Model studies of advective heat flow associated with compaction and dehydration in accretionary prisms

1994 ◽  
Vol 99 (B5) ◽  
pp. 9319-9325 ◽  
Author(s):  
Yaolin Shi ◽  
Chi-Yuen Wang
1993 ◽  
Vol 20 (8) ◽  
pp. 659-662 ◽  
Author(s):  
Chi-yuen Wang ◽  
Guoping Liang ◽  
Yaolin Shi

1995 ◽  
Vol 74 (03) ◽  
pp. 868-873 ◽  
Author(s):  
Silvana Arrighi ◽  
Roberta Rossi ◽  
Maria Giuseppina Borri ◽  
Vladimir Lesnikov ◽  
Marina Lesnikov ◽  
...  

SummaryTo improve the safety of plasma derived factor VIII (FVIII) concentrate, we introduced a final super heat treatment (100° C for 30 min) as additional virus inactivation step applied to a lyophilized, highly purified FVIII concentrate (100 IU/mg of proteins) already virus inactivated using the solvent/detergent (SID) method during the manufacturing process.The efficiency of the super heat treatment was demonstrated in inactivating two non-lipid enveloped viruses (Hepatitis A virus and Poliovirus 1). The loss of FVIII procoagulant activity during the super heat treatment was of about 15%, estimated both by clotting and chromogenic assays. No substantial changes were observed in physical, biochemical and immunological characteristics of the heat treated FVIII concentrate in comparison with those of the FVIII before heat treatment.


2019 ◽  
Vol 139 (8) ◽  
pp. 258-264
Author(s):  
Hayato Tsuchiya ◽  
Yusuke Suganuma ◽  
Masanori Muroyama ◽  
Takahiro Nakayama ◽  
Yutaka Nonomura

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