Glutathione Conjugation of Bay- and Fjord-Region Diol Epoxides of Polycyclic Aromatic Hydrocarbons by Glutathione Transferases M1-1 and P1-1

Kathrin Sundberg; Mikael Widersten; Albrecht Seidel; Bengt Mannervik; Bengt Jernström

doi:10.1021/tx970099w

Glutathione Conjugation of Bay- and Fjord-Region Diol Epoxides of Polycyclic Aromatic Hydrocarbons by Glutathione Transferases M1-1 and P1-1

Chemical Research in Toxicology ◽

10.1021/tx970099w ◽

1997 ◽

Vol 10 (11) ◽

pp. 1221-1227 ◽

Cited By ~ 68

Author(s):

Kathrin Sundberg ◽

Mikael Widersten ◽

Albrecht Seidel ◽

Bengt Mannervik ◽

Bengt Jernström

Keyword(s):

Polycyclic Aromatic Hydrocarbons ◽

Aromatic Hydrocarbons ◽

Glutathione Transferases ◽

Glutathione Conjugation ◽

Diol Epoxides ◽

Polycyclic Aromatic

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Role of arginine 216 in catalytic activity of murine Alpha class glutathione transferases mGSTAl-1 and mGSTA2-2 toward carcinogenic diol epoxides of polycyclic aromatic hydrocarbons

Carcinogenesis ◽

10.1093/carcin/22.8.1301 ◽

2001 ◽

Vol 22 (8) ◽

pp. 1301-1305 ◽

Cited By ~ 2

Author(s):

A. Pal

Keyword(s):

Polycyclic Aromatic Hydrocarbons ◽

Catalytic Activity ◽

Aromatic Hydrocarbons ◽

Glutathione Transferases ◽

Diol Epoxides ◽

Polycyclic Aromatic

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Molecular structures of the dihydrodiols and diol epoxides of carcinogenic polycyclic aromatic hydrocarbons. X-ray crystallographic and NMR analysis

Journal of the American Chemical Society ◽

10.1021/ja00509a004 ◽

1979 ◽

Vol 101 (15) ◽

pp. 4043-4051 ◽

Cited By ~ 31

Author(s):

D. E. Zacharias ◽

J. P. Glusker ◽

P. P. Fu ◽

R. G. Harvey

Keyword(s):

Polycyclic Aromatic Hydrocarbons ◽

Aromatic Hydrocarbons ◽

Molecular Structures ◽

Nmr Analysis ◽

X Ray ◽

Diol Epoxides ◽

Polycyclic Aromatic

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Tumorigenicity of Fjord Region Diol Epoxides of Polycyclic Aromatic Hydrocarbons

Polycyclic Aromatic Compounds ◽

10.1080/10406639608544688 ◽

1996 ◽

Vol 11 (1-4) ◽

pp. 365-371 ◽

Cited By ~ 5

Author(s):

Shantu Amin ◽

Dhimant Desai ◽

Karam El-Bayoumy ◽

Abraham Rivenson ◽

Stephen S. Hecht

Keyword(s):

Polycyclic Aromatic Hydrocarbons ◽

Aromatic Hydrocarbons ◽

Diol Epoxides ◽

Polycyclic Aromatic

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ChemInform Abstract: A Novel Regio- and Stereocontrolled Synthesis of Diol Epoxide and trans-Dihydrodiol Metabolites of Polycyclic Aromatic Hydrocarbons. An Application to the Synthesis of the Bay-Region syn- and anti-Diol Epoxides of the Carcinogen 1,4-D

ChemInform ◽

10.1002/chin.199102181 ◽

2010 ◽

Vol 22 (2) ◽

pp. no-no

Author(s):

M. KOREEDA ◽

K.-Y. JUNG ◽

M. HIROTA

Keyword(s):

Polycyclic Aromatic Hydrocarbons ◽

Aromatic Hydrocarbons ◽

Diol Epoxide ◽

Stereocontrolled Synthesis ◽

Diol Epoxides ◽

Polycyclic Aromatic

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Selective modification of nuclear proteins by polycyclic aromatic hydrocarbons and by benzo[a]pyrene diol epoxides

