scholarly journals Peer network drinking predicts increased alcohol use from adolescence to early adulthood after controlling for genetic and shared environmental selection.

2012 ◽  
Vol 48 (5) ◽  
pp. 1390-1402 ◽  
Author(s):  
Jennifer E. Cruz ◽  
Robert E. Emery ◽  
Eric Turkheimer
Keyword(s):  
Alcohol Use ◽  
Early Adulthood ◽  
Environmental Selection ◽  
Peer Network

Polygenic Scores Predict the Development of Alcohol and Nicotine Use Problems from Adolescence through Young Adulthood

2020 ◽  
Author(s):  
Joseph D. Deak ◽  
D. Angus Clark ◽  
Mengzhen Liu ◽  
C. Emily Durbin ◽  
William G. Iacono ◽  
...  
Keyword(s):  
Substance Use ◽  
Alcohol Use ◽  
Young Adulthood ◽  
Externalizing Behavior ◽  
Molecular Genetic ◽  
Early Adulthood ◽  
Predictive Utility ◽  
Problematic Use ◽  
Discovery Sample ◽  
Polygenic Scores

Objective: Molecular genetic studies of alcohol and nicotine have identified many genome-wide loci. We examined the predictive utility of drinking and smoking polygenic scores (PGS) for alcohol and nicotine use from late childhood to early adulthood, substance-specific versus broader-liability PGS effects, and if PGS performance varied between consumption versus pathological use. Methods: Latent growth curve models with structured residuals were used to assess the predictive utility of drinks per week and regular smoking PGS for measures of alcohol and nicotine consumption and problematic use from age 14 to 34. PGSs were generated from the largest discovery sample for alcohol and nicotine use to date (i.e., GSCAN), and examined for associations with alcohol and nicotine use in the Minnesota Twin Family Study (N=3225).Results: The drinking PGS was a significant predictor of age 14 problematic alcohol use and increases in problematic use during young adulthood. The smoking PGS was a significant predictor for all nicotine use outcomes. After adjusting for the effects of both PGSs, the smoking PGS demonstrated incremental predictive utility for most alcohol use outcomes and remained a significant predictor of nicotine use trajectories. Conclusions: Higher PGS for drinking and smoking were associated with more problematic levels of substance use longitudinally. The smoking PGS seems to capture both nicotine-specific and non-specific genetic liability for substance use, and may index genetic risk for broader externalizing behavior. Validation of PGS within longitudinal designs may have important clinical implications should future studies support the clinical utility of PGS for substance use disorders.

scholarly journals Polygenic Scores Predict the Development of Alcohol and Nicotine Use Problems from Adolescence through Young Adulthood

2020 ◽  
Author(s):  
Joseph D. Deak ◽  
D. Angus Clark ◽  
Mengzhen Liu ◽  
C. Emily Durbin ◽  
William G. Iacono ◽  
...  
Keyword(s):  
Substance Use ◽  
Alcohol Use ◽  
Young Adulthood ◽  
Externalizing Behavior ◽  
Molecular Genetic ◽  
Early Adulthood ◽  
Predictive Utility ◽  
Problematic Use ◽  
Discovery Sample ◽  
Polygenic Scores

AbstractObjectiveMolecular genetic studies of alcohol and nicotine have identified many genome-wide loci. We examined the predictive utility of drinking and smoking polygenic scores (PGS) for alcohol and nicotine use from late childhood to early adulthood, substance-specific versus broader-liability PGS effects, and if PGS performance varied between consumption versus pathological use.MethodsLatent growth curve models with structured residuals were used to assess the predictive utility of drinks per week and regular smoking PGS for measures of alcohol and nicotine consumption and problematic use from age 14 to 34. PGSs were generated from the largest discovery sample for alcohol and nicotine use to date (i.e., GSCAN), and examined for associations with alcohol and nicotine use in the Minnesota Twin Family Study (N=3225).ResultsThe drinking PGS was a significant predictor of age 14 problematic alcohol use and increases in problematic use during young adulthood. The smoking PGS was a significant predictor for all nicotine use outcomes. After adjusting for the effects of both PGSs, the smoking PGS demonstrated incremental predictive utility for most alcohol use outcomes and remained a significant predictor of nicotine use trajectories.ConclusionsHigher PGS for drinking and smoking were associated with more problematic levels of substance use longitudinally. The smoking PGS seems to capture both nicotine-specific and non-specific genetic liability for substance use, and may index genetic risk for broader externalizing behavior. Validation of PGS within longitudinal designs may have important clinical implications should future studies support the clinical utility of PGS for substance use disorders.

