scholarly journals Pregnancy rates among juvenile justice girls in two randomized controlled trials of multidimensional treatment foster care.

2009 ◽  
Vol 77 (3) ◽  
pp. 588-593 ◽  
Author(s):  
David C. R. Kerr ◽  
Leslie D. Leve ◽  
Patricia Chamberlain
Keyword(s):  
Foster Care ◽  
Juvenile Justice ◽  
Randomized Controlled Trials ◽  
Pregnancy Rates ◽  
Controlled Trials ◽  
Treatment Foster Care ◽  
Randomized Controlled ◽  
Multidimensional Treatment Foster Care

scholarly journals Progestin-Primed Ovarian Stimulation Protocol for Patients in Assisted Reproductive Technology: A Meta-Analysis of Randomized Controlled Trials

2021 ◽  
Vol 12 ◽  
Author(s):  
Shaogen Guan ◽  
Yuezhi Feng ◽  
Yonghan Huang ◽  
Jia Huang
Keyword(s):  
Randomized Controlled Trials ◽  
Ovarian Reserve ◽  
Ovarian Stimulation ◽  
Meta Analysis ◽  
Pregnancy Rates ◽  
Cochrane Library ◽  
Controlled Trials ◽  
Stimulation Protocol ◽  
Lh Surge ◽  
Randomized Controlled

ObjectivesProgestin-primed ovarian stimulation (PPOS) is a new ovarian stimulation protocol that can block the luteinizing hormone (LH) surge through progesterone instead of traditional down regulating or gonadotropin-releasing hormone (GnRH) antagonist, and in order to achieve multi-follicle recruitment. This paper aims to investigate the effectiveness of PPOS and its suitability for infertile patients with different ovarian reserve functions.MethodsWe searched published randomized controlled trials (RCTs) about PPOS on Cochrane Library, PubMed, Embase, and Web of Science. The search period spanned from January 1, 2015 to November 16, 2020. The data were extracted, and the meta-analysis was performed on ovarian stimulation as well as embryological and clinical outcomes. The outcomes were pooled by a random effects model, and the risk of heterogeneity was evaluated. Subgroup analysis was performed for different ovarian reserve patients.ResultsThe clinical pregnancy rates and live birth or ongoing pregnancy rates with the PPOS protocol were not different from those with the control group. In the diminished ovarian reserve (DOR) subgroup, the PPOS protocol had a lower rate of premature LH surge [RR = 0.03, 95% CI = 0.01 to 0.13, p < 0.001]. The PPOS protocol had a lower rate of ovarian hyperstimulation syndrome (OHSS) [RR = 0.52, 95% CI = 0.36 to 0.76, p < 0.001, I2 = 0.00%]. The secondary outcomes showed that the number of oocytes retrieved, MII oocytes, and viable embryos was higher than that of the control protocol in DOR patients [(MD = 0.33, 95% CI = 0.30 to 0.36, p < 0.001), (MD = 0.30, 95% CI = 0.27 to 0.33, p < 0.001), (MD = 0.21, 95% CI = 0.18 to 0.24, p < 0.001)] and normal ovarian reserve (NOR) patients [(MD = 1.41, 95% CI = 0.03 to 2.78, p < 0.001), (MD = 1.19, 95% CI = 0.04 to 2.35, p < 0.001), (MD = 1.01, 95% CI = 0.21 to 1.81, p = 0.01)].ConclusionThe findings suggest that PPOS is an effective ovarian stimulation protocol and is beneficial for patients with different ovarian reserve functions, which needs to be validated in more RCTs with larger samples.

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