scholarly journals Replication RCT of early universal prevention effects on young adult substance misuse.

2014 ◽  
Vol 82 (6) ◽  
pp. 949-963 ◽  
Author(s):  
Richard Spoth ◽  
Linda Trudeau ◽  
Cleve Redmond ◽  
Chungyeol Shin
Keyword(s):  
Young Adult ◽  
Substance Misuse ◽  
Universal Prevention

scholarly journals Young adult mental health and functional outcomes among individuals with remitted, persistent and late-onset ADHD

2018 ◽  
Vol 213 (3) ◽  
pp. 526-534 ◽  
Author(s):  
Jessica C. Agnew-Blais ◽  
Guilherme V. Polanczyk ◽  
Andrea Danese ◽  
Jasmin Wertz ◽  
Terrie E. Moffitt ◽  
...  
Keyword(s):  
Mental Health ◽  
Young Adult ◽  
Conduct Disorder ◽  
Physical Health ◽  
Young Adulthood ◽  
Substance Misuse ◽  
Late Onset ◽  
Developmental Patterns ◽  
Socioeconomic Outcomes ◽  
Childhood Conduct

BackgroundAttention-deficit hyperactivity disorder (ADHD) is associated with mental health problems and functional impairment across many domains. However, how the longitudinal course of ADHD affects later functioning remains unclear.AimsWe aimed to disentangle how ADHD developmental patterns are associated with young adult functioning.MethodThe Environmental Risk (E-Risk) Longitudinal Twin Study is a population-based cohort of 2232 twins born in England and Wales in 1994–1995. We assessed ADHD in childhood at ages 5, 7, 10 and 12 years and in young adulthood at age 18 years. We examined three developmental patterns of ADHD from childhood to young adulthood – remitted, persistent and late-onset ADHD – and compared these groups with one another and with non-ADHD controls on functioning at age 18 years. We additionally tested whether group differences were attributable to childhood IQ, childhood conduct disorder or familial factors shared between twins.ResultsCompared with individuals without ADHD, those with remitted ADHD showed poorer physical health and socioeconomic outcomes in young adulthood. Individuals with persistent or late-onset ADHD showed poorer functioning across all domains, including mental health, substance misuse, psychosocial, physical health and socioeconomic outcomes. Overall, these associations were not explained by childhood IQ, childhood conduct disorder or shared familial factors.ConclusionsLong-term associations of childhood ADHD with adverse physical health and socioeconomic outcomes underscore the need for early intervention. Young adult ADHD showed stronger associations with poorer mental health, substance misuse and psychosocial outcomes, emphasising the importance of identifying and treating adults with ADHD.Declaration of interestNone.

scholarly journals Effects of Adolescent Universal Substance Misuse Preventive Interventions on Young Adult Depression Symptoms: Mediational Modeling

2015 ◽  
Vol 44 (2) ◽  
pp. 257-268 ◽  
Author(s):  
Linda Trudeau ◽  
Richard Spoth ◽  
W. Alex Mason ◽  
G. Kevin Randall ◽  
Cleve Redmond ◽  
...  
Keyword(s):  
Young Adult ◽  
Substance Misuse ◽  
Depression Symptoms ◽  
Preventive Interventions ◽  
Adult Depression

Fine Structure of Interdental Cells in the Mouse Cochlea

1970 ◽  
Vol 28 ◽  
pp. 140-141
Author(s):  
Roberta M. Bruck
Keyword(s):  
Fine Structure ◽  
Electron Microscope ◽  
Young Adult ◽  
Uranyl Acetate ◽  
Ground Substance ◽  
Tectorial Membrane ◽  
Lead Citrate ◽  
Unusual Structure ◽  
Thin Sections ◽  
Collagenous Fibers

An unusual structure in the cochlea is the spiral limbus; this periosteal tissue consists of stellate fibroblasts and collagenous fibers embedded in a translucent ground substance. The collagenous fibers are arranged in vertical columns (the auditory teeth of Haschke). Between the auditory teeth are interdental furrows in which the interdental cells are situated. These epithelial cells supposedly secrete the tectorial membrane.The fine structure of interdental cells in the rat was reported by Iurato (1962). Since the mouse appears to be different, a description of the fine structure of mouse interdental cells' is presented. Young adult C57BL/6J mice were perfused intervascularly with 1% paraformaldehyde/ 1.25% glutaraldehyde in .1M phosphate buffer (pH7.2-7.4). Intact cochlea were decalcified in .1M EDTA by the method of Baird (1967), postosmicated, dehydrated, and embedded in Araldite. Thin sections stained with uranyl acetate and lead citrate were examined in a Phillips EM-200 electron microscope.

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