽  
pp. 382-391 ◽  
Author(s):  
Claire E. Wilcox ◽  
Matthew R. Pearson ◽  
J. Scott Tonigan
Keyword(s):  
Depressive Symptoms ◽  
Alcohol Use ◽  
Alcohol Use Disorder

Residual alcohol use disorder symptoms after treatment predict long‐term drinking outcomes in seniors with DSM‐5 alcohol use disorder

2021 ◽  
Author(s):  
Silke Behrendt ◽  
Alexis Kuerbis ◽  
Barbara Braun‐Michl ◽  
Randi Bilberg ◽  
Gerhard Bühringer ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Dsm 5 ◽  
Drinking Outcomes

scholarly journals Stability of Drinking Reductions and Long-term Functioning Among Patients with Alcohol Use Disorder

2020 ◽  
Author(s):  
Katie Witkiewitz ◽  
Henry R. Kranzler ◽  
Kevin A. Hallgren ◽  
Deborah S. Hasin ◽  
Arnie P. Aldridge ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Well Being ◽  
Total Sample ◽  
World Health ◽  
End Of Treatment

Abstract Background The World Health Organization (WHO) categorizes alcohol consumption according to grams consumed into low-, medium-, high-, and very-high-risk drinking levels (RDLs). Although abstinence has been considered the ideal outcome of alcohol treatment, reductions in WHO RDLs have been proposed as primary outcomes for alcohol use disorder (AUD) trials. Objective The current study examines the stability of WHO RDL reductions and the association between RDL reductions and long-term functioning for up to 3 years following treatment. Design and Participants Secondary data analysis of patients with AUD enrolled in the COMBINE Study and Project MATCH, two multi-site, randomized AUD clinical trials, who were followed for up to 3 years post-treatment (COMBINE: n = 694; MATCH: n = 806). Measures Alcohol use was measured via calendar-based methods. We estimated all models in the total sample and among participants who did not achieve abstinence during treatment. Key Results One-level RDL reductions were achieved by 84% of patients at the end of treatment, with 84.9% of those individuals maintaining that reduction at a 3-year follow-up. Two-level RDL reductions were achieved by 68% of patients at the end of treatment, with 77.7% of those individuals maintaining that reduction at a 3-year follow-up. One- and two-level RDL reductions at the end of treatment were associated with significantly better mental health, quality of life (including physical quality of life), and fewer drinking consequences 3 years after treatment (p < 0.05), as compared to no change or increased drinking. Conclusion AUD patients can maintain WHO RDL reductions for up to 3 years after treatment. Patients who had WHO RDL reductions functioned significantly better than those who did not reduce their drinking. These findings are consistent with prior reports suggesting that drinking reductions, short of abstinence, yield meaningful improvements in patient health, well-being, and functioning.

Clinical Outcomes of the First 2 Years of Implementation of the Integrated Care Pathway for Concurrent Major Depressive Disorder and Alcohol Use Disorder

2017 ◽  
Vol 41 (S1) ◽  
pp. S79-S79 ◽  
Author(s):  
A.V. Samokhvalov ◽  
S. Awan ◽  
B. Le Foll ◽  
C. Probst ◽  
P. Voore ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Symptoms ◽  
Alcohol Use ◽  
Depressive Disorder ◽  
Integrated Care ◽  
Alcohol Use Disorder ◽  
Care Pathway ◽  
Retention Rates ◽  
Major Depressive ◽  
Integrated Care Pathway

BackgroundBoth major depressive disorder (MDD) and alcohol use disorder are highly prevalent, often comorbid and cause significant socioeconomic burden. At CAMH, we have developed and integrated care pathway (ICP) to treat these disorders and evaluated its effectiveness in comparison to treatment as usual (TAU)MethodsChart review; descriptive statistics, c2 and t-tests, linear mixed effects models, Kaplan–Meier and log-rank analyses.ResultsOverall, 81 patients were enrolled into ICP. Comparisons of treatment retention rates between ICP patients and matched historical controls (n = 81) showed significantly lower dropout rate in ICP cohort (18.5% vs. 69.1%, P < 0.001, Fig. 1). The ICP patients demonstrated significant reduction in depressive symptoms severity (QIDS: 14.6 vs. 10.0, P < 0.001; BDI 26.3 vs. 16.2, P < 0.001), reduction in the amount of alcohol consumed weekly from 44.6 standard drinks at baseline to 12.6 (P < 0.001) by the end of treatment, which was significantly better compared to controls (56.9 vs. 25.2, P < 0.001), P = 0.014 (Fig. 2).ConclusionsThe ICP is a feasible approach to treatment of concurrent AUD and MDD with significantly higher retention rates than TAU. Patients demonstrate improvements on several levels including depressive symptoms, and changes in alcohol drinking patterns.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Mechanisms of Alcohol Use Disorder Severity in Adolescents with Co-occurring Depressive Symptoms: Findings from a School-Based Substance Use Intervention

