Automatic risk behavior: Direct effects of binge drinker stereotypes on drinking behavior.

Amanda Rivis; Paschal Sheeran

doi:10.1037/a0029859

Angiotensins in the central mechanisms of drinking instrumental activity of rats with different manifestations of risk behavior

I P Pavlov Russian Medical Biological Herald ◽

10.23888/pavlovj20182222-228 ◽

2018 ◽

Vol 26 (2) ◽

pp. 222-228

Author(s):

Roman Ya. Vlasenko ◽

Alexander V. Kotov

Keyword(s):

Risk Behavior ◽

Lateral Ventricle ◽

Soft Tissues ◽

Drinking Behavior ◽

Male Rats ◽

Internal Diameter ◽

Instrumental Activity ◽

The Usa ◽

The Brain ◽

Purposive Behavior

Aim. To carry out a comparative analysis of characteristics of drinking instrumental activity in rats with different manifestation of risk behavior before and after intracerebral introduction of equally productive dipsogenic doses of angiotensins. Materials and Мethods. The work was conducted on 19 Wistar male rats of 250300 g mass. All manipulations with animals were performed in accordance with the international ethic recommendations on biomedical research with use of animals. All rats were preliminarily scalped under ether anesthesia with removal of soft tissues and periosteum. The cannulae were introduced into rat’s brain through the trephine opening in the lateral ventricle. The length of each cannula was 8 mm, the internal diameter – 0.8 mm. All cannulae had a special restrictor at the distance of about 3.5 mm from the implantable end. Each animal was implanted one cannula into the lateral ventricle of the brain on the right or left side according to the coordinates of stereotaxic atlas for rats (L.D. Pellegrino at al., 1979) (AP = +1.0; L= 2; H= 2.5). Microinjections of substances were made into the brain of nonnarcotized animals using a microsyringe of 5 μL volume («Hamilton», the USA). For intraventricular microinjections, angiotensinII, angiotensinIII and [des – Asp1]angiotensinI («Sigma», the USA) were used. Results. In the article the mechanisms of realization of drinking instrumental activity in rats with different manifestations of risk behavior are described. In view of P.K. Anokhin’s general theory of functional systems, the effects of application of «equally productive» doses of angiotensins on initiation of specific patterns of drinking behavior in rats are discussed. Risk is considered as an independent component of systemic organization of purposive behavior of an individual. It is shown that the «integral pattern of individual behavior» of rats is selectively modulated by angiotensinII and angiotensinIII. This selectivity has a narrow focus and individual manifestations, depending on the background activity of the animals. Conclusion. Depending on the initial level of the intensity of instrumental activity of the animals (with different manifestations of risk behavior), angiotensin II and angiotensin III are involved into initiation of fullscale «integral pattern of individual drinking behavior» or participate in the directed modulation of complex purposive behavior manifested by enhancement of dipsogenic effect. At the same time, [des – Asp1]angiotensinI does not participate in the mechanisms of reproduction of the acquired drinking instrumental habits but induces only mechanisms of initiation of congenital individual forms of drinking behavior.

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Angiotensins in the central mechanisms of drinking instrumental activity of rats with different manifestations of risk behavior

I P Pavlov Russian Medical Biological Herald ◽

10.23888/pavlovj2018262222-228 ◽

2018 ◽

Vol 26 (2) ◽

pp. 222-228

Author(s):

Roman Ya. Vlasenko ◽

Alexander V. Kotov

Keyword(s):

Risk Behavior ◽

Lateral Ventricle ◽

Soft Tissues ◽

Drinking Behavior ◽

Male Rats ◽

Internal Diameter ◽

Instrumental Activity ◽

The Usa ◽

The Brain ◽

Purposive Behavior

Aim. To carry out a comparative analysis of characteristics of drinking instrumental activity in rats with different manifestation of risk behavior before and after intracerebral introduction of equally productive dipsogenic doses of angiotensins. Materials and Мethods. The work was conducted on 19 Wistar male rats of 250300 g mass. All manipulations with animals were performed in accordance with the international ethic recommendations on biomedical research with use of animals. All rats were preliminarily scalped under ether anesthesia with removal of soft tissues and periosteum. The cannulae were introduced into rat’s brain through the trephine opening in the lateral ventricle. The length of each cannula was 8 mm, the internal diameter – 0.8 mm. All cannulae had a special restrictor at the distance of about 3.5 mm from the implantable end. Each animal was implanted one cannula into the lateral ventricle of the brain on the right or left side according to the coordinates of stereotaxic atlas for rats (L.D. Pellegrino at al., 1979) (AP = +1.0; L= 2; H= 2.5). Microinjections of substances were made into the brain of nonnarcotized animals using a microsyringe of 5 μL volume («Hamilton», the USA). For intraventricular microinjections, angiotensinII, angiotensinIII and [des – Asp1]angiotensinI («Sigma», the USA) were used. Results. In the article the mechanisms of realization of drinking instrumental activity in rats with different manifestations of risk behavior are described. In view of P.K. Anokhin’s general theory of functional systems, the effects of application of «equally productive» doses of angiotensins on initiation of specific patterns of drinking behavior in rats are discussed. Risk is considered as an independent component of systemic organization of purposive behavior of an individual. It is shown that the «integral pattern of individual behavior» of rats is selectively modulated by angiotensinII and angiotensinIII. This selectivity has a narrow focus and individual manifestations, depending on the background activity of the animals. Conclusion. Depending on the initial level of the intensity of instrumental activity of the animals (with different manifestations of risk behavior), angiotensin II and angiotensin III are involved into initiation of fullscale «integral pattern of individual drinking behavior» or participate in the directed modulation of complex purposive behavior manifested by enhancement of dipsogenic effect. At the same time, [des – Asp1]angiotensinI does not participate in the mechanisms of reproduction of the acquired drinking instrumental habits but induces only mechanisms of initiation of congenital individual forms of drinking behavior.

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Direct effects of hCG on the human endometrium

Journal of the Society for Gynecologic Investigation ◽

10.1016/s1071-5576(97)86364-2 ◽

1998 ◽

Vol 5 (1) ◽

pp. 109A-109A ◽

Cited By ~ 1

Author(s):

R FANCHIN ◽

E PELTIER ◽

C RIGHINI ◽

F OLIVENNES ◽

R FRYDMAN ◽

...

Keyword(s):

Human Endometrium ◽

Direct Effects

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Childhood Intelligence Predicts Adult Trait Openness

Journal of Individual Differences ◽

10.1027/1614-0001/a000194 ◽

2016 ◽

Vol 37 (2) ◽

pp. 105-111 ◽

Cited By ~ 6

Author(s):

Adrian Furnham ◽

Helen Cheng

Keyword(s):

Structural Equation Modeling ◽

Structural Equation ◽

Social Background ◽

Study Data ◽

Equation Modeling ◽

Direct Effects ◽

Data Set ◽

National Child Development Study ◽

Nationally Representative ◽

The Uk

Abstract. This study used a longitudinal data set of 5,672 adults followed for 50 years to determine the factors that influence adult trait Openness-to-Experience. In a large, nationally representative sample in the UK (the National Child Development Study), data were collected at birth, in childhood (age 11), adolescence (age 16), and adulthood (ages 33, 42, and 50) to examine the effects of family social background, childhood intelligence, school motivation during adolescence, education, and occupation on the personality trait Openness assessed at age 50 years. Structural equation modeling showed that parental social status, childhood intelligence, school motivation, education, and occupation all had modest, but direct, effects on trait Openness, among which childhood intelligence was the strongest predictor. Gender was not significantly associated with trait Openness. Limitations and implications of the study are discussed.

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