Estrogen increases intracellular p26Bcl-2 to p21Bax ratios and inhibits taxol-induced apoptosis of human breast cancer MCF-7 cells

1997 ◽  
Vol 42 (1) ◽  
pp. 73-81 ◽  
Author(s):  
Yue Huang ◽  
Swapan Ray ◽  
John C. Reed ◽  
Ana Maria Ibrado ◽  
Caroline Tang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Induced Apoptosis ◽  
Mcf 7

scholarly journals Silibinin Enhances Ultraviolet B-Induced Apoptosis in MCF-7 Human Breast Cancer Cells

2011 ◽  
Vol 14 (1) ◽  
pp. 8 ◽  
Author(s):  
Eun-Mi Noh ◽  
Mi Suk Yi ◽  
Hyun Jo Youn ◽  
Byoung Kil Lee ◽  
Young-Rae Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Ultraviolet B ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Induced Apoptosis ◽  
Mcf 7

2-aryl benzimidazole conjugate induced apoptosis in human breast cancer MCF-7 cells through caspase independent pathway

APOPTOSIS ◽  
2016 ◽  
Vol 22 (1) ◽  
pp. 118-134 ◽  
Author(s):  
V. Lakshma Nayak ◽  
Narayana Nagesh ◽  
A. Ravikumar ◽  
Chandrakant Bagul ◽  
M. V. P. S. Vishnuvardhan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Induced Apoptosis ◽  
Mcf 7

scholarly journals Corn Silk (Zea mays L.) Induced Apoptosis in Human Breast Cancer (MCF-7) Cells via the ROS-Mediated Mitochondrial Pathway

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Mai M. Al-Oqail ◽  
Ebtesam S. Al-Sheddi ◽  
Nida N. Farshori ◽  
Shaza M. Al-Massarani ◽  
Eman A. Al-Turki ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Caspase 3 ◽  
Mitochondrial Pathway ◽  
Ros Production ◽  
Human Breast ◽  
Caspase 9 ◽  
Corn Silk ◽  
Induced Apoptosis ◽  
Mcf 7

Cancer has been recognized as one of the life-threating diseases. Breast cancer is a leading cause of mortality among women. In spite of current developments in the therapy and diagnosis of cancer, the survival rate is still less. Recently, plant-derived natural products gain attention as anticancer agents due to the nontoxic nature. Therefore, the aim of present study was to investigate the anticancer capacity of corn silk extract (CSE) on human breast cancer (MCF-7) and normal human mesenchymal (hMSC-TERT4) cells. Following 24 h treatment to corn silk extract, the cytotoxicity was assessed by MTT, NRU, and morphological assays. The oxidative stress markers (GSH and LPO), ROS production, MMP change, and expression of apoptotic marker genes (p53, Bax, Bcl-2, caspase-3, and caspase-9) were also studied in MCF-7 cells treated at 250 to 1000 μg/ml of CSE for 24 h. Our results showed that CSE decreased the cell viability and increased the apoptosis in a dose-dependent manner. The level of LPO and ROS production was found significantly higher; however, GSH and MMP level was observed lower in CSE-treated MCF-7 cells. The real-time PCR data showed a significant upregulation in p53, Bax, caspase-3, and caspase-9 and downregulation in the mRNA expression of Bcl-2 genes in MCF-7 cells exposed to CSE. Collectively, the data from this study stated that corn silk extract induced apoptosis via the ROS-mediated mitochondrial pathway in MCF-7 cells.

scholarly journals Protein tyrosine kinase, JNK, and ERK involvement in pseudolaric acid B-induced apoptosis of human breast cancer MCF-7 cells1

2008 ◽  
Vol 29 (9) ◽  
pp. 1069-1076 ◽  
Author(s):  
Jing-hua YU ◽  
Hong-jun WANG ◽  
Xiang-ru LI ◽  
Shin-ichi TASHIRO ◽  
Satoshi ONODERA ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tyrosine Kinase ◽  
Human Breast Cancer ◽  
Protein Tyrosine Kinase ◽  
Human Breast ◽  
Pseudolaric Acid B ◽  
Protein Tyrosine ◽  
Induced Apoptosis ◽  
Mcf 7

scholarly journals Silibinin-Induced Apoptosis and Downregulation of MicroRNA-21 and MicroRNA-155 in MCF-7 Human Breast Cancer Cells

2016 ◽  
Vol 19 (1) ◽  
pp. 45 ◽  
Author(s):  
Masoud Maleki Zadeh ◽  
Nasrin Motamed ◽  
Najmeh Ranji ◽  
Mohammad Majidi ◽  
Fahimeh Falahi
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Induced Apoptosis ◽  
Mcf 7
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