Supplemental Material for Significant Differences in Pediatric Psychotropic Side Effects: Implications for School Performance

Author(s):  
Giriyanna Gowda ◽  
Pruthvi S. ◽  
M. S. Phaneendra ◽  
Chitra Nagaraj

Background: Allergy is a common ailment affecting more than 20% of the population worldwide. Allergic patients suffer from a debilitating disease with a major impact on their quality of life, work and school performance. Allergic disorders can be debilitating, with a major impact on their quality of life, work and school performance. AIT (Allergen immunotherapy), modify the natural history of allergic disease and prevent the progression of allergic respiratory diseases by maintaining a long-lasting effect. Since the awareness among medical practitioners plays very important role in advising AIT for allergy patients, we attempted to conduct this study.Methods: This was a descriptive study done for a period of three months from December 2016 to February 2017. The 110 study subjects were recruited through purposive sampling. Doctors of various specialties and general practitioners were interviewed using self-administered, semi-structured questionnaire.Results: There were 73 (66.36%) males and 37 (33.64%) females. Mean age of the medical practitioners was 35.73±13.07 (Mean±SD). 98 (89.09%) of the practitioners were aware of skin prick test for the diagnosis of allergy, 70 (63.3%) subjects had heard term AIT, 59 (84.28%) were aware about subcutaneous immunotherapy (SCIT) and 25 (35.71%) of sublingual immunotherapy (SLIT). Forty-four (62.96%) were not advising immunotherapy for their patients in spite of having awareness on immunotherapy. The common reasons for not advising immunotherapy were long duration of treatment, high cost, less effective, not available in India, fear of side effects and others.Conclusions: Though the awareness among medical practitioners on AIT was good, majority are not advising because of long duration of treatment, high cost, less effective, not available in India, fear of side effects and others.


2012 ◽  
Vol 27 (1) ◽  
pp. 4-28 ◽  
Author(s):  
Thomas Kubiszyn ◽  
Sarah Mire ◽  
Sonia Dutt ◽  
Katina Papathopoulos ◽  
Andrea Backsheider Burridge

Author(s):  
S.K. Aggarwal ◽  
J. San Antonio

Cisplatin (cis-dichlorodiammineplatinum(II)) a potent antitumor agent is now available for the treatment of testicular and ovarian cancers. It is however, not free from its serious side effects including nephrotoxicity, gastro intestinal toxicity, myelosuppression, and ototoxicity. Here we now report that the drug produces peculiar bloating of the stomach in rats and induces acute ulceration.Wistar-derived rats weighing 200-250 g were administered cisplatin(9 mg/kg) ip as a single dose in 0.15 M NaCl. After 3 days the animals were sacrificed by decapitation. The stomachs were removed, the contents analyzed for pepsin and acidity. The inner surface was examined with a dissecting microscope after a moderate stretching for ulcers. Affected areas were fixed and processed for routine electron microscopy and enzyme cytochemistry.The drug treated animals kept on food and water consistently showed bloating and lesions (Fig. 1) with a frequency of 6-70 ulcers in the rumen section of the stomachs.


Author(s):  
J.M. Fadool ◽  
P.J. Boyer ◽  
S.K. Aggarwal

Cisplatin (CDDP) is currently one of the most valuable antineoplastic drugs available. However, it has severe toxic side effects of which nephrotoxicity is the major dose limiting factor in its use. It induces morphological changes in the kidney with hampered urine output. The present study is an effort to determine the influence of the drug on the neurohypophysis for any antidiuretic effects on the kidney.


2012 ◽  
Vol 21 (1) ◽  
pp. 15-21
Author(s):  
Merete Bakke ◽  
Allan Bardow ◽  
Eigild Møller

Severe drooling is associated with discomfort and psychosocial problems and may constitute a health risk. A variety of different surgical and non-surgical treatments have been used to diminish drooling, some of them with little or uncertain effect and others more effective but irreversible or with side effects. Based on clinical evidence, injection with botulinum toxin (BTX) into the parotid and submandibular glands is a useful treatment option, because it is local, reversible, and with few side effects, although it has to be repeated. The mechanism of BTX is a local inhibition of acetylcholine release, which diminishes receptor-coupled secretion and results in a flow rate reduction of 25–50% for 2–7 months.


2001 ◽  
Vol 26 (1) ◽  
pp. 67-71 ◽  
Author(s):  
S. A. Ahmadi-Abhari ◽  
S. Akhondzadeh ◽  
S. M. Assadi ◽  
O. L. Shabestari ◽  
Z. M. Farzanehgan ◽  
...  

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