Drug interactions and cytotoxic effects of paclitaxel in combination with carboplatin, epirubicin, gemcitabine or vinorelbine in breast cancer cell lines and tumor samples

2001 ◽  
Vol 67 (3) ◽  
pp. 223-233 ◽  
Author(s):  
Gottfried Konecny ◽  
Michael Untch ◽  
Dennis Slamon ◽  
Malgorzata Beryt ◽  
Steffen Kahlert ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Interactions ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Cytotoxic Effects

scholarly journals Apoptosis-mediated cytotoxic effects of parthenolide and the new synthetic analog MZ-6 on two breast cancer cell lines

2012 ◽  
Vol 40 (2) ◽  
pp. 1655-1663 ◽  
Author(s):  
Anna Wyrębska ◽  
Jacek Szymański ◽  
Katarzyna Gach ◽  
Justyna Piekielna ◽  
Jacek Koszuk ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Synthetic Analog ◽  
Cytotoxic Effects

scholarly journals Cytotoxicity and Apoptosis Inducing Effects of Some Lathyrane and Tigliane Diterpenes against Breast Cancer Cell Lines

2021 ◽  
Author(s):  
Melika Maleki ◽  
Zeinab Yazdiniapour ◽  
Mustafa Ghanadian ◽  
Behzad Zolfaghari ◽  
Faezeh Rabbani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Biological Effects ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Cytotoxic Effects ◽  
Apoptotic Effects ◽  
Mcf 7

Natural compounds and especially herbal medicine are of great interest due to their various biological effects and their potential to act as a drug for the treatment of various neoplasms especially breast cancer that we are facing with its increasing prevalence around the world. The aim of this study was to evaluate the cytotoxic and cell death mechanism of some diterpenoids (Lathyrane or Tigliane) extracted from the Euphorbia sogdiana Popov against two breast cancer cell lines, MCF-7 and 4T1. Determination the cytotoxic effects of four various diterpenoids was performed using MTT assay against MCF-7, 4T1, and HUVEC cell lines. The IC50 of each compound against cell lines was determined by drawing the dose-response graph using graph Pad prism software. Finally, the apoptotic effects of compound with the most cytotoxic effects was determined by flow cytometry assay for 24 hrs of incubation in IC50 concentration. Statistical analysis confirmed compound (3) with the most cytotoxicity against both cancer cell lines. The IC50 of compound (3) was determined as 10.1 ± 5, 28 ± 5, and 50 ± 3 µg/ml, for MCF-7, 4T1, and HUVEC cells, respectively. Furthermore, the cells treated with 5 and 10 μg/ml of compound (3) for 24 hrs, showed 49 and 57% of apoptosis. These surveyed compounds have the potential to be considered as useful anti-breast cancer agents due to the great cytotoxicity and apoptotic effects against related cancer cell lines and safety profile according to their rational selectivity index.

scholarly journals Synthesis and cytotoxic effects of (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one in MDA-MB231 and MCF-7 breast cancer cell lines

2017 ◽  
Vol 19 ◽  
pp. 145-150 ◽  
Author(s):  
Muhammad Nadeem Akhtar ◽  
Landa Zeenelabdin Ali Salim ◽  
Swee Keong Yeap ◽  
Nadiah Abu ◽  
Seema Zareen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Cytotoxic Effects ◽  
Mcf 7

scholarly journals Cytotoxic Effects of Diclofenac and Ibuprofen Zinc (II)-Nicotinamide Ternary Complexes in Breast Cancer Cell Lines

2021 ◽  
Vol 64 ◽  
Author(s):  
Emanuelle Fraga da Silva ◽  
Paulo Roberto dos Santos ◽  
Krist Helen Antunes Fernandes ◽  
Deise do Nascimento de Freitas ◽  
Rafael Fernandes Zanin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
Ternary Complexes ◽  
Breast Cancer Cell Lines ◽  
Cytotoxic Effects
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