Fos expression in the prefrontal cortex and nucleus accumbens following exposure to retrospective timing tasks.

2011 ◽  
Vol 125 (2) ◽  
pp. 202-214 ◽  
Author(s):  
L. Valencia Torres ◽  
C. M. Olarte Sánchez ◽  
S. Body ◽  
K. C. F. Fone ◽  
C. M. Bradshaw ◽  
...  
2002 ◽  
Vol 950 (1-2) ◽  
pp. 165-179 ◽  
Author(s):  
Gaël Hédou ◽  
Ana Lúcia Jongen-Rêlo ◽  
Carol A Murphy ◽  
Christian A Heidbreder ◽  
Joram Feldon

2018 ◽  
Vol 32 (8) ◽  
pp. 911-921 ◽  
Author(s):  
Kira-Elise Wilson ◽  
Sigrid Limburg ◽  
Melissa K Duggan ◽  
Adam J Lawther ◽  
Spencer J Williams ◽  
...  

Introduction: This study aimed to investigate the effects of the galanin-3 receptor antagonist, SNAP 37889, on c-Fos protein expression after cue-induced reinstatement of alcohol-seeking in the brains of alcohol-preferring rats. Methods: Eighteen alcohol-preferring rats were trained to self-administer 10% v/v ethanol in the presence of response-contingent cues, which was followed by extinction. Rats were then treated with SNAP 37889 (30 mg/kg, i.p.) or vehicle, before being tested for cue-induced reinstatement. Administration of SNAP 37889 reduced cue-induced reinstatement of ethanol-seeking behaviour. To examine the effect of SNAP 37889 and cue-induced reinstatement on neuronal activation, c-Fos expression was measured in subregions of the medial prefrontal cortex and nucleus accumbens. Results: SNAP 37889 administration increased c-Fos immunoreactivity in the nucleus accumbens shell, but was without effect in the nucleus accumbens core and the medial prefrontal cortex. Dual-label Fos/tyrosine hydroxylase immunohistochemistry was used to examine the effects of SNAP 37889 on dopamine neurons in the ventral tegmental area; however, no differences between SNAP 37889 and vehicle-treated rats were found. Conclusions: These data support previous findings of galanin-3 receptor involvement in cue-induced reinstatement of alcohol-seeking behaviour, and provide novel evidence that the ability of galanin-3 receptor antagonism to attenuate cue-induced reinstatement relates to activation of the nucleus accumbens shell.


2021 ◽  
Vol 234 ◽  
pp. 113357
Author(s):  
Joseph S. Lonstein ◽  
Thierry D. Charlier ◽  
Jodi L. Pawluski ◽  
Nadege Aigueperse ◽  
Maryse Meurisse ◽  
...  

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