The effects of parity and maternal behavior on gene expression in the medial preoptic area and the medial amygdala in postpartum and virgin female rats: A microarray study.

2013 ◽  
Vol 127 (6) ◽  
pp. 913-922 ◽  
Author(s):  
Emis M. Akbari ◽  
Soaleha Shams ◽  
Hiwote T. Belay ◽  
Mo Kaiguo ◽  
Zak Razak ◽  
...  
Keyword(s):  
Gene Expression ◽  
Maternal Behavior ◽  
Preoptic Area ◽  
Virgin Female ◽  
Medial Preoptic Area ◽  
Female Rats ◽  
Medial Amygdala ◽  
Microarray Study

Excitotoxic Amino Acid Injections into the Medial Amygdala Facilitate Maternal Behavior in Virgin Female Rats

1993 ◽  
Vol 27 (1) ◽  
pp. 56-81 ◽  
Author(s):  
Michael Numan ◽  
Marilyn J. Numan ◽  
Jeffrey B. English
Keyword(s):  
Amino Acid ◽  
Maternal Behavior ◽  
Virgin Female ◽  
Female Rats ◽  
Medial Amygdala

scholarly journals Reproductive Experience Increases Prolactin Responsiveness in the Medial Preoptic Area and Arcuate Nucleus of Female Rats

Endocrinology ◽  
2006 ◽  
Vol 147 (10) ◽  
pp. 4688-4694 ◽  
Author(s):  
Greg M. Anderson ◽  
David R. Grattan ◽  
Willemijn van den Ancker ◽  
Robert S. Bridges
Keyword(s):  
Maternal Behavior ◽  
Maternal Care ◽  
Arcuate Nucleus ◽  
Preoptic Area ◽  
Medial Preoptic Area ◽  
Prolactin Secretion ◽  
Receptor Expression ◽  
Female Rats ◽  
Prolactin Receptors ◽  
Reproductive Experience

The experience of pregnancy plus lactation produces long-term enhancements in maternal behavior as well as reduced secretion of prolactin, a key hormone for the initial establishment of maternal care. Given that prolactin acts centrally to induce maternal care as well as regulate its own secretion, we tested whether prolactin receptors in brain regions known to regulate behavioral and neuroendocrine processes were up-regulated and more responsive to prolactin in reproductively experienced females. Diestrous primiparous (8 wk after weaning) and age-matched virgin rats were treated with 250 μg ovine prolactin sc or vehicle and the brains collected 2 h later for measurement of mRNA for genes involved in prolactin signaling. Reproductively experienced rats had lower serum prolactin concentrations, compared with virgin rats, suggesting enhanced prolactin feedback on the arcuate neurons regulating prolactin secretion. In the medial preoptic area and arcuate nucleus (regions involved in regulating maternal behavior and prolactin secretion, respectively), the level of long-form prolactin receptor mRNA was higher in primiparous rats, and prolactin treatment induced a further increase in receptor expression in these animals. In the same regions, suppressors of cytokine signaling-1 and -3 mRNA levels were also markedly increased after prolactin treatment in reproductively experienced but not virgin rats. These results support the idea that reproductive experience increases central prolactin responsiveness. The induction of prolactin receptors and enhanced prolactin responsiveness as a result of pregnancy and lactation may help account for the retention of maternal behavior and shifts in prolactin secretion in reproductively experienced females.

scholarly journals The Increase in Signaling by Kisspeptin Neurons in the Preoptic Area and Associated Changes in Clock Gene Expression That Trigger the LH Surge in Female Rats Are Dependent on the Facilitatory Action of a Noradrenaline Input

Endocrinology ◽  
2016 ◽  
Vol 157 (1) ◽  
pp. 323-335 ◽  
Author(s):  
Bruna Kalil ◽  
Aline B. Ribeiro ◽  
Cristiane M. Leite ◽  
Ernane T. Uchôa ◽  
Ruither O. Carolino ◽  
...  
Keyword(s):  
Gene Expression ◽  
Median Eminence ◽  
Preoptic Area ◽  
Clock Genes ◽  
Third Ventricle ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Lh Surge ◽  
Clock Gene Expression

Abstract In rodents, kisspeptin neurons in the rostral periventricular area of the third ventricle (RP3V) of the preoptic area are considered to provide a major stimulatory input to the GnRH neuronal network that is responsible for triggering the preovulatory LH surge. Noradrenaline (NA) is one of the main modulators of GnRH release, and NA fibers are found in close apposition to kisspeptin neurons in the RP3V. Our objective was to interrogate the role of NA signaling in the kisspeptin control of GnRH secretion during the estradiol induced LH surge in ovariectomized rats, using prazosin, an α1-adrenergic receptor antagonist. In control rats, the estradiol-induced LH surge at 17 hours was associated with a significant increase in GnRH and kisspeptin content in the median eminence with the increase in kisspeptin preceding that of GnRH and LH. Prazosin, administered 5 and 3 hours prior to the predicted time of the LH surge truncated the LH surge and abolished the rise in GnRH and kisspeptin in the median eminence. In the preoptic area, prazosin blocked the increases in Kiss1 gene expression and kisspeptin content in association with a disruption in the expression of the clock genes, Per1 and Bmal1. Together these findings demonstrate for the first time that NA modulates kisspeptin synthesis in the RP3V through the activation of α1-adrenergic receptors prior to the initiation of the LH surge and indicate a potential role of α1-adrenergic signaling in the circadian-controlled pathway timing of the preovulatory LH surge.

Effects of small medial preoptic area lesions on maternal behavior: Retreiving and nest building in the rat

1980 ◽  
Vol 194 (2) ◽  
pp. 471-478 ◽  
Author(s):  
Carol D. Jacobson ◽  
Joseph Terkel ◽  
Roger A. Gorski ◽  
Charles H. Sawyer
Keyword(s):  
Maternal Behavior ◽  
Preoptic Area ◽  
Medial Preoptic Area ◽  
Nest Building
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