A Challenging but Informative Text Reviewing Neuroactive Steroids and Associated Disorders

PsycCRITIQUES ◽  
2008 ◽  
Vol 53 (51) ◽  
Author(s):  
Catherine C. Price
Keyword(s):  
Neuroactive Steroids ◽  
Informative Text

‘Family Romance’ and the Oedipalization of Freudian Psychoanalysis

2020 ◽  
Vol 22 (2) ◽  
pp. 175-187
Author(s):  
Herman Westerink ◽  
Philippe Van Haute
Keyword(s):  
Object Relations ◽  
Sexual Difference ◽  
Oedipus Complex ◽  
Difference Family ◽  
Radical Theory ◽  
Freudian Psychoanalysis ◽  
Secondary Literature ◽  
Family Romance ◽  
Short Essay ◽  
Informative Text

Although Freud's ‘Family Romances’ from 1909 is hardly ever discussed at length in secondary literature, this article highlights this short essay as an important and informative text about Freud's changing perspectives on sexuality in the period in which the text was written. Given the fact that Freud, in his 1905 Three Essays, develops a radical theory of infantile sexuality as polymorphously perverse and as autoerotic pleasure, we argue that ‘Family Romances’, together with the closely related essay on infantile sexual theories (1908), paves the way for new theories of sexuality defined in terms of object relations informed by knowledge of sexual difference. ‘Family Romances’, in other words, preludes the introduction of the Oedipus complex, but also – interestingly – gives room for a Jungian view of sexuality and sexual phantasy. ‘Family Romances’ is thus a good illustration of the complex way in which Freud's theories of sexuality developed through time.

Microglial dependent protective effects of neuroactive steroids

2016 ◽  
Vol 15 (2) ◽  
pp. 242-249 ◽  
Author(s):  
Oscar Hidalgo Lanussa ◽  
Marco Ávila-Rodriguez ◽  
Luis Miguel García-Segura ◽  
Janneth González ◽  
Valentina Echeverria ◽  
...  
Keyword(s):  
Neuroactive Steroids ◽  
Protective Effects

scholarly journals Orthorexia nervosa and Instagram: exploring the Russian-speaking conversation around #opтopeкcия

2021 ◽  
Author(s):  
Yana Zemlyanskaya ◽  
Martina Valente ◽  
Elena V. Syurina
Keyword(s):  
Orthorexia Nervosa ◽  
Online Questionnaire ◽  
Level Of Evidence ◽  
Russian Speakers ◽  
Global North ◽  
Harmful Content ◽  
English Speaking ◽  
Comparative Content ◽  
The Relationship ◽  
Informative Text

AbstractThis mixed-methods study explored the conversation around orthorexia nervosa (ON) on Instagram from a Russian-speaking perspective. Two quantitative data sources were implemented; a comparative content analysis of posts tagged with #opтopeкcия (n = 234) and #orthorexia (n = 243), and an online questionnaire completed by Russian-speakers (n = 96) sharing ON-related content on Instagram. Additionally, five questionnaire participants were interviewed, four of which identified with having (had) ON. Russian-speakers who share ON-related content on Instagram are primarily female, around their late-twenties, and prefer Instagram over other platforms. They describe people with ON as obsessed with correct eating, rather than healthy or clean eating. Instagram appears to have a dual effect; it has the potential to both trigger the onset of ON and encourage recovery. Positive content encourages a healthy relationship with food, promotes intuitive eating, and spread recovery advice. Harmful content, in turn, emphasizes specific diet and beauty ideals. Russian-speaking users mainly post pictures of food, followed by largely informative text that explains what ON is, and what recovery may look like. Their reasons for posting ON-related content are to share personal experiences, support others in recovery, and raise awareness about ON. Two main target audiences were people unaware of ON and people seeking recovery support. The relationship between ON and social media is not strictly limited to the global north. Thus, it may be valuable to further investigate non-English-speaking populations currently underrepresented in ON research.Level of evidence: Level V, descriptive study.