Carcinogenesis ◽

10.1093/carcin/3.7.821 ◽

1982 ◽

Vol 3 (7) ◽

pp. 821-824 ◽

Cited By ~ 6

Author(s):

Arend Kootstra ◽

Michael C. MacLeod ◽

Radhakrishnan Iyer ◽

James K. Selkirk ◽

Thomas J. Slaga

Keyword(s):

Polycyclic Aromatic Hydrocarbons ◽

Aromatic Hydrocarbons ◽

Nuclear Proteins ◽

Diol Epoxides ◽

Polycyclic Aromatic

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Detoxication of carcinogenic fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferase P1-1 variants and glutathione

FEBS Letters ◽

10.1016/s0014-5793(98)01291-5 ◽

1998 ◽

Vol 438 (3) ◽

pp. 206-210 ◽

Cited By ~ 32

Author(s):

Kathrin Sundberg ◽

Albrecht Seidel ◽

Bengt Mannervik ◽

Bengt Jernström

Keyword(s):

Polycyclic Aromatic Hydrocarbons ◽

Aromatic Hydrocarbons ◽

Glutathione Transferase ◽

Diol Epoxides ◽

Polycyclic Aromatic

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Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by tannic acid, hydroxylated anthraquinones and hydroxylated cinnamic acid derivatives

Carcinogenesis ◽

10.1093/carcin/6.2.237 ◽

1985 ◽

Vol 6 (2) ◽

pp. 237-242 ◽

Cited By ~ 68

Author(s):

Mou-Tuan Huang ◽

Richard L. Chang ◽

Alexander W. Wood ◽

Harold L. Newmark ◽

Jane M. Sayer ◽

...

Keyword(s):

Polycyclic Aromatic Hydrocarbons ◽

Tannic Acid ◽

Cinnamic Acid ◽

Aromatic Hydrocarbons ◽

Cinnamic Acid Derivatives ◽

Diol Epoxides ◽

Polycyclic Aromatic

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Stereoelectronic factors in the solvolysis of bay region diol epoxides of polycyclic aromatic hydrocarbons

Journal of the American Chemical Society ◽

10.1021/ja00484a058 ◽

1978 ◽

Vol 100 (16) ◽

pp. 5218-5221 ◽

Cited By ~ 52

Author(s):

Dale L. Whalen ◽

Angela M. Ross ◽

Haruhiko Yagi ◽

Jean M. Karle ◽

Donald M. Jerina

Keyword(s):

Polycyclic Aromatic Hydrocarbons ◽

Aromatic Hydrocarbons ◽

Diol Epoxides ◽

Polycyclic Aromatic

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CARCINOGENESIS: Glutathione S-transferase A1–1-catalysed conjugation of bay and fjord region diol epoxides of polycyclic aromatic hydrocarbons with glutathione

Carcinogenesis ◽

10.1093/carcin/17.7.1491 ◽

1996 ◽

Vol 17 (7) ◽

pp. 1491-1498 ◽

Cited By ~ 57

Author(s):

Bengt Jernström ◽

Mario Funk ◽

Heinrich Frank ◽

Bengt Mannervik ◽

Albrecht Seidel

Keyword(s):

Polycyclic Aromatic Hydrocarbons ◽

Aromatic Hydrocarbons ◽

Glutathione S Transferase ◽

Diol Epoxides ◽

Polycyclic Aromatic

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Glutathione Transferase Catalyzed Conjugation of Diol Epoxides Derived from Polycyclic Aromatic Hydrocarbons with Glutathione

Polycyclic Aromatic Compounds ◽

10.1080/10406639308009611 ◽

1993 ◽

Vol 3 (4) ◽

pp. 213-219 ◽

Cited By ~ 1

Author(s):

B. Jernström ◽

M. Funk ◽

T. Steinbrecher ◽

A. Seidel

Keyword(s):

Polycyclic Aromatic Hydrocarbons ◽

Aromatic Hydrocarbons ◽

Glutathione Transferase ◽

Diol Epoxides ◽

Polycyclic Aromatic

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