Reversed polarity characteristic magnetizations in the Albian Contessa Section, Umbrian Apennines, Italy: Implications for the existence of a Mid-Cretaceous mixed polarity interval

1992 ◽  
Vol 97 (B1) ◽  
pp. 241 ◽  
Author(s):  
John A. Tarduno ◽  
William Lowrie ◽  
William V. Sliter ◽  
Timothy J. Bralower ◽  
Friedrich Heller
1961 ◽  
Vol 201 (5) ◽  
pp. 873-880 ◽  
Author(s):  
T. Hoshiko ◽  
Nick Sperelakis

In frog ventricular strips bathed in Ca-free Ringer's solution containing 6–30 mm/liter Mg and treated with conditioning current pulses, propagation became impaired. An exaggerated foot, or prepotential, was consistently more prominent when the conditioned strip was stimulated from one end than from the other. Occasionally a prepotential in isolation alternated with a prepotential plus action potential response. After further treatment with current pulses, propagation failed in the direction of negative current flow. Thresholds of impaled cells were identical. Bidirectional propagation was restored in Ringer's solution. Conditioning pulses of reversed polarity induced unidirectional propagation in the reverse direction. Propagation in frog sartorius muscle was not blocked under similar conditions. Prepotentials and unidirectional propagation may be explained by junctional transmission from cell to cell.


2021 ◽  
Vol 27 (4) ◽  
pp. 369-376
Author(s):  
Helen J. Trihia ◽  
Pavlos Lampropoulos ◽  
Loukas Karelis ◽  
Efthymia Souka ◽  
Georgios Galanopoulos ◽  
...  

2015 ◽  
Vol 16 (11) ◽  
pp. 1105-1107 ◽  
Author(s):  
Mark Peakman ◽  
Andrew K Sewell
Keyword(s):  

2011 ◽  
Vol 35 (4) ◽  
pp. 793-851 ◽  
Author(s):  
Karin Axelsson

This article proposes a new categorization of confirmation-seeking question tags, based on how the use of such tags is restricted in relation to the preceding clause, the anchor. The focus is on a category labelled grammatically-dependent question tags (GDQTs). Earlier research has claimed that almost only English has such question tags, but this article presents and compares data on GDQTs from more than ten languages, and suggests a hierarchy for features of grammatical dependence in question tags: polarity < tense < number/person < (semantic) gender (possibly also < verb substitution). The GDQT structures vary in different ways: all GDQT languages have negative GDQTs, but not all have positive GDQTs; verb substitution is not always applied and constant polarity instead of reversed polarity is also found.


Development ◽  
1985 ◽  
Vol 87 (1) ◽  
pp. 129-135
Author(s):  
Alfonso Martinez-Arias ◽  
Philip W. Ingham

Mutations of the segment polarity group in Drosophila melanogaster produce additional denticles with reversed polarity in every segment of the larval cuticle. We have investigated the effect of mutations in different elements of the bithorax complex on the segmental identity of these additional pattern elements. Our results suggest that they are derived, primarily, from the anterior compartment of each segment.


2018 ◽  
Vol 869 (2) ◽  
pp. 147 ◽  
Author(s):  
Sanjiv K. Tiwari ◽  
Ronald L. Moore ◽  
Bart De Pontieu ◽  
Theodore D. Tarbell ◽  
Navdeep K. Panesar ◽  
...  

1991 ◽  
Vol 260 (3) ◽  
pp. F420-F430 ◽  
Author(s):  
P. D. Wilson ◽  
A. C. Sherwood ◽  
K. Palla ◽  
J. Du ◽  
R. Watson ◽  
...  

Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder in which renal tubules become enormously enlarged due to fluid accumulation. Na(+) -K(+) -ATPase was compared in normal and cystic regions of whole kidneys and in confluent primary cultures of microdissected renal tubule and cyst-lining epithelia. Immunostaining with antibodies directed against the Na(+) -K(+) -ATPase catalytic alpha-subunit was confined to apical, luminal plasma membranes of ADPKD epithelia, which was a complete reversal of the normal renal tubule polarized location in basolateral membranes. Mislocated Na(+) -K(+) -ATPase was shown to be functionally active, because identical intense apical staining was observed by use of a cytochemical assay. In addition, biochemical assays showed a significant increase in these ouabain-inhibitable Na(+) -K(+) -ATPase specific activity levels in ADPKD kidneys compared with age-matched normal kidneys. Specific binding of [3H] ouabain was not only increased but also confined to the apical membrane vesicles prepared from cystic regions of ADPKD kidneys compared with normal age-matched controls, in which binding was confined to basolateral membrane vesicles. Although steady-state levels of Na(+) -K(+) -ATPase alpha- and beta-subunit in mRNAs were increased somewhat in ADPKD kidneys, this alone was not sufficient to account for the observed activation. Confluent ADPKD epithelia grown on dual-chamber, permeable membrane supports also showed reversed polarity of 22NaCl vectorial transport, because this was from basal to apical media compartments. Because this transport could also be blocked by ouabain, this suggested apical Na(+) -K(+) -ATPase was responsible and implicated altered polarity of Na(+) -K(+) -ATPase and resultant Na+ secretion as a mechanism for cyst formation in ADPKD. Because no reversal of polarity of other basolateral or apical membrane proteins was detected, an intracellular sorting defect specific for Na(+) -K(+) -ATPase is proposed.


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