When less equals more: Probability summation without sensitivity improvement.

2014 ◽  
Vol 40 (5) ◽  
pp. 2091-2100 ◽  
Author(s):  
Wolf Schwarz ◽  
Jeff O. Miller
Keyword(s):  
Probability Summation ◽  
Sensitivity Improvement

scholarly journals Ball-lens assisted sensitivity improvement of fluorescence immunoassay in microchannels

RSC Advances ◽  
2021 ◽  
Vol 11 (44) ◽  
pp. 27541-27546
Author(s):  
Qingquan Zhang ◽  
Jiajia Li ◽  
Yuting Su ◽  
Xiaoyan Pan ◽  
Hongwei Gai
Keyword(s):  
Fluorescence Immunoassay ◽  
Improvement Method ◽  
Sensitivity Improvement

A contactless and ball-lens assisted sensitivity improvement method was present for the fluorescence or luminescence immunoassay in microchannel.

Exercise training prevents maturation-induced decrease in insulin sensitivity

1996 ◽  
Vol 80 (6) ◽  
pp. 1963-1967 ◽  
Author(s):  
N. Nakai ◽  
Y. Shimomura ◽  
N. Ohsaki ◽  
J. Sato ◽  
Y. Oshida ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Exercise Training ◽  
Infusion Rate ◽  
Glucose Transporter ◽  
Euglycemic Clamp ◽  
Glut 4 ◽  
Hindlimb Muscle ◽  
Female Wistar Rats ◽  
Sensitivity Improvement

We examined the effects of exercise training initiated before maturation or after maturation on insulin sensitivity and glucose transporter GLUT-4 content in membrane fractions of skeletal muscle. Female Wistar rats (4 wk of age) were divided into sedentary and exercise-trained groups. At 12 wk of age, a subset of the trained animals (Tr) was killed along with a subset of sedentary controls (Sed). One-half of the remaining sedentary animals remained sedentary (Sed-Sed) while the other half began exercise training (Sed-Tr). The remaining rats in the original trained group continued to train (Tr-Tr). Euglycemic clamp (insulin infusion rate at 6 mU.kg body wt-1. min-1) was performed at 4, 12, and 27 wk. After euglycemic clamp in all animals except the 4-wk-old, hindlimb (gastrocnemius and part of quadriceps) muscles were removed for preparation of membrane fractions. In sedentary rats, glucose infusion rate (GIR) during euglycemic clamp was decreased from 15.9 mg.kg-1.min-1 at 4 wk of age to 9.8 mg.kg-1.min-1 at 12 wk of age and 9.1 mg.kg-1.min-1 at 27 wk of age. In exercise-trained rats, the GIR was not significantly decreased by maturation (at 12 wk) and further aging (at 27 wk). Initiation of exercise after maturation restored the GIR at 27 wk of age to the same levels as these for the corresponding exercise-trained rats. GLUT-4 content in plasma and intracellular membrane fractions of hindlimb muscle obtained just after euglycemic clamp showed the same trend as the results of GIR. These results suggest that exercise training prevented the maturation-induced decrease in insulin sensitivity. Improvement of insulin sensitivity caused by exercise training was attributed, at least in part, to the increase in insulin-sensitive GLUT-4 on the plasma membrane in skeletal muscle.

Sensitivity Improvement in Electrochemical Immunoassays Using Antibody Immobilized Magnetic Nanoparticles with a Clean ITO Working Electrode

2020 ◽  
Vol 14 (3) ◽  
pp. 308-316
Author(s):  
Sunga Song ◽  
Young Joo Kim ◽  
Hye-Lim Kang ◽  
Sumi Yoon ◽  
Dong-Ki Hong ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Working Electrode ◽  
Sensitivity Improvement ◽  
Electrochemical Immunoassays
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