scholarly journals Spatial Effects of Livestock Farming on Human Infections With Shiga Toxin‐Producing Escherichia coli O157 in Small but Densely Populated Regions: The Case of the Netherlands

GeoHealth ◽  
2020 ◽  
Vol 4 (11) ◽  
Author(s):  
A. C. Mulder ◽  
J. Kassteele ◽  
D. Heederik ◽  
R. Pijnacker ◽  
L. Mughini‐Gras ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
The Netherlands ◽  
Shiga Toxin ◽  
Escherichia Coli O157 ◽  
Spatial Effects ◽  
Livestock Farming ◽  
Human Infections

scholarly journals Disease burden in The Netherlands due to infections with Shiga toxin-producing Escherichia coli O157

2004 ◽  
Vol 132 (3) ◽  
pp. 467-484 ◽  
Author(s):  
A. H. HAVELAAR ◽  
Y. T. H. P. VAN DUYNHOVEN ◽  
M. J. NAUTA ◽  
M. BOUWKNEGT ◽  
A. E. HEUVELINK ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
The Netherlands ◽  
Shiga Toxin ◽  
Disease Burden ◽  
Escherichia Coli O157

scholarly journals Whole-Genome Sequencing Applied to the Molecular Epidemiology of Shiga Toxin-Producing Escherichia coli O157:H7 in Argentina: TABLE 1 

2016 ◽  
Vol 4 (6) ◽  
Author(s):  
Claudia Carolina Carbonari ◽  
Nahuel Fittipaldi ◽  
Sarah Teatero ◽  
Taryn B. T. Athey ◽  
Luis Pianciola ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Molecular Epidemiology ◽  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Shiga Toxin ◽  
Whole Genome ◽  
Escherichia Coli O157 ◽  
Genome Sequences ◽  
High Quality ◽  
Human Infections

Shiga toxin-producing Escherichia coli strains are worldwide associated with sporadic human infections and outbreaks. In this work, we report the availability of high-quality draft whole-genome sequences for 19 O157:H7 strains isolated in Argentina.

Enhanced Laboratory-Based Surveillance of Shiga-Toxin-Producing Escherichia coli O157 in The Netherlands

2002 ◽  
Vol 21 (7) ◽  
pp. 513-522 ◽  
Author(s):  
Y. van Duynhoven ◽  
C. de Jager ◽  
Heuvelink A. ◽  
W. van der Zwaluw ◽  
Maas H. ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
The Netherlands ◽  
Shiga Toxin ◽  
Escherichia Coli O157

Cost of Illness and Disease Burden in The Netherlands Due to Infections with Shiga Toxin–Producing Escherichia coli O157

2011 ◽  
Vol 74 (4) ◽  
pp. 545-552 ◽  
Author(s):  
LUQMAN TARIQ ◽  
JUANITA HAAGSMA ◽  
ARIE HAVELAAR
Keyword(s):  
Escherichia Coli ◽  
Health Care ◽  
The Netherlands ◽  
Health Care Costs ◽  
Cost Of Illness ◽  
Shiga Toxin ◽  
Disease Burden ◽  
Escherichia Coli O157 ◽  
Discounted Costs ◽  
Care Costs

Infections with Shiga toxin–producing Escherichia coli O157 (STEC O157) are associated with hemorrhagic colitis, hemolytic uremic syndrome (HUS), and end-stage renal disease (ESRD). In the present study, we extend previous estimates of the burden of disease associated with STEC O157 with estimates of the associated cost of illness in The Netherlands. A second-order stochastic simulation model was used to calculate disease burden as disability-adjusted life years (DALYs) and cost of illness (including direct health care costs and indirect non–health care costs). Future burden and costs are presented undiscounted and discounted at annual percentages of 1.5 and 4%, respectively. Annually, approximately 2.100 persons per year experience symptoms of gastroenteritis, leading to 22 cases of HUS and 3 cases of ESRD. The disease burden at the population level was estimated at 133 DALYs (87 DALYs discounted) per year. Total annual undiscounted and discounted costs of illness due to STEC O157 infection for the Dutch society were estimated at €9.1 million and €4.5 million, respectively. Average lifetime undiscounted and discounted costs per case were both €126 for diarrheal illness, both €25,713 for HUS, and €2.76 million and €1.22 million, respectively, for ESRD. The undiscounted and discounted costs per case of diarrheal disease including sequelae were €4,132 and €2,131 , respectively. Compared with other foodborne pathogens, STEC O157 infections result in relatively low burden and low annual costs at the societal level, but the burden and costs per case are high.

