Chronic mild stress increases alcohol intake in mice with low dopamine D2 receptor levels.

2013 ◽  
Vol 127 (1) ◽  
pp. 95-105 ◽  
Author(s):  
Foteini Delis ◽  
Panayotis K. Thanos ◽  
Christina Rombola ◽  
Lauren Rosko ◽  
David Grandy ◽  
...  
Keyword(s):  
Alcohol Intake ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Dopamine D2

scholarly journals Mesolimbic dopamine D2 receptor plasticity contributes to stress resilience in rats subjected to chronic mild stress

2013 ◽  
Vol 227 (4) ◽  
pp. 583-593 ◽  
Author(s):  
Dariusz Żurawek ◽  
Agata Faron-Górecka ◽  
Maciej Kuśmider ◽  
Magdalena Kolasa ◽  
Piotr Gruca ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Mesolimbic Dopamine ◽  
Stress Resilience ◽  
Dopamine D2 ◽  
Receptor Plasticity

Elevated dopamine D2 receptor in prefrontal cortex of CUMS rats is associated with downregulated cAMP-independent signaling pathway

2013 ◽  
Vol 91 (9) ◽  
pp. 750-758 ◽  
Author(s):  
Cheng Chen ◽  
Jing-mo Yang ◽  
Ting-ting Hu ◽  
Ting-juan Xu ◽  
Wei-ping Xu ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Chronic Stress ◽  
Rat Model ◽  
Functional Disability ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Mild Stress ◽  
Pathophysiological Mechanism ◽  
Dopaminergic Receptors ◽  
Dopamine D2

Because depression is associated with significant morbidity and functional disability, it is important to reveal the mechanism of action. A variety of studies have suggested the involvement of dopaminergic receptors in the pathophysiological mechanism of non-stress-associated depression-like behavior in rodents. Nevertheless, controversy exists about whether chronic stress acts on dopaminergic receptors in the prefrontal cortex. Thus, we investigated the level of dopamine D2 receptors (DRD2) and the possible mechanisms involved in a chronic unpredictable mild stress (CUMS) rat model of depression. The results showed CUMS-induced, depression-like symptoms in the rat, characterized by reduced sucrose consumption and body mass, and increased duration of immobility in a forced swimming test. Moreover, chronic stress upregulated the expression of DRD2 but downregulated protein kinase A (PKA), transcription factor cAMP response element binding protein (CREB), and phospho-CREB (p-CREB) in the prefrontal cortex, as demonstrated by Western blot. Notably, in the rat model of depression, decreased cyclic adenine monophosphate (cAMP) levels and PKA activity were present at the same time, which is consistent with clinical findings in depressed patients. Our findings suggested that dopaminergic system dysfunction could play a central role in stress-related disorders such as depression.

scholarly journals What Do the Animal Studies of Stress Resilience Teach Us?

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1630
Author(s):  
Marta Dziedzicka-Wasylewska ◽  
Joanna Solich ◽  
Agata Korlatowicz ◽  
Agata Faron-Górecka
Keyword(s):  
Animal Models ◽  
Animal Studies ◽  
Depressive Disorders ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Chronic Mild Stress ◽  
Stress Factors ◽  
Mild Stress ◽  
Stress Resilience ◽  
Molecular Features

Long-lasting stress factors, both biological and psychological, are commonly accepted as the main cause of depressive disorders. Several animal models, using various stressful stimuli, have been used to find biochemical and molecular alterations that could help us understand the etiopathogenesis of depression. However, recent sophisticated studies indicate that the most frequently used animal models of stress only capture a portion of the molecular features associated with complex human disorders. On the other hand, some of these models generate groups of animals resilient to stress. Studies of the mechanisms of stress resilience bring us closer to understanding the process of adapting to aversive stimuli and the differences between stress-susceptible vs. resilient phenotypes. Especially interesting in this context is the chronic mild stress (CMS) experimental paradigm, most often using rats. Studies using this animal model have revealed that biochemical (e.g., the dopamine D2 receptor) and molecular (e.g., microRNA) alterations are dynamic (i.e., depend on stress duration, 2 vs. 7 weeks) and much more pronounced in stress-resilient than stress-susceptible groups of animals. We strongly suggest that studies aimed at understanding the molecular and biochemical mechanisms of depression must consider these dynamics. A good candidate to serve as a biomarker in such studies might be serum microRNA, since it can be obtained relatively easily from living individuals at various time points.

Effect of amphetamine on dopamine D2 receptor binding in the primate brain with the agonist ligand [11C]MNPA

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S646-S646
Author(s):  
Nicholas Seneca ◽  
Sjoerd Finnema ◽  
Masanori Ichise ◽  
Balazs Gulyas ◽  
Håkan Wikstrom ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D2 ◽  
Primate Brain
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