scholarly journals Chronic stress and a cyclic regimen of estradiol administration separately facilitate spatial memory: Relationship with hippocampal CA1 spine density and dendritic complexity.

2012 ◽  
Vol 126 (1) ◽  
pp. 142-156 ◽  
Author(s):  
Cheryl D. Conrad ◽  
Katie J. McLaughlin ◽  
Thu N. Huynh ◽  
Mariam El-Ashmawy ◽  
Michelle Sparks
Keyword(s):  
Spatial Memory ◽  
Chronic Stress ◽  
Spine Density ◽  
Hippocampal Ca1 ◽  
Dendritic Complexity

scholarly journals Amygdala-hippocampal innervation modulates stress-induced depressive-like behaviors through AMPA receptors

2021 ◽  
Vol 118 (6) ◽  
pp. e2019409118
Author(s):  
Hui Ma ◽  
Chenyang Li ◽  
Jinpeng Wang ◽  
Xiaochen Zhang ◽  
Mingyue Li ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Ampa Receptors ◽  
Psychosocial Stress ◽  
Depressive Disorders ◽  
Critical Role ◽  
Neural Mechanisms ◽  
Mild Stress ◽  
Spine Density ◽  
Animal Models Of Depression ◽  
Dendritic Complexity

Chronic stress is one of the most critical factors in the onset of depressive disorders; hence, environmental factors such as psychosocial stress are commonly used to induce depressive-​like traits in animal models of depression. Ventral CA1 (vCA1) in hippocampus and basal lateral amygdala (BLA) are critical sites during chronic stress-induced alterations in depressive subjects; however, the underlying neural mechanisms remain unclear. Here we employed chronic unpredictable mild stress (CUMS) to model depression in mice and found that the activity of the posterior BLA to vCA1 (pBLA-vCA1) innervation was markedly reduced. Mice subjected to CUMS showed reduction in dendritic complexity, spine density, and synaptosomal AMPA receptors (AMPARs). Stimulation of pBLA-vCA1 innervation via chemogenetics or administration of cannabidiol (CBD) could reverse CUMS-induced synaptosomal AMPAR decrease and efficiently alleviate depressive-like behaviors in mice. These findings demonstrate a critical role for AMPARs and CBD modulation of pBLA-vCA1 innervation in CUMS-induced depressive-like behaviors.

scholarly journals Chronic social stress-induced hyperglycemia in mice couples individual stress susceptibility to impaired spatial memory

2018 ◽  
Vol 115 (43) ◽  
pp. E10187-E10196 ◽  
Author(s):  
Michael A. van der Kooij ◽  
Tanja Jene ◽  
Giulia Treccani ◽  
Isabelle Miederer ◽  
Annika Hasch ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Spatial Memory ◽  
Chronic Stress ◽  
High Glucose ◽  
Social Stress ◽  
Cognitive Impairments ◽  
Memory Performance ◽  
Dietary Treatment ◽  
Metabolic Phenotype ◽  
The Brain

Stringent glucose demands render the brain susceptible to disturbances in the supply of this main source of energy, and chronic stress may constitute such a disruption. However, whether stress-associated cognitive impairments may arise from disturbed glucose regulation remains unclear. Here we show that chronic social defeat (CSD) stress in adult male mice induces hyperglycemia and directly affects spatial memory performance. Stressed mice developed hyperglycemia and impaired glucose metabolism peripherally as well as in the brain (demonstrated by PET and induced metabolic bioluminescence imaging), which was accompanied by hippocampus-related spatial memory impairments. Importantly, the cognitive and metabolic phenotype pertained to a subset of stressed mice and could be linked to early hyperglycemia 2 days post-CSD. Based on this criterion, ∼40% of the stressed mice had a high-glucose (glucose >150 mg/dL), stress-susceptible phenotype. The relevance of this biomarker emerges from the effects of the glucose-lowering sodium glucose cotransporter 2 inhibitor empagliflozin, because upon dietary treatment, mice identified as having high glucose demonstrated restored spatial memory and normalized glucose metabolism. Conversely, reducing glucose levels by empagliflozin in mice that did not display stress-induced hyperglycemia (resilient mice) impaired their default-intact spatial memory performance. We conclude that hyperglycemia developing early after chronic stress threatens long-term glucose homeostasis and causes spatial memory dysfunction. Our findings may explain the comorbidity between stress-related and metabolic disorders, such as depression and diabetes, and suggest that cognitive impairments in both types of disorders could originate from excessive cerebral glucose accumulation.

scholarly journals Sex and chronic stress alter delta opioid receptor distribution within rat hippocampal CA1 pyramidal cells following behavioral challenges

2020 ◽  
Vol 13 ◽  
pp. 100236
Author(s):  
Batsheva R. Rubin ◽  
Megan A. Johnson ◽  
Jared M. Berman ◽  
Ellen Goldstein ◽  
Vera Pertsovskaya ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Chronic Stress ◽  
Pyramidal Cells ◽  
Delta Opioid Receptor ◽  
Behavioral Challenges ◽  
Ca1 Pyramidal Cells ◽  
Hippocampal Ca1 ◽  
Receptor Distribution

scholarly journals 7,8-Dihydroxyflavone, a Small Molecule TrkB Agonist, Improves Spatial Memory and Increases Thin Spine Density in a Mouse Model of Alzheimer Disease-Like Neuronal Loss

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e91453 ◽  
Author(s):  
Nicholas A. Castello ◽  
Michael H. Nguyen ◽  
Jenny D. Tran ◽  
David Cheng ◽  
Kim N. Green ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Mouse Model ◽  
Spatial Memory ◽  
Small Molecule ◽  
Neuronal Loss ◽  
Spine Density

scholarly journals Chronic stress impairs spatial memory and motivation for reward without disrupting motor ability and motivation to explore.

2006 ◽  
Vol 120 (4) ◽  
pp. 842-851 ◽  
Author(s):  
Jonathan K. Kleen ◽  
Matthew T. Sitomer ◽  
Peter R. Killeen ◽  
Cheryl D. Conrad
Keyword(s):  
Spatial Memory ◽  
Chronic Stress ◽  
Motor Ability
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