scholarly journals Emergence of Escherichia coli encoding Shiga toxin 2f in human Shiga toxin-producing E. coli (STEC) infections in the Netherlands, January 2008 to December 2011

2014 ◽  
Vol 19 (17) ◽  
Author(s):  
I Friesema ◽  
K van der Zwaluw ◽  
T Schuurman ◽  
M Kooistra-Smid ◽  
E Franz ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
The Netherlands ◽  
Shiga Toxin ◽  
Distinct Group ◽  
Shiga Toxins ◽  
E Coli ◽  
Mild Disease ◽  
Shiga Toxin 2 ◽  
Almost All ◽  
Human Infections

The Shiga toxins of Shiga toxin-producing Escherichia coli (STEC) can be divided into Shiga toxin 1 (Stx1) and Shiga toxin 2 (Stx2) with several sub-variants. Variant Stx2f is one of the latest described, but has been rarely associated with symptomatic human infections. In the enhanced STEC surveillance in the Netherlands, 198 STEC O157 cases and 351 STEC non-O157 cases, including 87 stx2f STEC isolates, were reported between 2008 and 2011. Most stx2f strains belonged to the serogroups O63:H6 (n=47, 54%), O113:H6 (n=12, 14%) and O125:H6 (n=12, 14%). Of the 87 stx2f isolates, 84 (97%) harboured the E. coli attaching and effacing (eae) gene, but not the enterohaemorrhagic E. coli haemolysin (hly) gene. Stx2f STEC infections show milder symptoms and a less severe clinical course than STEC O157 infections. Almost all infections with stx2f (n=83, 95%) occurred between June and December, compared to 170/198 (86%) of STEC O157 and 173/264 (66%) of other STEC non-O157. Stx2f STEC infections in the Netherlands are more common than anticipated, and form a distinct group within STEC with regard to virulence genes and the relatively mild disease.

scholarly journals Epidemiology of Shiga Toxin-Producing Escherichia coli O157 in the Province of Alberta, Canada, 2009–2016

Toxins ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 613 ◽  
Author(s):  
Lisboa ◽  
Szelewicki ◽  
Lin ◽  
Latonas ◽  
Li ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Shiga Toxin ◽  
Rural Areas ◽  
One Health ◽  
Escherichia Coli O157 ◽  
Urban Centers ◽  
Uremic Syndrome ◽  
Human Infections ◽  
Made In ◽  
Marked Drop

Shiga toxin-producing Escherichia coli (STEC) infections are the product of the interaction between bacteria, phages, animals, humans, and the environment. In the late 1980s, Alberta had one of the highest incidences of STEC infections in North America. Herein, we revisit and contextualize the epidemiology of STEC O157 human infections in Alberta for the period 2009–2016. STEC O157 infections were concentrated in large urban centers, but also in rural areas with high cattle density. Hospitalization was often required when the Shiga toxin genotype stx2a stx2c was involved, however, only those aged 60 years or older and infection during spring months (April to June) independently predicted that need. Since the late 1980s, the rate of STEC O157-associated hemolytic uremic syndrome (HUS) in Alberta has remained unchanged at 5.1%, despite a marked drop in the overall incidence of the infection. While Shiga toxin genotypes stx1a stx2c and stx2a stx2c seemed associated with HUS, only those aged under 10 years and infection during spring months were independently predictive of that complication. The complexity of the current epidemiology of STEC O157 in Alberta highlights the need for a One Health approach for further progress to be made in mitigating STEC morbidity.