scholarly journals Pitfalls of NMDA Receptor Modulation by Neuroactive Steroids. The Effect of Positive and Negative Modulation of NMDA Receptors in an Animal Model of Schizophrenia

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1026
Author(s):  
Kristina Holubova ◽  
Marketa Chvojkova ◽  
Barbora Hrcka Krausova ◽  
Vojtech Vyklicky ◽  
Eva Kudova ◽  
...  
Keyword(s):  
Animal Model ◽  
Nmda Receptor ◽  
Neuroactive Steroids ◽  
Stress Exposure ◽  
Mk 801 ◽  
Receptor Modulator ◽  
Receptor Modulation ◽  
Antipsychotic Effect ◽  
Response To Stress ◽  
Systemic Application

Evidence from clinical and preclinical studies implicates dysfunction of N-methyl-D-aspartate receptors (NMDARs) in schizophrenia progression and symptoms. We investigated the antipsychotic effect of two neuroactive steroids in an animal model of schizophrenia induced by systemic application of MK-801. The neuroactive steroids differ in their mechanism of action at NMDARs. MS-249 is positive, while PA-Glu is a negative allosteric NMDAR modulator. We hypothesized that the positive NMDA receptor modulator would attenuate deficits caused by MK-801 co-application more effectively than PA-Glu. The rats were tested in a battery of tests assessing spontaneous locomotion, anxiety and cognition. Contrary to our expectations, PA-Glu exhibited a superior antipsychotic effect to MS-249. The performance of MS-249-treated rats in cognitive tests differed depending on the level of stress the rats were exposed to during test sessions. In particular, with the increasing severity of stress exposure, the performance of animals worsened. Our results demonstrate that enhancement of NMDAR function may result in unspecific behavioral responses. Positive NMDAR modulation can influence other neurobiological processes besides memory formation, such as anxiety and response to stress.

scholarly journals Dehydroepiandrosterone (DHEA) Serum Levels Indicate Cerebrospinal Fluid Levels of DHEA and Estradiol (E2) in Women at Term Pregnancy

2021 ◽  
Author(s):  
Pardes Habib ◽  
Joseph Neulen ◽  
Shahin Habib ◽  
Benjamin Rösing
Keyword(s):  
Pregnant Women ◽  
Strong Correlation ◽  
Serum Levels ◽  
Neuroactive Steroids ◽  
Term Pregnancy ◽  
Serum Samples ◽  
Functional Changes ◽  
The Central Nervous System ◽  
Csf Levels ◽  
Fluid Levels

AbstractNeuroactive steroids such as dehydroepiandrosterone (DHEA), estradiol (E2), and progesterone (P4) are associated with structural and functional changes in the central nervous system (CNS). Measurement of steroid levels in the CNS compartments is restricted in accessibility. Consequently, there is only limited human data on the distributional equilibrium for steroid levels between peripheral and central compartments. While some neuroactive steroids including DHEA and E2 have been reported to convey excitatory and proconvulsant properties, the opposite was demonstrated for P4. We aimed to elucidate the correlation between peripheral and central DHEA, E2, and P4 levels in women at term pregnancy. CSF and serum samples of 27 healthy pregnant women (22–39 years) at term pregnancy were collected simultaneously under combined spinal and epidural anesthesia and used for DHEA ELISA and E2, and P4 ECLIA. All three neuroactive steroids were detected at markedly lower levels in CSF compared to their corresponding serum concentrations (decrease, mean ± SD, 97.66 ± 0.83%). We found a strong correlation for DHEA between its serum and the corresponding CSF levels (r = 0.65, p = 0.003). Serum and CSF levels of E2 (r = 0.31, p = 0.12) appeared not to correlate in the investigated cohort. DHEA serum concentration correlated significantly with E2 (r = 0.58, p = 0.0016) in CSF. In addition, a strong correlation was found between DHEA and E2, both measured in CSF (r = 0.65, p = 0.0002). Peripheral DHEA levels might serve as an indicator for central nervous levels of the neuroactive steroids DHEA and E2 in pregnant women.

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