When couples cope with job loss: A strategy for developing and testing preventive interventions.

1995 ◽  
pp. 139-157 ◽  
Author(s):  
George W. Howe ◽  
Robert D. Caplan ◽  
David Foster ◽  
Mindy Lockshin ◽  
Claire McGrath
Keyword(s):  
Job Loss ◽  
Preventive Interventions

Inflammational Animal Models for Schizophrenia

2015 ◽  
Vol 223 (3) ◽  
pp. 157-164 ◽  
Author(s):  
Georg Juckel
Keyword(s):  
Animal Model ◽  
Animal Models ◽  
Immune Activation ◽  
Microglial Activation ◽  
Treatment Options ◽  
Early Adulthood ◽  
Brain Regions ◽  
Synaptic Connections ◽  
Preventive Interventions ◽  
Immunological System

Abstract. Inflammational-immunological processes within the pathophysiology of schizophrenia seem to play an important role. Early signals of neurobiological changes in the embryonal phase of brain in later patients with schizophrenia might lead to activation of the immunological system, for example, of cytokines and microglial cells. Microglia then induces – via the neurotoxic activities of these cells as an overreaction – a rarification of synaptic connections in frontal and temporal brain regions, that is, reduction of the neuropil. Promising inflammational animal models for schizophrenia with high validity can be used today to mimic behavioral as well as neurobiological findings in patients, for example, the well-known neurochemical alterations of dopaminergic, glutamatergic, serotonergic, and other neurotransmitter systems. Also the microglial activation can be modeled well within one of this models, that is, the inflammational PolyI:C animal model of schizophrenia, showing a time peak in late adolescence/early adulthood. The exact mechanism, by which activated microglia cells then triggers further neurodegeneration, must now be investigated in broader detail. Thus, these animal models can be used to understand the pathophysiology of schizophrenia better especially concerning the interaction of immune activation, inflammation, and neurodegeneration. This could also lead to the development of anti-inflammational treatment options and of preventive interventions.

Age Differences in Coping With Job Loss

2012 ◽  
Author(s):  
Erica D. Ermann ◽  
Kurt Kraiger
Keyword(s):  
Age Differences ◽  
Job Loss ◽  
Coping With Job Loss

Underlying Mechanisms in Differential Responsivity to Preventive Interventions Among Adolescents

2006 ◽  
Author(s):  
Diana H. Fishbein ◽  
Christopher Hyde ◽  
Diana Eldreth ◽  
Mallie J. Paschall ◽  
Robert Hubal ◽  
...  
Keyword(s):  
Preventive Interventions ◽  
Underlying Mechanisms
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