scholarly journals Nicotine deprivation increases pain intensity, neurogenic inflammation, and mechanical hyperalgesia among daily tobacco smokers.

2018 ◽  
Vol 127 (6) ◽  
pp. 578-589 ◽  
Author(s):  
Joseph W. Ditre ◽  
Emily L. Zale ◽  
Lisa R. LaRowe ◽  
Jesse D. Kosiba ◽  
Martin J. De Vita
Keyword(s):  
Pain Intensity ◽  
Neurogenic Inflammation ◽  
Mechanical Hyperalgesia ◽  
Nicotine Deprivation

(186) Mechanical hyperalgesia predicts clinical pain intensity of patients with rheumatoid arthritis or fibromyalgia

2014 ◽  
Vol 15 (4) ◽  
pp. S22
Author(s):  
R. Staud ◽  
D. Grossman ◽  
H. Guelfi ◽  
V. DeLelys ◽  
T. Amilineni ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Pain Intensity ◽  
Mechanical Hyperalgesia ◽  
Clinical Pain

scholarly journals Effects of nicotine deprivation on current pain intensity among daily cigarette smokers.

2018 ◽  
Vol 26 (5) ◽  
pp. 448-455 ◽  
Author(s):  
Lisa R. LaRowe ◽  
Jesse D. Kosiba ◽  
Emily L. Zale ◽  
Joseph W. Ditre
Keyword(s):  
Pain Intensity ◽  
Cigarette Smokers ◽  
Nicotine Deprivation

scholarly journals Psychosocial factors partially mediate the relationship between mechanical hyperalgesia and self-reported pain

2018 ◽  
Vol 18 (1) ◽  
pp. 59-69 ◽  
Author(s):  
Kayleigh J. Mason ◽  
Terence W. O’Neill ◽  
Mark Lunt ◽  
Anthony K.P. Jones ◽  
John McBeth
Keyword(s):  
Pain Intensity ◽  
Psychosocial Factors ◽  
Knee Pain ◽  
Illness Perceptions ◽  
Tender Point ◽  
Mechanical Hyperalgesia ◽  
Point Count ◽  
Central Processing ◽  
Global Pain ◽  
Painful Knee

Abstract Background and aims: Amplification of sensory signalling within the nervous system along with psychosocial factors contributes to the variation and severity of knee pain. Quantitative sensory testing (QST) is a non-invasive test battery that assesses sensory perception of thermal, pressure, mechanical and vibration stimuli used in the assessment of pain. Psychosocial factors also have an important role in explaining the occurrence of pain. The aim was to determine whether QST measures were associated with self-reported pain, and whether those associations were mediated by psychosocial factors. Methods: Participants with knee pain identified from a population-based cohort completed a tender point count and a reduced QST battery of thermal, mechanical and pressure pain thresholds, temporal summation, mechanical pain sensitivity (MPS), dynamic mechanical allodynia (DMA) and vibration detection threshold performed following the protocol by the German Research Network on Neuropathic Pain. QST assessments were performed at the most painful knee and opposite forearm (if pain-free). Participants were asked to score for their global and knee pain intensities within the past month (range 0–10), and complete questionnaire items investigating anxiety, depression, illness perceptions, pain catastrophising, and physical functioning. QST measures (independent variable) significantly correlated (Spearman’s rho) with self-reported pain intensity (dependent variable) were included in structural equation models with psychosocial factors (latent mediators). Results: Seventy-two participants were recruited with 61 participants (36 women; median age 64 years) with complete data included in subsequent analyses. Tender point count was significantly correlated with global pain intensity. DMA at the knee and MPS at the most painful knee and opposite pain-free forearm were significantly correlated with both global pain and knee pain intensities. Psychosocial factors including pain catastrophising sub-scales (rumination and helplessness) and illness perceptions (consequences and concern) were significant partial mediators of the association with global pain intensity when loaded on to a latent mediator for: tender point count [75% total effect; 95% confidence interval (CI) 22%, 100%]; MPS at the knee (49%; 12%, 86%); and DMA at the knee (63%; 5%, 100%). Latent psychosocial factors were also significant partial mediators of the association between pain intensity at the tested knee with MPS at the knee (30%; 2%, 58%), but not for DMA at the knee. Conclusions: Measures of mechanical hyperalgesia at the most painful knee and pain-free opposite forearm were associated with increased knee and global pain indicative of altered central processing. Psychosocial factors were significant partial mediators, highlighting the importance of the central integration of emotional processing in pain perception. Implications: Associations between mechanical hyperalgesia at the forearm and knee, psychosocial factors and increased levels of clinical global and knee pain intensity provide evidence of altered central processing as a key mechanism in knee pain, with psychological factors playing a key role in the expression of clinical pain.

