Delphinidin Modulates the DNA-Damaging Properties of Topoisomerase II Poisons

2009 ◽  
Vol 22 (3) ◽  
pp. 554-564 ◽  
Author(s):  
Melanie Esselen ◽  
Jessica Fritz ◽  
Melanie Hutter ◽  
Doris Marko
Keyword(s):  
Topoisomerase Ii ◽  
Topoisomerase Ii Poisons

A protein-mediated mechanism for the DNA sequence-specific action of topoisomerase II poisons

1997 ◽  
Vol 18 (4) ◽  
pp. 323-329 ◽  
Author(s):  
Giovanni Capranico ◽  
Monica Binaschi ◽  
M.Evelina Borgnetto ◽  
Franco Zunino ◽  
Manlio Palumbo
Keyword(s):  
Dna Sequence ◽  
Topoisomerase Ii ◽  
Topoisomerase Ii Poisons

scholarly journals Topoisomerases as anticancer targets

2018 ◽  
Vol 475 (2) ◽  
pp. 373-398 ◽  
Author(s):  
Justine L. Delgado ◽  
Chao-Ming Hsieh ◽  
Nei-Li Chan ◽  
Hiroshi Hiasa
Keyword(s):  
Anticancer Drugs ◽  
Anticancer Agents ◽  
Topoisomerase Ii ◽  
Therapeutic Targets ◽  
Strand Break ◽  
Cancer Type ◽  
Topoisomerase Inhibitors ◽  
Topoisomerase Ii Poisons ◽  
Topoisomerase Poisons ◽  
Replication Fork Arrest

Many cancer type-specific anticancer agents have been developed and significant advances have been made toward precision medicine in cancer treatment. However, traditional or nonspecific anticancer drugs are still important for the treatment of many cancer patients whose cancers either do not respond to or have developed resistance to cancer-specific anticancer agents. DNA topoisomerases, especially type IIA topoisomerases, are proved therapeutic targets of anticancer and antibacterial drugs. Clinically successful topoisomerase-targeting anticancer drugs act through topoisomerase poisoning, which leads to replication fork arrest and double-strand break formation. Unfortunately, this unique mode of action is associated with the development of secondary cancers and cardiotoxicity. Structures of topoisomerase–drug–DNA ternary complexes have revealed the exact binding sites and mechanisms of topoisomerase poisons. Recent advances in the field have suggested a possibility of designing isoform-specific human topoisomerase II poisons, which may be developed as safer anticancer drugs. It may also be possible to design catalytic inhibitors of topoisomerases by targeting certain inactive conformations of these enzymes. Furthermore, identification of various new bacterial topoisomerase inhibitors and regulatory proteins may inspire the discovery of novel human topoisomerase inhibitors. Thus, topoisomerases remain as important therapeutic targets of anticancer agents.

scholarly journals Glucosylated Isoflavones as DNA Topoisomerase II Poisons

2000 ◽  
Vol 15 (5) ◽  
pp. 455-460 ◽  
Author(s):  
C. Martín-Cordero ◽  
M. López-Lazaro ◽  
J. Piñero ◽  
T. Ortiz ◽  
F. Cortés ◽  
...  
Keyword(s):  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Topoisomerase Ii Poisons

scholarly journals Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons

PLoS Genetics ◽  
2017 ◽  
Vol 13 (7) ◽  
pp. e1006891 ◽  
Author(s):  
Stefan Zdraljevic ◽  
Christine Strand ◽  
Hannah S. Seidel ◽  
Daniel E. Cook ◽  
John G. Doench ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Substitution ◽  
Natural Variation ◽  
Topoisomerase Ii ◽  
Physiological Responses ◽  
Single Amino Acid Substitution ◽  
Single Amino Acid ◽  
Topoisomerase Ii Poisons

Tumor Cell Resistance to Topoisomerase II Poisons

1998 ◽  
Vol 56 (3) ◽  
pp. 345-349 ◽  
Author(s):  
Dale R. Grabowski ◽  
George R. Dubyak ◽  
Lisa Rybicki ◽  
Hiroyoshi Hidaka ◽  
Ram Ganapathi
Keyword(s):  
Tumor Cell ◽  
Topoisomerase Ii ◽  
Cell Resistance ◽  
Topoisomerase Ii Poisons ◽  
Tumor Cell Resistance

A protein-mediated mechanism for the DNA sequence-specific action of topoisomerase II poisons

1997 ◽  
Vol 18 (9) ◽  
pp. 323-329 ◽  
Author(s):  
Giovanni Capranico ◽  
Monica Binaschi ◽  
M.Evelina Borgnetto ◽  
Franco Zunino ◽  
Manlio Palumbo
Keyword(s):  
Dna Sequence ◽  
Topoisomerase Ii ◽  
Topoisomerase Ii Poisons

Genotoxicity of dietary, environmental and therapeutic topoisomerase II poisons is uniformly correlated to prolongation of enzyme DNA residence

2011 ◽  
Vol 55 (S1) ◽  
pp. S127-S142 ◽  
Author(s):  
Faiza M. Kalfalah ◽  
Christian Mielke ◽  
Morten O. Christensen ◽  
Simone Baechler ◽  
Doris Marko ◽  
...  
Keyword(s):  
Topoisomerase Ii ◽  
Topoisomerase Ii Poisons
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