Apoptosis participates to liver damage in HSV-induced fulminant hepatitis

J.-L. Prétet; L. Pelletier; B. Bernard; S. Coumes-Marquet; B. Kantelip; C. Mougin

doi:10.1023/a:1026156130656

Apoptosis participates to liver damage in HSV-induced fulminant hepatitis

APOPTOSIS ◽

10.1023/a:1026156130656 ◽

2003 ◽

Vol 8 (6) ◽

pp. 655-663 ◽

Cited By ~ 12

Author(s):

J.-L. Prétet ◽

L. Pelletier ◽

B. Bernard ◽

S. Coumes-Marquet ◽

B. Kantelip ◽

...

Keyword(s):

Liver Damage ◽

Fulminant Hepatitis

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Paracetamol overdose

Drug and Therapeutics Bulletin ◽

10.1136/dtb.14.2.5 ◽

1976 ◽

Vol 14 (2) ◽

pp. 5-7

Keyword(s):

At Risk ◽

Liver Damage ◽

Fulminant Hepatitis ◽

Therapeutic Dose ◽

Renal Damage ◽

Hepatic Necrosis ◽

Paracetamol Overdose ◽

Microsomal Enzymes ◽

Concomitant Increase ◽

Main Metabolite

Paracetamol is a main metabolite of phenacetin, and since its introduction it has become increasingly popular as a mild analgesic which is available without prescription. When taken in the recommended therapeutic dose of l g 6-hourly, paracetamol is relatively free from unwanted effects, and in particular, unlike phenacetin, there is little to associate it with renal damage. However, when taken as a single overdose, paracetamol can cause hepatic necrosis, the severity of which seems to be proportional to the dose of drug absorbed. All patients ingesting over 10 g (20 × 500 mg tablets) are at risk from liver damage, which may be potentiated by previous consumption of substances that induce microsomal enzymes, such as barbiturates or alcohol. Since the first reported cases of fulminant hepatitis due to paracetamol overdose in 1966 the number of cases of such self-poisoning has risen annually, with a concomitant increase in the number of deaths.

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Osteopontin Expression in Proliferated Bile Ductules: The Correlation with Liver Damage in Fulminant Hepatitis

Digestive Diseases and Sciences ◽

10.1007/s10620-005-1299-4 ◽

2005 ◽

Vol 50 (1) ◽

pp. 188-195 ◽

Cited By ~ 8

Author(s):

Takuma Tajiri ◽

Genshu Tate ◽

Toshiaki Kunimura ◽

Yutaka Endo ◽

Kazuaki Inoue ◽

...

Keyword(s):

Liver Damage ◽

Fulminant Hepatitis ◽

Osteopontin Expression

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Ultrastructural Changes in Patients With Heat Stroke

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100068047 ◽

1970 ◽

Vol 28 ◽

pp. 210-211

Author(s):

O. T. Minick ◽

M. C. Kew

Keyword(s):

Liver Damage ◽

Heat Stroke ◽

Free State ◽

Ultrastructural Changes ◽

Gold Mines

The effects of heat stroke on hepatic structure were studied in 32 Bantu patients who worked underground in the Transvaal and Orange Free State Gold Mines.Judging from biochemical and morphologic findings, liver damage is an invariable complication of heat stroke. In the milder cases (90 per cent) raised enzyme levels, bromsulphalein retention, and increased prothrombin times were the most common abnormalities.

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