scholarly journals Comparison of Dry Needling versus Orthopedic Manual Therapy in Patients with Myofascial Chronic Neck Pain: A Single-Blind, Randomized Pilot Study

2015 ◽  
Vol 2015 ◽  
pp. 1-15 ◽  
Author(s):  
Irene Campa-Moran ◽  
Etelvina Rey-Gudin ◽  
Josué Fernández-Carnero ◽  
Alba Paris-Alemany ◽  
Alfonso Gil-Martinez ◽  
...  
Keyword(s):  
Neck Pain ◽  
Pain Intensity ◽  
Manual Therapy ◽  
Pain Catastrophizing ◽  
Chronic Neck Pain ◽  
Mechanical Hyperalgesia ◽  
Time Interval ◽  
Dry Needling ◽  
Neck Disability ◽  
Side Bending

Objective. The aim of this study was to compare the efficacy of three interventions for the treatment of myofascial chronic neck pain. Methods. Thirty-six patients were randomly assigned to one of three intervention groups: orthopedic manual therapy (OMT), dry needling and stretching (DN-S), and soft tissue techniques (STT). All groups received two treatment sessions with a 48 h time interval. Outcome measures included neck pain intensity measured using a visual analogue scale, cervical range of motion (ROM), pressure pain threshold for measuring mechanical hyperalgesia, and two self-reported questionnaires (neck disability index and pain catastrophizing scale). Results. The ANOVA revealed significant differences for the group × time interaction for neck disability, neck pain intensity, and pain catastrophizing. The DN-S and OMT groups reduced neck disability. Only the OMT group showed decreases in mechanical hyperalgesia and pain catastrophizing. The cervical ROM increased in OMT (i.e., flexion, side-bending, and rotation) and DN-S (i.e., side-bending and rotation) groups. Conclusions. The three interventions are all effective in reducing pain intensity. Reduction in mechanical hyperalgesia and pain catastrophizing was only observed in the OMT group. Cervical ROM improved in the DN-S and OMT groups and also neck disability being only clinically relevant for OMT group.

Ineffectiveness of Neurokinin-1 Antagonist in Acute Migraine

Cephalalgia ◽  
1997 ◽  
Vol 17 (7) ◽  
pp. 785-790 ◽  
Author(s):  
DJ Goldstein ◽  
O Wang ◽  
JR Saper ◽  
R Stoltz ◽  
SD Silberstein ◽  
...  
Keyword(s):  
Pain Intensity ◽  
Neurogenic Inflammation ◽  
Study Drug ◽  
Acute Migraine ◽  
Double Blind ◽  
Migraine Headaches ◽  
Migraine Pain ◽  
Significant Difference ◽  
Associated Symptoms ◽  
Neurokinin 1

Lanepitant is a high-affinity selective neurokinin-1 receptor (NK-1) and is effective in the dural inflammation model of acute migraine. Lanepitant 30, 80, and 240 mg given orally was evaluated in a double-blind, placebo-controlled crossover study to determine its effect in reducing migraine pain and severity of associated symptoms. Outpatients treated four migraine headaches of moderate or severe pain intensity with study drug according to a randomization schedule. They recorded their pain intensity and severity of migraine-associated symptoms at 30, 60, 90, and 120 min. Although 53 patients were randomly allocated to a treatment sequence, only 40 patients, completed all treatments. There was no statistically significant difference in improvement in migraine pain at any time for any of the treatments. Additionally, there was no change in severity of migraine associated symptoms associated with lanepitant therapy. No adverse events could be attributed to lanepitant Lanepitant was ineffective orally in treating acute migraine in this trial. This may be due to poor bioavailability during a migraine attack. Alternatively, the neurogenic inflammation hypothesis may not apply to migraine.

Fear of pain and pain intensity: Meta-analysis and systematic review.

2020 ◽  
Vol 146 (5) ◽  
pp. 411-450 ◽  
Author(s):  
Tobias Markfelder ◽  
Paul Pauli
Keyword(s):  
Systematic Review ◽  
Pain Intensity ◽  
Meta Analysis ◽  
Fear Of Pain
Sign in / Sign up

Export Citation Format

Share Document