2014 ◽  
Vol 7 (2) ◽  
pp. 147-159 ◽  
Author(s):  
David G. Stewart ◽  
Virginia K. Arlt ◽  
Benjamin Felleman ◽  
Dylan R. Athenour ◽  
Christopher Arger
Keyword(s):  
Substance Use ◽  
Depressive Symptoms ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
School Based

scholarly journals Evaluation of Guanfacine as a Potential Medication for Alcohol Use Disorder in Long-Term Drinking Rats: Behavioral and Electrophysiological Findings

2014 ◽  
Vol 40 (5) ◽  
pp. 1130-1140 ◽  
Author(s):  
Ida Fredriksson ◽  
Nitya Jayaram-Lindström ◽  
Malin Wirf ◽  
Erik Nylander ◽  
Erica Nyström ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Electrophysiological Findings

The Impact of Comorbid Conditions on Long-Term Patient-Reported Outcomes From Burn Survivors

2020 ◽  
Vol 41 (5) ◽  
pp. 956-962
Author(s):  
Clifford C Sheckter ◽  
Kevin Li ◽  
Gretchen J Carrougher ◽  
Tam N Pham ◽  
Nicole S Gibran ◽  
...  
Keyword(s):  
Mental Illness ◽  
Alcohol Use ◽  
Mental Component Summary ◽  
Patient Reported Outcomes ◽  
Alcohol Use Disorder ◽  
Negatively Associated ◽  
Risk Of Death ◽  
Patient Reported ◽  
The Impact

Abstract Preburn comorbidities increase the risk of death in the acute phase, and negatively impact quality of life among survivors. Investigations to date have only evaluated comorbidities as indices, limiting the ability to target conditions and develop strategies for risk reduction. Therefore, we aimed to evaluate the differential effects of specific conditions on long-term, patient-reported outcomes after burn injury. A prospectively maintained trauma registry was merged with a longitudinal database of patient-reported outcomes from a regional burn center from 2007 to 2018. Demographic data, injury-specific information, and the prevalence of 20 comorbidities were systematically documented. The impact of comorbidities on responses to Short Form-12/Veterans RAND 12 (SF/VR-12) health surveys at 6, 12, and 24 months postinjury was evaluated with generalized linear models. The merged dataset included 493 adult participants. Median age was 46 years (interquartile range, IQR 32–57 years), and 72% were male. Median burn size was 14% TBSA (IQR 5–28%). Seventy percent of participants had ≥1 comorbidity (median 1 comorbidity/participant; IQR 0–2 comorbidities). SF/VR-12 mental component summary scores at 6 and 12 months postinjury were negatively associated with mental illness (P &lt; .001, P = .013). SF/VR-12 physical component summary (PCS) scores were negatively associated with smoking (P = .019), diabetes (P = .001), and alcohol use disorder (P = .001) at 6-month follow-up. Twelve-month SF/VR-12 PCS scores were negatively associated with prior trauma admission (P = .001) and diabetes (P = .042). Twenty-four-month SF/VR-12 PCS scores were negatively associated with mental illness (P = .003). Smoking, alcohol use disorder, and diabetes were associated with lower PCS scores 6 months after injury; diabetes persisted as a negatively associated covariate at 12 months. Mental component summary scores were negatively associated with mental illness 6 and 12 months postinjury. Integrated models of postdischarge comorbidity management need to be tested in burn patients.

scholarly journals Do Alcohol Relapse Episodes During Treatment Predict Long-Term Outcomes? Investigating the Validity of Existing Definitions of Alcohol Use Disorder Relapse

2016 ◽  
Vol 40 (10) ◽  
pp. 2180-2189 ◽  
Author(s):  
Stephen A. Maisto ◽  
Corey R. Roos ◽  
Kevin A. Hallgren ◽  
Dezarie Moskal ◽  
Adam D. Wilson ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Long Term Outcomes ◽  
Alcohol Relapse

scholarly journals Long Term Pharmacotherapy for Alcohol Use Disorder

2020 ◽  
pp. 1-12
Author(s):  
Indranil Saha ◽  
Supartha Barua ◽  
Arijit Mondal
Keyword(s):  
Cost Effectiveness ◽  
Alcohol Use ◽  
Alcohol Dependence ◽  
Alcohol Use Disorder ◽  
Chronic Alcoholism ◽  
Psychosocial Treatment ◽  
Pharmacological Management ◽  
Meta Analyses ◽  
Drug Studies

The psychopharmacology of alcohol dependence is today poised at interesting crossroads. Three major drugs Naltrexone, Disulfiram and Acamprosate have been tried and tested in various trials and have many meta-analyses each to support them. While Naltrexone may reduce craving, Acamprosate scores on cost effectiveness worldwide with Disulfiram being an alcohol deterrent drug. Studies support, refute and criticize the use of each of these drugs. Combining one or more of them is also a trend seen. The most important factor in efficacy has been the combination of psychosocial treatment with medication. In this article, we are going to discuss about long term pharmacological management of chronic alcoholism.

Sign in / Sign up

Export Citation Format

Share Document