scholarly journals HPA axis multilocus genetic profile score moderates the impact of interpersonal stress on prospective increases in depressive symptoms for offspring of depressed mothers.

2017 ◽  
Vol 126 (8) ◽  
pp. 1017-1028 ◽  
Author(s):  
Cope Feurer ◽  
John E. McGeary ◽  
Valerie S. Knopik ◽  
Leslie A. Brick ◽  
Rohan H. Palmer ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Hpa Axis ◽  
Genetic Profile ◽  
Interpersonal Stress ◽  
Profile Score ◽  
Depressed Mothers ◽  
The Impact

Interpersonal childhood adversity and stress generation in adolescence: Moderation by HPA axis multilocus genetic variation

2019 ◽  
Vol 32 (3) ◽  
pp. 865-878 ◽  
Author(s):  
Meghan Huang ◽  
Lisa R. Starr
Keyword(s):  
Genetic Variation ◽  
Hpa Axis ◽  
Childhood Adversity ◽  
Stress Generation ◽  
Genetic Profile ◽  
Environment Interaction ◽  
Interpersonal Stress ◽  
Nucleotide Polymorphisms ◽  
Wide Range ◽  
Profile Score

AbstractResearch suggests that childhood adversity (CA) is associated with a wide range of repercussions, including an increased likelihood of interpersonal stress generation. This may be particularly true following interpersonal childhood adversity (ICA) and for youth with high hypothalamic-pituitary-adrenal (HPA) axis-related genetic risk. In the current study, we applied a multilocus genetic profile score (MGPS) approach to measuring HPA axis-related genetic variation and examined its interaction with ICA to predict interpersonal stress generation in a sample of adolescents aged 14–17 (N = 241, Caucasian subsample n = 192). MGPSs were computed using 10 single nucleotide polymorphisms from HPA axis-related genes (CRHR1, NRC31, NRC32, and FKBP5). ICA significantly predicted greater adolescent interpersonal dependent stress. Additionally, MGPS predicted a stronger association between ICA and interpersonal dependent (but not independent or noninterpersonal dependent) stress. No gene–environment interaction (G×E) effects were found for noninterpersonal CA and MGPS in predicting adolescent interpersonal dependent stress. Effects remained after controlling for current depressive symptoms and following stratification by race. Findings extend existing G×E research on stress generation to HPA axis-related genetic variation and demonstrate effects specific to the interpersonal domain.

scholarly journals HPA-axis multilocus genetic profile score moderates the association between maternal prenatal perceived stress and offspring depression in early adulthood

2020 ◽  
pp. 1-13 ◽  
Author(s):  
Brooke G. McKenna ◽  
Constance Hammen ◽  
Patricia A. Brennan
Keyword(s):  
Perceived Stress ◽  
Hpa Axis ◽  
Fetal Programming ◽  
Genetic Risk ◽  
Maternal Stress ◽  
Early Adulthood ◽  
Genetic Profile ◽  
Polygenic Risk ◽  
Profile Score ◽  
Prospective Longitudinal

Abstract Maternal stress during pregnancy can cause alterations to the fetal hypothalamus–pituitary–adrenal (HPA) axis, a phenomenon known as fetal programming that may have lasting effects on offspring outcomes, including depression. Evidence suggests that these effects may vary with respect to the offspring's genetic risk. Nonetheless, few studies have examined these effects into adulthood, when risk for depression onset is highest. The present study builds upon the extant literature by examining the interaction of maternal prenatal perceived stress (MPPS) and offspring HPA-axis polygenic risk to predict offspring depression in early adulthood. A total of 381 mother–child dyads participated in a prospective, longitudinal study that spanned from pregnancy until offspring were 20 years of age. Polygenic risk was defined by a multilocus genetic profile score (MGPS) that reflected the additive risk of three HPA-axis candidate genes. The results indicated that the interaction of MPPS and HPA-axis MGPS confers risk for offspring depression at age 20, in line with the differential susceptibility model. This interaction may be specific to prenatal stress, as maternal stress during early childhood did not interact with genetic risk to predict depression. These findings provide the first evidence that genetic variants that are associated with the HPA axis may act in a polygenic, additive fashion to moderate the association between fetal programming and adult depression.

scholarly journals Interpersonal Stress Severity Longitudinally Predicts Adolescent Girls’ Depressive Symptoms: the Moderating Role of Subjective and HPA Axis Stress Responses

2018 ◽  
Vol 47 (5) ◽  
pp. 895-905 ◽  
Author(s):  
Sarah A. Owens ◽  
Sarah W. Helms ◽  
Karen D. Rudolph ◽  
Paul D. Hastings ◽  
Matthew K. Nock ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Adolescent Girls ◽  
Hpa Axis ◽  
Stress Responses ◽  
Interpersonal Stress ◽  
Moderating Role

HPA-axis multilocus genetic variation moderates associations between environmental stress and depressive symptoms among adolescents

2018 ◽  
Vol 31 (04) ◽  
pp. 1339-1352 ◽  
Author(s):  
Lisa R. Starr ◽  
Meghan Huang
Keyword(s):  
Genetic Variation ◽  
Depressive Symptoms ◽  
Chronic Stress ◽  
Hpa Axis ◽  
Acute Stress ◽  
Childhood Adversity ◽  
Genetic Profile ◽  
Acute And Chronic Stress ◽  
Adolescent Depressive Symptoms ◽  
Gene Environment

