An inversion method to analyze rupture processes of small earthquakes using stopping phases

2002 ◽  
Vol 107 (B3) ◽  
Author(s):  
Kazutoshi Imanishi
Keyword(s):  
Inversion Method ◽  
Stopping Phases

Formulation, Design and Development of Niosome Based Topical Gel for Skin Cancer

2017 ◽  
Vol 2 (3) ◽  
Keyword(s):  
Skin Cancer ◽  
Drug Release ◽  
Hemorrhagic Cystitis ◽  
The Body ◽  
Cancer Drug ◽  
Inversion Method ◽  
Body Parts ◽  
Basal Cells ◽  
Formulation Design ◽  
Topical Gel

Melanoma is the most dangerous type of skin cancer in which mostly damaged unpaired DNA starts mutating abnormally and staged an unprecedented proliferation of epithelial skin to form a malignant tumor. In epidemics of skin, pigment-forming melanocytes of basal cells start depleting and form uneven black or brown moles. Melanoma can further spread all over the body parts and could become hard to detect. In USA Melanoma kills an estimated 10,130 people annually. This challenge can be succumbed by using the certain anti-cancer drug. In this study design, cyclophosphamide were used as a model drug. But it has own limitation like mild to moderate use may cause severe cytopenia, hemorrhagic cystitis, neutropenia, alopecia and GI disturbance. This is a promising challenge, which is caused due to the increasing in plasma drug concentration above therapeutic level and due to no rate limiting steps involved in formulation design. In this study, we tried to modify drug release up to threefold and extended the release of drug by preparing and designing niosome based topical gel. In the presence of Dichloromethane, Span60 and cholesterol, the initial niosomes were prepared using vacuum evaporator. The optimum percentage drug entrapment efficacy, zeta potential, particle size was found to be 72.16%, 6.19mV, 1.67µm.Prepared niosomes were further characterized using TEM analyzer. The optimum batch of niosomes was selected and incorporated into topical gel preparation. Cold inversion method and Poloxamer -188 and HPMC as core polymers, were used to prepare cyclophosphamide niosome based topical gel. The formula was designed using Design expert 7.0.0 software and Box-Behnken Design model was selected. Almost all the evaluation parameters were studied and reported. The MTT shows good % cell growth inhibition by prepared niosome based gel against of A375 cell line. The drug release was extended up to 20th hours. Further as per ICH Q1A (R2), guideline 6 month stability studies were performed. The results were satisfactory and indicating a good formulation approach design was achieved for Melanoma treatment.

scholarly journals Imaging the subsurface using induced seismicity and ambient noise: 3-D tomographic Monte Carlo joint inversion of earthquake body wave traveltimes and surface wave dispersion

2020 ◽  
Vol 222 (3) ◽  
pp. 1639-1655
Author(s):  
Xin Zhang ◽  
Corinna Roy ◽  
Andrew Curtis ◽  
Andy Nowacki ◽  
Brian Baptie
Keyword(s):  
Surface Wave ◽  
Ambient Noise ◽  
Velocity Structure ◽  
Joint Inversion ◽  
Body Wave ◽  
Source Parameters ◽  
Wave Dispersion ◽  
Inversion Method ◽  
Surface Wave Dispersion ◽  
Wave Data

SUMMARY Seismic body wave traveltime tomography and surface wave dispersion tomography have been used widely to characterize earthquakes and to study the subsurface structure of the Earth. Since these types of problem are often significantly non-linear and have non-unique solutions, Markov chain Monte Carlo methods have been used to find probabilistic solutions. Body and surface wave data are usually inverted separately to produce independent velocity models. However, body wave tomography is generally sensitive to structure around the subvolume in which earthquakes occur and produces limited resolution in the shallower Earth, whereas surface wave tomography is often sensitive to shallower structure. To better estimate subsurface properties, we therefore jointly invert for the seismic velocity structure and earthquake locations using body and surface wave data simultaneously. We apply the new joint inversion method to a mining site in the United Kingdom at which induced seismicity occurred and was recorded on a small local network of stations, and where ambient noise recordings are available from the same stations. The ambient noise is processed to obtain inter-receiver surface wave dispersion measurements which are inverted jointly with body wave arrival times from local earthquakes. The results show that by using both types of data, the earthquake source parameters and the velocity structure can be better constrained than in independent inversions. To further understand and interpret the results, we conduct synthetic tests to compare the results from body wave inversion and joint inversion. The results show that trade-offs between source parameters and velocities appear to bias results if only body wave data are used, but this issue is largely resolved by using the joint inversion method. Thus the use of ambient seismic noise and our fully non-linear inversion provides a valuable, improved method to image the subsurface velocity and seismicity.

