scholarly journals Rapid effects of 17β-estradiol on male copulatory behaviors are not elicited by the novel membrane active estrogenic compound STX.

2013 ◽  
Vol 127 (4) ◽  
pp. 598-605 ◽  
Author(s):  
Katherine R. Kaufman ◽  
Martin J. Kelly ◽  
Charles E. Roselli
Keyword(s):  
The Novel ◽  
Estrogenic Compound ◽  
17Β Estradiol

scholarly journals Estradiol, Progesterone, Immunomodulation, and COVID-19 Outcomes

Endocrinology ◽  
2020 ◽  
Vol 161 (9) ◽  
Author(s):  
Franck Mauvais-Jarvis ◽  
Sabra L Klein ◽  
Ellis R Levin
Keyword(s):  
Immune Response ◽  
Distress Syndrome ◽  
Immune Dysregulation ◽  
Innate Immune ◽  
The Novel ◽  
Cytokine Storm ◽  
Inflammatory Infiltration ◽  
Biological Sex ◽  
17Β Estradiol ◽  
Novel Coronavirus

Abstract Severe outcomes and death from the novel coronavirus disease 2019 (COVID-19) appear to be characterized by an exaggerated immune response with hypercytokinemia leading to inflammatory infiltration of the lungs and acute respiratory distress syndrome. Risk of severe COVID-19 outcomes is consistently lower in women than men worldwide, suggesting that female biological sex is instrumental in protection. This mini-review discusses the immunomodulatory and anti-inflammatory actions of high physiological concentrations of the steroids 17β-estradiol (E2) and progesterone (P4). We review how E2 and P4 favor a state of decreased innate immune inflammatory response while enhancing immune tolerance and antibody production. We discuss how the combination of E2 and P4 may improve the immune dysregulation that leads to the COVID-19 cytokine storm. It is intended to stimulate novel consideration of the biological forces that are protective in women compared to men, and to therapeutically harness these factors to mitigate COVID-19 morbidity and mortality.

scholarly journals Functional Significance of Nuclear Estrogen Receptor Subtypes in the Liver of Goldfish

Endocrinology ◽  
2010 ◽  
Vol 151 (4) ◽  
pp. 1668-1676 ◽  
Author(s):  
Erik R. Nelson ◽  
Hamid R. Habibi
Keyword(s):  
Strong Support ◽  
Somatic Growth ◽  
Egg Yolk ◽  
Receptor Subtypes ◽  
The Novel ◽  
Functional Roles ◽  
Knock Down ◽  
Functional Involvement ◽  
17Β Estradiol ◽  
Nuclear Estrogen Receptor

Estrogens work by binding to and activating specific estrogen receptors (ERs). Although mammals have two major nuclear ER subtypes (ERα and ERβ), three subtypes have been shown in teleost fish (ERα, ERβ-I, and ERβ-II). 17β-Estradiol stimulates the production of an egg yolk precursor protein (vitellogenin) in the liver of oviparous species, including the goldfish. However, the functional involvement of the ER subtypes in this process is not fully understood. Here, using primary goldfish hepatocytes, we test the hypothesis that all three ER subtypes are functionally involved in the liver of goldfish by using RNA interference to specifically knock-down the different ER subtypes. The results suggest that ERα is induced by estradiol through activation of the ERβ subtypes. This induction serves to sensitize the liver to further stimulation by estradiol. The knock-down results were supported by use of ER subtype specific antagonists. Sensitization by up-regulation of ERα is likely to be important for seasonal spawners such as goldfish, to bring about a change from somatic growth to reproductive development, and vitellogenesis. The novel data presented in this study provide strong support for the hypothesis that the goldfish ER subtypes play functional roles in the regulation of vitellogenin and ERα and provide a framework for the better understanding of ER signaling in fish and other vertebrates.

scholarly journals 17β-Estradiol-Induced Regulation of the Novel 5-HT1A-Related Transcription Factors NUDR and Freud-1 in SH SY5Y Cells

2012 ◽  
Vol 32 (4) ◽  
pp. 517-521 ◽  
Author(s):  
Samuel O. Adeosun ◽  
Paul R. Albert ◽  
Mark C. Austin ◽  
Abiye H. Iyo
Keyword(s):  
Transcription Factors ◽  
The Novel ◽  
17Β Estradiol

The novel steroidal glycoside from the dried bulb of Allium Macrostemon Bunge inhibits platelet activation

2010 ◽  
Vol 34 (8) ◽  
pp. S33-S33
Author(s):  
Wenchao Ou ◽  
Haifeng Chen ◽  
Yun Zhong ◽  
Benrong Liu ◽  
Keji Chen
Keyword(s):  
Platelet Activation ◽  
The Novel ◽  
Steroidal Glycoside ◽  
Allium Macrostemon
Sign in / Sign up

Export Citation Format

Share Document