scholarly journals Accelerated alcohol use across adolescence predicts early adult symptoms of alcohol use disorder via reward-related neural function

2018 ◽  
Vol 49 (4) ◽  
pp. 675-684 ◽  
Author(s):  
Rebecca Waller ◽  
Laura Murray ◽  
Daniel S. Shaw ◽  
Erika E. Forbes ◽  
Luke W. Hyde
Keyword(s):  
Alcohol Use ◽  
Low Income ◽  
Alcohol Use Disorder ◽  
Early Adulthood ◽  
Region Of Interest ◽  
Neural Function ◽  
Psychiatric Interview ◽  
Adolescent Alcohol Use ◽  
Adolescent Alcohol ◽  
Reward Anticipation

AbstractBackgroundAlcohol use is commonly initiated during adolescence, with earlier onset known to increase the risk for alcohol use disorder (AUD). Altered function in neural reward circuitry is thought to increase the risk for AUD. To test the hypothesis that adolescent alcohol misuse primes the brain for alcohol-related psychopathology in early adulthood, we examined whether adolescent alcohol consumption rates predicted reward responsivity in the ventral striatum (VS), and in turn, AUD symptoms in adulthood.MethodsA total of 139 low income, racially diverse urban males reported on their alcohol use at ages 11, 12, 15, and 17; completed self-reports of personality, psychiatric interviews, and a functional magnetic resonance imaging (fMRI) scan at age 20; and completed a psychiatric interview at age 22. We measured adolescent alcohol use trajectories using latent growth curve modeling and measured neural responses to monetary reward using a VS region of interest. We tested indirect effects of adolescent alcohol use on AUD symptoms at age 22 via VS reward-related reactivity at age 20.ResultsGreater acceleration in adolescent alcohol use predicted increased VS response during reward anticipation at age 20. VS reactivity to reward anticipation at age 20 predicted AUD symptoms at age 22, over and above concurrent symptoms. Accelerated adolescent alcohol use predicted AUD symptoms in early adulthood via greater VS reactivity to reward anticipation.ConclusionsProspective findings support a pathway through which adolescent alcohol use increases the risk for AUD in early adulthood by impacting reward-related neural functioning. These results highlight increased VS reward-related reactivity as a biomarker for AUD vulnerability.

Relation of attachment style to family history of alcoholism and alcohol use disorders in early adulthood

2004 ◽  
Vol 75 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Martha Vungkhanching ◽  
Kenneth J Sher ◽  
Kristina M Jackson ◽  
Gilbert R Parra
Keyword(s):  
Family History ◽  
Alcohol Use ◽  
Attachment Style ◽  
Early Adulthood ◽  
Alcohol Use Disorders ◽  
History Of

Romantic relationships and alcohol use: A long-term, developmental perspective

2016 ◽  
Vol 28 (3) ◽  
pp. 773-789 ◽  
Author(s):  
Amy J. Rauer ◽  
Gregory S. Pettit ◽  
Diana R. Samek ◽  
Jennifer E. Lansford ◽  
Kenneth A. Dodge ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Romantic Relationships ◽  
Romantic Relationship ◽  
Early Adulthood ◽  
Development Project ◽  
Problematic Drinking ◽  
Romantic Involvement ◽  
Adolescent Alcohol Use ◽  
Adolescent Alcohol ◽  
Antecedents And Consequences

AbstractThis study considers the developmental origins of alcohol use in young adulthood. Despite substantial evidence linking committed romantic relationships to less problematic alcohol use in adulthood, the uniformity of these protective benefits across different romantic relationships is unclear. Further, the extent to which the establishment and maintenance of these romantic relationships is preceded by earlier adolescence alcohol use remains unknown. To address these gaps in the literature, the current study utilized multitiple-dimensional, multiple-informant data spanning 20 years on 585 individuals in the Child Development Project. Findings from both variable- and person-centered analyses support a progression of associations predicting adolescent alcohol use (ages 15–16), drinking, and romantic relationships in early adulthood (ages 18–25), and then problematic young adult alcohol use (age 27). Although adolescent alcohol use predicted greater romantic involvement and turnover in early adulthood, romantic involvement, but not turnover, appeared to reduce the likelihood of later problematic drinking. These findings remained robust even after accounting for a wide array of selection and socialization factors. Moreover, characteristics of the individuals (e.g., gender) and of their romantic relationships (e.g., partner substance use problems and romantic relationship satisfaction) did not moderate these findings. Findings underscore the importance of using a developmental–relational perspective to consider the antecedents and consequences of alcohol use early in the life span.

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