First-arrival traveltime inversion of seismic diving waves observed on undulant surface

2021 ◽  
Vol 225 (2) ◽  
pp. 1020-1031
Author(s):  
Huachen Yang ◽  
Jianzhong Zhang ◽  
Kai Ren ◽  
Changbo Wang
Keyword(s):  
Turning Points ◽  
Analytical Formula ◽  
Velocity Model ◽  
Western China ◽  
Inversion Method ◽  
Mountain Area ◽  
Traveltime Inversion ◽  
Static Correction ◽  
Velocity Models ◽  
First Arrival

SUMMARY A non-iterative first-arrival traveltime inversion method (NFTI) is proposed for building smooth velocity models using seismic diving waves observed on irregular surface. The new ray and traveltime equations of diving waves propagating in smooth media with undulant observation surface are deduced. According to the proposed ray and traveltime equations, an analytical formula for determining the location of the diving-wave turning points is then derived. Taking the influence of rough topography on first-arrival traveltimes into account, the new equations for calculating the velocities at turning points are established. Based on these equations, a method is proposed to construct subsurface velocity models from the observation surface downward to the bottom using the first-arrival traveltimes in common offset gathers. Tests on smooth velocity models with rugged topography verify the validity of the established equations, and the superiority of the proposed NFTI. The limitation of the proposed method is shown by an abruptly-varying velocity model example. Finally, the NFTI is applied to solve the static correction problem of the field seismic data acquired in a mountain area in the western China. The results confirm the effectivity of the proposed NFTI.

Simulation and analysis of the coherent-dispersion spectrometer for exoplanet detection

2021 ◽  
Vol 503 (2) ◽  
pp. 3032-3043
Author(s):  
Yinhua Wu ◽  
Shasha Chen ◽  
Pengchong Wang ◽  
Shun Zhou ◽  
Yutao Feng ◽  
...  
Keyword(s):  
Data Processing ◽  
Michelson Interferometer ◽  
Energy Utilization ◽  
Design Stage ◽  
Inversion Method ◽  
Fringe Visibility ◽  
Common Path ◽  
Data Processing Method ◽  
Detection Instrument ◽  
Performance Research

ABSTRACT The coherent-dispersion spectrometer (CODES) is a new exoplanet detection instrument using the radial velocity (RV) method. This attempts mainly to improve environmental sensitivity and energy utilization by using an asymmetric, common-path Sagnac interferometer instead of a traditional Michelson interferometer. In order to verify its feasibility and to choose the appropriate key parameters to obtain the optimal performance, research on data processing for the design stage of the CODES is performed by systematic simulation and analysis. First, the instrument modelling is carried out for further data analysis according to the principle of the CODES, and the reliability of the model is verified by experiments. Second, the influence of key parameters on fringe visibility is analysed systematically, which provides a certain reference for the choice of the key parameters. Third, the RV inversion method for the CODES is proposed and optimized according to the related analysis results so as to promote RV inversion precision. Finally, the recommended values for the key parameters of the CODES are given. The experimental results show that the data processing error of RV inversion is less than 0.6 m s–1 within the recommended range of key parameters. This indicates that the scheme of the CODES is reasonable and feasible, and that the proposed data processing method is effective and well matched with the instrument design.

A neural network-based inversion method of a feedback linearization controller applied to a hydraulic actuator

2021 ◽  
Vol 43 (5) ◽  
Author(s):  
Fábio Augusto Pires Borges ◽  
Eduardo André Perondi ◽  
Mauro André Barbosa Cunha ◽  
Mario Roland Sobczyk
Keyword(s):  
Neural Network ◽  
Feedback Linearization ◽  
Inversion Method ◽  
Hydraulic Actuator
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