Examining the nature of impairment in visual paired associate learning in amnestic mild cognitive impairment.

2011 ◽  
Vol 25 (6) ◽  
pp. 752-762 ◽  
Author(s):  
Brian T. Harel ◽  
David Darby ◽  
Robert H. Pietrzak ◽  
Kathryn A. Ellis ◽  
Peter J. Snyder ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Paired Associate ◽  
Paired Associate Learning ◽  
Amnestic Mild Cognitive Impairment ◽  
Associate Learning

P3-193: Stability of amnestic mild cognitive impairment: Cantab paired associate learning as a predictor of a consistent diagnosis

2015 ◽  
Vol 11 (7S_Part_15) ◽  
pp. P706-P706
Author(s):  
Francesca K. Cormack ◽  
Jennifer H. Barnett ◽  
Pradeep Nathan ◽  
Andrew Blackwell ◽  
Shannon Z. Klekociuk ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Paired Associate ◽  
Paired Associate Learning ◽  
Amnestic Mild Cognitive Impairment ◽  
Associate Learning

scholarly journals Novel Face-Name Paired Associate Learning and Famous Face Recognition in Mild Cognitive Impairment: A Neuropsychological and Brain Volumetric Study

2019 ◽  
Vol 9 (1) ◽  
pp. 114-128
Author(s):  
Satyan Nanda ◽  
Nandini Mohanan ◽  
Sheela Kumari ◽  
Mridula Mathew ◽  
Sushama Ramachandran ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Face Recognition ◽  
Mild Cognitive Impairment ◽  
Free Recall ◽  
Associative Learning ◽  
Paired Associate ◽  
Early Stage ◽  
Paired Associate Learning ◽  
Associate Learning ◽  
Association Learning

Purpose: To assess visual associative learning and famous face recognition ability among subjects with stable amnestic mild cognitive impairment (MCI) relative to early stage dementia due to Alzheimer’s disease (AD) and cognitively normal healthy controls (NC) and to correlate these differences with volumetric changes on MRI. Methods: A hospital-based cross-sectional observational study was conducted on 61 participants. The subjects underwent neuropsychological evaluation, including validated newly designed tests for novel face-name paired association learning recall and famous face recognition. MRI volumetry was done on a subset of patients to ascertain the topographical patterns of volume loss. Results: There were significant differences in performance on free recall for face-name paired associate learning in MCI (n = 22) compared to NC (n = 20) (p < 0.001) and MCI compared to AD (n = 19; p < 0.001). Significant differences were also noted in scores on the famous personalities test between MCI and NC (p = 0.007), and MCI and AD (p = 0.032). The free recall component of face-name pair associative learning significantly correlated with left cuneus (p = 0.005; r = 0.833) and right cuneus (p = 0.003; r = 0.861) volume in AD with no significant correlation among MCI and NC cohorts. Conclusions: Novel and semantically familiar face-name associative recalls are significantly impaired in MCI, and these potentially predate the MRI volumetric changes in MCI. Our findings expand the spectrum of recall deficits in MCI.

scholarly journals Effects of nicotinic cholinergic system manipulations on paired-associate learning (PAL) in mice

SURG Journal ◽  
2014 ◽  
Vol 7 (1) ◽  
pp. 33-46
Author(s):  
Melissa Milanovic
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Task Performance ◽  
Nicotinic Receptor ◽  
Cholinergic System ◽  
Paired Associate ◽  
Paired Associate Learning ◽  
Associate Learning ◽  
Future Drug

Rationale: The ability to perform on the Cambridge Neuropsychological Test Automated Battery touchscreen paired-associate learning (PAL) test is predictive of Alzheimer’s disease and Mild Cognitive Impairment. Recently, an automated computer touchscreen PAL task for mice has been developed. Pharmacological validation of this task is warranted to establish it as a useful tool in future drug discovery pertaining to Alzheimer’s disease and Mild Cognitive Impairment. Objectives: This investigation provides a systematic analysis of nicotinic involvement within the PAL task for mice. Particularly, the effects of systemic administration of nicotinic cholinergic agents (agonist and antagonist) on PAL task performance in C57BL/6 mice were investigated. This was done to detect whether bidirectional modification of performance is consequent upon these manipulations. Methods: Upon acquiring the PAL task, nicotine (nicotinic receptor agonist; 0.1, 0.5, and 1.0 mg/kg) and mecamylamine (nicotinic receptor antagonist; 0.3, 1.0, and 3.0 mg/kg) were administered intraperitoneally to the mice in a within-subjects design, prior to daily sessions in the PAL task. Results: Nicotine did not have any significant effect on PAL performance improvement at any doses. However, mecamylamine did increase perseverative responding and reaction time in the mice. Such impairment effects are interpreted as being attentional in nature. Conclusion: This investigation indicates that mice indeed acquire the rodent PAL task, deeming it a valuable tool for future drug discovery. Further, the nicotinic cholinergic system appears to be implicated in PAL task performance, with greater effects seen with deactivation rather than activation of the system, and with these effects appearing to be of an attentional nature. Keywords: paired-associate learning (PAL); Alzheimer’s disease; nicotinic cholingeric system; touchscreen

Reactivity of Judgments of Learning in a Levels-of-Processing Paradigm

2020 ◽  
Vol 228 (4) ◽  
pp. 278-290 ◽  
Author(s):  
Eylul Tekin ◽  
Henry L. Roediger
Keyword(s):  
Target Word ◽  
Paired Associate ◽  
Judgments Of Learning ◽  
Paired Associate Learning ◽  
Levels Of Processing ◽  
Pleasantness Rating ◽  
Associate Learning ◽  
Counting Task ◽  
Reactive Effect ◽  
Target Words

Abstract. Recent studies have shown that judgments of learning (JOLs) are reactive measures in paired-associate learning paradigms. However, evidence is scarce concerning whether JOLs are reactive in other paradigms. In old/new recognition experiments, we investigated the reactivity effects of JOLs in a levels-of-processing (LOP) paradigm. In Experiments 1 and 2, for each word, subjects saw a yes/no orienting question followed by the target word and a response. Then, they either did or did not make a JOL. The yes/no questions were about target words’ appearances, rhyming properties, or category memberships. In Experiment 3, for each word, subjects gave a pleasantness rating or counted the letter “e ”. Our results revealed that JOLs enhanced recognition across all orienting tasks in Experiments 1 and 2, and for the e-counting task in Experiment 3. This reactive effect was salient for shallow tasks, attenuating – but not eliminating – the LOP effect after making JOLs. We conclude that JOLs are reactive in LOP paradigms and subjects encode words more effectively when providing JOLs.

Age, pacing, and imagery in paired-associate learning.

1976 ◽  
Vol 12 (2) ◽  
pp. 119-124 ◽  
Author(s):  
Nancy J. Treat ◽  
Hayne W. Reese
Keyword(s):  
Paired Associate ◽  
Paired Associate Learning ◽  
Associate Learning
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