scholarly journals Genetic Features Differentiating Bovine, Food, and Human Isolates of Shiga Toxin-Producing Escherichia coli O157 in The Netherlands

2011 ◽  
Vol 50 (3) ◽  
pp. 772-780 ◽  
Author(s):  
E. Franz ◽  
A. H. A. M. van Hoek ◽  
F. J. van der Wal ◽  
A. de Boer ◽  
A. Zwartkruis-Nahuis ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
The Netherlands ◽  
Shiga Toxin ◽  
Escherichia Coli O157 ◽  
Genetic Features

scholarly journals An international outbreak of Shiga toxin-producing Escherichia coli O157 infection due to lettuce, September – October 2007

2008 ◽  
Vol 13 (50) ◽  
Author(s):  
I Friesema ◽  
G Sigmundsdottir ◽  
K van der Zwaluw ◽  
A Heuvelink ◽  
B Schimmer ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
The Netherlands ◽  
Shiga Toxin ◽  
Food Processing ◽  
Processing Plant ◽  
Surveillance Systems ◽  
Escherichia Coli O157 ◽  
Food Borne ◽  
Processing Plants ◽  
Epidemiological Link

Between 14 September and 20 October 2007, an outbreak of Shiga toxin-producing Escherichia coli (STEC) O157 simultaneously occurred in the Netherlands and Iceland. A total of 50 laboratory-confirmed cases were reported with a STEC O157 infection caused by the same clone. The strain was of type O157:H-, PT8, positive for stx1, stx2, eae and e-hly, and sorbitol negative. The most probable cause of this international outbreak was contaminated lettuce, shredded and pre-packed in a Dutch food processing plant. Samples of the environment, raw produce and end products, taken at several vegetable growers and processing plants all tested negative for STEC O157. However, the only epidemiological link between the cases in the Netherlands and in Iceland was the implicated Dutch processing plant. In Europe, food products are often widely distributed posing the risk of potential spread of food borne pathogens simultaneously to several countries. This international outbreak emphasises the importance of common alert and surveillance systems in earlier detection of international outbreaks and better assessment of their spread.

scholarly journals Pathogenic Potential of Emergent Sorbitol-Fermenting Escherichia coli O157:NM

2008 ◽  
Vol 76 (12) ◽  
pp. 5598-5607 ◽  
Author(s):  
Tracy Rosser ◽  
Tracy Dransfield ◽  
Lesley Allison ◽  
Mary Hanson ◽  
Nicola Holden ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Shiga Toxin ◽  
Human Infection ◽  
Escherichia Coli O157 ◽  
Pathogenic Potential ◽  
E Coli ◽  
Toxin Exposure ◽  
Uremic Syndrome ◽  
Human Infections ◽  
Main Factor

ABSTRACT Non-sorbitol-fermenting (NSF) Escherichia coli O157:H7 is the primary Shiga toxin-producing E. coli (STEC) serotype associated with human infection. Since 1988, sorbitol-fermenting (SF) STEC O157:NM strains have emerged and have been associated with a higher incidence of progression to hemolytic-uremic syndrome (HUS) than NSF STEC O157:H7. This study investigated bacterial factors that may account for the increased pathogenic potential of SF STEC O157:NM. While no evidence of toxin or toxin expression differences between the two O157 groups was found, the SF STEC O157:NM strains adhered at significantly higher levels to a human colonic cell line. Under the conditions tested, curli were shown to be the main factor responsible for the increased adherence to Caco-2 cells. Notably, 52 of 66 (79%) European SF STEC O157:NM strains tested bound Congo red at 37οC and this correlated with curli expression. In a subset of strains, curli expression was due to increased expression from the csgBAC promoter that was not always a consequence of increased csgD expression. The capacity of SF STEC O157:NM strains to express curli at 37οC may have relevance to the epidemiology of human infections as curliated strains could promote higher levels of colonization and inflammation in the human intestine. In turn, this could lead to increased toxin exposure and an increased likelihood of progression to HUS.

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