Ultrasonic vocalizations of rats (Rattus norvegicus) during mating, play, and aggression: Behavioral concomitants, relationship to reward, and self-administration of playback..

2008 ◽  
Vol 122 (4) ◽  
pp. 357-367 ◽  
Author(s):  
Jeffrey Burgdorf ◽  
Roger A. Kroes ◽  
Joseph R. Moskal ◽  
James G. Pfaus ◽  
Stefan M. Brudzynski ◽  
...  
Keyword(s):  
Rattus Norvegicus ◽  
Ultrasonic Vocalizations ◽  
Self Administration

scholarly journals Ultrasonic vocalizations of female Norway rats (Rattus norvegicus) in response to social partners.

2016 ◽  
Vol 130 (1) ◽  
pp. 76-80 ◽  
Author(s):  
Annegret Börner ◽  
Rebecca Hjemdahl ◽  
Thomas Götz ◽  
Gillian R. Brown
Keyword(s):  
Rattus Norvegicus ◽  
Ultrasonic Vocalizations ◽  
Social Partners ◽  
Norway Rats

scholarly journals Ultrasonic vocalizations: evidence for an affective opponent process during cocaine self-administration

2013 ◽  
Vol 231 (5) ◽  
pp. 909-918 ◽  
Author(s):  
David J. Barker ◽  
Steven J. Simmons ◽  
Lisa C. Servilio ◽  
Danielle Bercovicz ◽  
Sisi Ma ◽  
...  
Keyword(s):  
Ultrasonic Vocalizations ◽  
Self Administration ◽  
Opponent Process

scholarly journals Evidence for a vocal signature in the rat and its reinforcing effects: a key role for the subthalamic nucleus

2021 ◽  
Vol 288 (1965) ◽  
Author(s):  
Cassandre Vielle ◽  
Christian Montanari ◽  
Yann Pelloux ◽  
Christelle Baunez
Keyword(s):  
Subthalamic Nucleus ◽  
Social Factors ◽  
Lever Press ◽  
Emotional Valence ◽  
Ultrasonic Vocalizations ◽  
Drug Consumption ◽  
Self Administration ◽  
Vocal Signature ◽  
Reinforcing Effects

Although rodents have a well-structured vocal form of communication, like humans and non-human primates, there is, to date, no evidence for a vocal signature in the well-known 50- and 22-kHz ultrasonic vocalizations (USVs) emitted by rats. Here, we show that rats can recognize the identity of the USV emitter since they choose to preferentially self-administer playback of 50-kHz USVs emitted by a stranger rat over those of their cagemate. In a second experiment, we show that only stranger, but not familiar, 50-kHz USVs reduce cocaine self-administration. Finally, to study the neurobiological substrate of these processes, we have shown that subthalamic nucleus (STN)-lesioned rats did not lever press much for any USV playback, whatever their emotional valence, nor did they seem able to differentiate familiar from stranger peer. Advocating for the existence of a vocal signature in rats, these results highlight the importance of ultrasonic communication in the socio-affective influence of behaviour, such as the influence of proximal social factors on drug consumption and confirm the role of the STN on this influence.

scholarly journals Role of hypocretin/orexin receptor blockade on drug-taking and ultrasonic vocalizations (USVs) associated with low-effort self-administration of cathinone-derived 3,4-methylenedioxypyrovalerone (MDPV) in rats

2017 ◽  
Vol 234 (21) ◽  
pp. 3207-3215 ◽  
Author(s):  
Steven J. Simmons ◽  
Rose Martorana ◽  
Helene Philogene-Khalid ◽  
Fionya H. Tran ◽  
Taylor A. Gentile ◽  
...  
Keyword(s):  
Ultrasonic Vocalizations ◽  
Receptor Blockade ◽  
Self Administration

scholarly journals Maternal Continuous Oral Oxycodone Self-Administration Alters Pup Affective/Social Communication but not Spatial Learning or Sensory-Motor Function

2020 ◽  
Author(s):  
Giulia Zanni ◽  
Patrese A. Robinson-Drummer ◽  
Ashlee A. Dougher ◽  
Hannah M. Deutsch ◽  
Matthew J. DeSalle ◽  
...  
Keyword(s):  
Motor Function ◽  
Spatial Learning ◽  
Social Communication ◽  
Emotional Behavior ◽  
Ultrasonic Vocalizations ◽  
Female Rats ◽  
List Type ◽  
Self Administration ◽  
Precipitated Withdrawal ◽  
And Control

AbstractThe broad use and misuse of prescription opioids during pregnancy has resulted in a surge of infants diagnosed with Neonatal Opioid Withdrawal Syndrome (NOWS). Short-term irritability and neurological complications are hallmarks of NOWS, but the long-term consequences are unknown. Our newly-developed preclinical model of oxycodone self-administration enables adult female rats to readily drink oxycodone (0.06-0.12 mg/ml, ∼10/mg/kg/day) continuously before and during pregnancy and after delivery, to achieve similar liquid intake in oxycodone moms relative to water-only controls. Oxycodone levels were detected in the serum of mothers and pups. Growth parameters in dams and pups, and litter mass and size were similar to controls. Maternal behavior at postnatal day 1 (PN1) was unchanged by perinatal oxycodone consumption. Regarding the plantar thermal response, there were no differences in paw retraction latency between oxycodone and control pups at PN2 or PN14. Oxycodone and control pups had similar motor coordination, cliff avoidance, righting time, pivoting, and olfactory spatial learning from PN3 through PN13. Separation-induced ultrasonic vocalizations at PN8 revealed higher call frequency in oxycodone pups relative to controls. Finally, during naltrexone precipitated withdrawal at PN9, oxycodone males vocalized more than control pups, consistent with a previously-published withdrawal phenotype. Thus, our rat model of continuous oral oxycodone self-administration in pregnancy shows exacerbated affect/social communication in pups in a sex-dependent manner but spared cognition and locomotion. Our preclinical, high face validity NOWS model reproduces key aspects of human opioid use during pregnancy, enabling longitudinal analysis of how maternal oxycodone changes emotional behavior in the offspring.HIGHLIGHTSFemale rats self-administered oxycodone at clinically relevant doses before and during pregnancy and for the first two weeks after parturition.Both dams and pups, for the14 day postnatal experimental period, had detectable levels of oxycodone in their bloodDams drinking oxycodone only or water only did not differ in weight gain, water intake, or the number of pups born and their pups did not differ in weight throughout.Sensory and motor function in the pups was not altered, nor was hippocampal dependent spatial learning.Oxycodone exposed pups were physically dependent and displayed increased withdrawal behaviors with or without the opioid antagonist naltrexone.Pups expressed more negative affect, expressed by increased ultrasonic vocalizations, following naltrexone precipitated withdrawal or when separated from their mother.

Ultrasonic vocalizations as indicators of welfare for laboratory rats (Rattus norvegicus)

2007 ◽  
Vol 104 (1-2) ◽  
pp. 116-129 ◽  
Author(s):  
Oliver H.P. Burman ◽  
Alexander Ilyat ◽  
Gareth Jones ◽  
Michael Mendl
Keyword(s):  
Rattus Norvegicus ◽  
Ultrasonic Vocalizations ◽  
Laboratory Rats
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