Is the apolipoprotein e genotype a biomarker for mild cognitive impairment? Findings from a nationally representative study.

2011 ◽  
Vol 25 (6) ◽  
pp. 679-689 ◽  
Author(s):  
Charles J. Brainerd ◽  
Valerie F. Reyna ◽  
Ronald C. Petersen ◽  
Glenn E. Smith ◽  
Emily S. Taub
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Apolipoprotein E ◽  
Representative Study ◽  
Nationally Representative ◽  
Apolipoprotein E Genotype ◽  
Genotype A

Machine Learning for the Prediction of Amyloid Positivity in Amnestic Mild Cognitive Impairment

2021 ◽  
pp. 1-15
Author(s):  
Sung Hoon Kang ◽  
Bo Kyoung Cheon ◽  
Ji-Sun Kim ◽  
Hyemin Jang ◽  
Hee Jin Kim ◽  
...  
Keyword(s):  
Machine Learning ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Apolipoprotein E ◽  
Cross Validation ◽  
Good Accuracy ◽  
External Validation ◽  
Amnestic Mild Cognitive Impairment ◽  
Temporal Region ◽  
Apolipoprotein E Genotype

Background: Amyloid (Aβ) evaluation in amnestic mild cognitive impairment (aMCI) patients is important for predicting conversion to Alzheimer’s disease. However, Aβ evaluation through amyloid positron emission tomography (PET) is limited due to high cost and safety issues. Objective: We therefore aimed to develop and validate prediction models of Aβ positivity for aMCI using optimal interpretable machine learning (ML) approaches utilizing multimodal markers. Methods: We recruited 529 aMCI patients from multiple centers who underwent Aβ PET. We trained ML algorithms using a training cohort (324 aMCI from Samsung medical center) with two-phase modelling: model 1 included age, gender, education, diabetes, hypertension, apolipoprotein E genotype, and neuropsychological test scores; model 2 included the same variables as model 1 with additional MRI features. We used four-fold cross-validation during the modelling and evaluated the models on an external validation cohort (187 aMCI from the other centers). Results: Model 1 showed good accuracy (area under the receiver operating characteristic curve [AUROC] 0.837) in cross-validation, and fair accuracy (AUROC 0.765) in external validation. Model 2 led to improvement in the prediction performance with good accuracy (AUROC 0.892) in cross validation compared to model 1. Apolipoprotein E genotype, delayed recall task scores, and interaction between cortical thickness in the temporal region and hippocampal volume were the most important predictors of Aβ positivity. Conclusion: Our results suggest that ML models are effective in predicting Aβ positivity at the individual level and could help the biomarker-guided diagnosis of prodromal AD.

Apolipoprotein E genotype and physical function among older people with mild cognitive impairment

2014 ◽  
Vol 15 (4) ◽  
pp. 422-427 ◽  
Author(s):  
Takehiko Doi ◽  
Hiroyuki Shimada ◽  
Hyuma Makizako ◽  
Kota Tsutsumimoto ◽  
Kazuki Uemura ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Older People ◽  
Apolipoprotein E ◽  
Physical Function ◽  
Apolipoprotein E Genotype

[P4-157]: CSF BIOMARKERS AND EFFECT OF APOLIPOPROTEIN E GENOTYPE, AGE AND SEX ON CUT-OFF DERIVATION IN MILD COGNITIVE IMPAIRMENT

2017 ◽  
Vol 13 (7S_Part_27) ◽  
pp. P1319-P1319 ◽  
Author(s):  
Moira Marizzoni ◽  
Clarissa Ferrari ◽  
Samantha Galluzzi ◽  
Jorge Jovicich ◽  
Diego Albani ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Apolipoprotein E ◽  
Csf Biomarkers ◽  
Apolipoprotein E Genotype ◽  
Age And Sex

scholarly journals Depression, Apolipoprotein E Genotype, and the Incidence of Mild Cognitive Impairment

2006 ◽  
Vol 63 (3) ◽  
pp. 435 ◽  
Author(s):  
Yonas E. Geda ◽  
David S. Knopman ◽  
David A. Mrazek ◽  
Gregory A. Jicha ◽  
Glenn E. Smith ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Apolipoprotein E ◽  
Apolipoprotein E Genotype

Apolipoprotein E Genotype and Cerebrovascular Alterations Can Influence Conversion to Dementia in Patients with Mild Cognitive Impairment

2014 ◽  
Vol 41 (2) ◽  
pp. 401-410 ◽  
Author(s):  
Giovanna Viticchi ◽  
Lorenzo Falsetti ◽  
Fabrizio Vernieri ◽  
Claudia Altamura ◽  
Riccardo Altavilla ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Apolipoprotein E ◽  
Apolipoprotein E Genotype
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