AbstractResearch suggests that genetic variants linked to hypothalamic-pituitary-adrenal (HPA)-axis functioning moderate the association between environmental stressors and depression, but examining gene–environment interactions with single polymorphisms limits power. The current study used a multilocus genetic profile score (MGPS) approach to measuring HPA-axis–related genetic variation and examined interactions with acute stress, chronic stress, and childhood adversity (assessed using contextual threat interview methods) with depressive symptoms as outcomes in an adolescent sample (ages 14–17, N = 241; White subsample n = 192). Additive MGPSs were calculated using 10 single nucleotide polymorphisms within HPA-axis genes (CRHR1, NR3C2, NR3C1, FKBP5). Higher MGPS directly correlated with adolescent depressive symptoms. Moreover, MGPS predicted stronger associations between acute and chronic stress and adolescent depressive symptoms and also moderated the effect of interpersonal, but not noninterpersonal, childhood adversity. Gene–environment interactions individually accounted for 5%–8% of depressive symptom variation. All results were retained following multiple test correction and stratification by race. Results suggest that using MGPSs provides substantial power to examine gene–environmental interactions linked to affective outcomes among adolescents.

scholarly journals A Review of Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Cara Tomas ◽  
Julia Newton ◽  
Stuart Watson
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Hpa Axis ◽  
Treatment Strategies ◽  
Chronic Fatigue ◽  
Interindividual Variation ◽  
Genetic Profile ◽  
Hypothalamic Pituitary Adrenal ◽  
Fatigue Syndrome ◽  
Novel Treatment Strategies ◽  
The Impact

Hypothalamic-pituitary-adrenal (HPA) axis dysfunction has been found in a high proportion of chronic fatigue syndrome (CFS) patients and includes enhanced corticosteroid-induced negative feedback, basal hypocortisolism, attenuated diurnal variation, and a reduced responsivity to challenge. A putative causal role for genetic profile, childhood trauma, and oxidative stress has been considered. In addition, the impact of gender is demonstrated by the increased frequency of HPA axis dysregulation in females. Despite the temporal relationship, it is not yet established whether the endocrine dysregulation is causal, consequent, or an epiphenomenon of the disorder. Nonetheless, given the interindividual variation in the effectiveness of existing biological and psychological treatments, the need for novel treatment strategies such as those which target the HPA axis is clear.

Interpersonal Stress and Poor Health

2010 ◽  
Vol 15 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Mette M. Aanes ◽  
Maurice B. Mittelmark ◽  
Jørn Hetland
Keyword(s):  
Psychological Distress ◽  
Depressive Symptoms ◽  
Social Relationships ◽  
Indirect Effects ◽  
Social Connectedness ◽  
Somatic Symptoms ◽  
Total Effect ◽  
Subjective Feeling ◽  
Interpersonal Stress ◽  
The Relationship

This paper investigated whether the lack of social connectedness, as measured by the subjective feeling of loneliness, mediates the well-known relationship between interpersonal stress and psychological distress. Furthermore, a relationship between interpersonal stress and somatic symptoms was hypothesized. The study sample included 3,268 women and 3,220 men in Western Norway. The main findings were that interpersonal stress was significantly related to psychological distress as well as to somatic symptoms, both directly and indirectly via paths mediated by loneliness. The size of the indirect effects varied, suggesting that the importance of loneliness as a possible mediator differs for depressive symptoms, anxiety symptoms, and somatic symptoms. In the case of depressive symptoms, more than 75% of the total effect was mediated through loneliness, while in the case of somatic symptoms just over 40% of the total effect was mediated through loneliness. This study supports the hypotheses that social connectedness mediates a relationship between interpersonal stress and psychological distress. The study also provides the first link between interpersonal stress, as measured by the Bergen Social Relationships Scale, and somatic symptoms, extending earlier research on the relationship between interpersonal stress and psychological distress.

Impact of an educative program on dialysis patients’ knowledge and mental health: controlled before and after program

2018 ◽  
Vol 10 (2) ◽  
pp. 20204
Author(s):  
Laetitia Idier ◽  
Aurélie Untas ◽  
Nicole Rascle ◽  
Michèle Koleck ◽  
Maider Aguirrezabal ◽  
...  
Keyword(s):  
Mental Health ◽  
Depressive Symptoms ◽  
Vascular Access ◽  
Educational Program ◽  
Psychological State ◽  
Control Group ◽  
Dialysis Patients ◽  
Emotional Change ◽  
The Impact ◽  
Experimental Group

Introduction:Psychological impact of Therapeutic Patient Education (TPE) for dialysis patients is rarely evaluated since the focus of many studies is on medical variables (i.e., adherence).Objectives:The aims of this study were: 1) to estimate the impact of a TPE program on knowledge, depression and anxiety, 2) to examine change in knowledge as a mediator of the effects of a TPE program on mental health.Method:This study was conducted in three hemodialysis units and comprised two groups: an experimental group with education and a control group with routine care. The program was based of 5 educative sessions. Knowledge, depressive and anxious symptoms were assessed with self-reported outcomes measured before and 3 months after the program.Results:The sample comprised 125 patients. Knowledge about vascular access and nutrition (p < 0.01) and depressive symptoms increased in the experimental group (p < 0.01). Analysis of mediation showed that changes in knowledge about vascular access were a significant mediator of the effects of the program on depressive symptoms (F = 4.90;p = 0.01).Discussion:Knowledge acquired during an educational program could lead to an emotional change. Improving knowledge often leads to an awareness of the risks that can modify the psychological state of patients by reminding them of their vulnerability. This study shows that it is required to be attentive to the way of transmitting knowledge. It’s necessary adapting this transmission to the needs of patients and promoting the acquisition of psychosocial competence too.Conclusion:This study shows that knowledge acquired during an educational program can lead to an emotional change in the short term. A long-term follow-up of the population should be interesting to observe these emotional effects.

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